SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 6 ASN A 178
ASP A 212
ILE A 252
ILE A 219
 None
 0.94A 1n49D-4bofA:
undetectable		 1n49D-4bofA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 297
LEU A 298
PHE A 267
SER A 354
LEU A 276
 None
 1.15A 1rx3A-4bofA:
undetectable		 1rx3A-4bofA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 11 LEU A  71
ILE A 195
PHE A 168
ASP A 166
GLY A 221
 PGE  A 422 (-3.7A)
None
PGE  A 422 (-3.9A)
None
None
 1.25A 1zz1A-4bofA:
undetectable		 1zz1A-4bofA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 5 LEU A  61
GLY A  14
PRO A 405
VAL A  19
 None
 0.89A 2aojA-4bofA:
undetectable		 2aojA-4bofA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 5 SER A 237
GLY A 235
HIS A 291
ASP A 277
 None
 1.09A 2oxtB-4bofA:
undetectable		 2oxtB-4bofA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 9 LEU A  61
ILE A  13
PRO A 405
VAL A  19
ILE A  66
 None
 1.11A 2r5qA-4bofA:
undetectable		 2r5qA-4bofA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 9 LEU A  61
ILE A  13
PRO A 405
VAL A  19
ILE A  66
 None
 1.11A 2r5qC-4bofA:
undetectable		 2r5qC-4bofA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 9 LEU A  61
GLY A  14
ILE A  13
PRO A 405
ILE A  66
 None
 0.97A 3el0B-4bofA:
undetectable		 3el0B-4bofA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 10 LEU A  61
GLY A  14
PRO A 405
VAL A  19
ILE A  66
 None
 0.98A 3em3B-4bofA:
undetectable		 3em3B-4bofA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		6 / 12 LEU A  61
GLY A  14
ILE A  13
PRO A 405
VAL A  19
ILE A  66
 None
 1.28A 3ndtB-4bofA:
undetectable		 3ndtB-4bofA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 10 LEU A  61
GLY A  14
PRO A 405
VAL A  19
ILE A  66
 None
 1.00A 3oxwD-4bofA:
undetectable		 3oxwD-4bofA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 11 LEU A  61
GLY A  14
PRO A 405
VAL A  19
ILE A  66
 None
 0.99A 3oxxD-4bofA:
undetectable		 3oxxD-4bofA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 5 THR A 170
ILE A   7
PHE A 196
LEU A  20
 None
 1.45A 3tf1A-4bofA:
undetectable		 3tf1A-4bofA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A  36
GLY A 395
GLY A 398
ASP A  42
PRO A 159
 None
 1.05A 4blvA-4bofA:
undetectable		 4blvA-4bofA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 7 TYR A 202
THR A 170
LEU A  69
VAL A   9
 None
 0.74A 4cp4A-4bofA:
undetectable		 4cp4A-4bofA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 GLN A 349
GLY A 398
ASN A 370
GLU A  53
TYR A 162
 None
 1.17A 4pclA-4bofA:
undetectable		 4pclA-4bofA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 6 HIS A 388
GLY A 389
ARG A 369
ASN A 368
 SO4  A 420 (-4.6A)
SO4  A 420 (-3.3A)
SO4  A 420 (-3.6A)
SO4  A 420 (-4.8A)
 1.33A 4zbqA-4bofA:
undetectable		 4zbqA-4bofA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		3 / 3 ARG A 299
LYS A 316
GLU A 314
 None
 0.78A 5d0yA-4bofA:
undetectable		 5d0yA-4bofA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 ASP A 241
SER A 244
SER A 176
GLU A 224
GLU A 183
 None
 1.46A 5iqeC-4bofA:
undetectable		 5iqeC-4bofA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_2
(PROTEASE PR5-SQV)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 9 LEU A  61
GLY A  14
PRO A 405
VAL A  19
ILE A  66
 None
 1.05A 5kr2D-4bofA:
undetectable		 5kr2D-4bofA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 177
ASP A 212
LEU A 232
VAL A 226
GLY A 205
 None
 1.09A 5uxdB-4bofA:
undetectable		 5uxdB-4bofA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 8 ILE A 290
LEU A 263
ALA A 233
LEU A 227
 None
 0.80A 5y7pC-4bofA:
undetectable		 5y7pC-4bofA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 196
LEU A 232
VAL A 226
PHE A 259
THR A 173
 None
 1.34A 6brdA-4bofA:
undetectable		 6brdA-4bofA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4bof ARGININE DEIMINASE
(Streptococcus
pyogenes) 		4 / 6 PRO A 200
ILE A 195
GLY A 203
TYR A 202
 None
 1.01A 6gqiA-4bofA:
undetectable		 6gqiA-4bofA:
23.99