SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 GLU A 231
HIS A 234
ASP A 239
 None
 0.84A 1i9gA-4bokA:
undetectable		 1i9gA-4bokA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 10 GLY A 250
VAL A 253
GLY A 254
THR A 247
ASN A 305
 None
 1.27A 1v3qE-4bokA:
undetectable		 1v3qE-4bokA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 LEU A  81
ASN A  49
PHE A  48
VAL A 105
GLN A 101
 None
 1.17A 2xpwA-4bokA:
undetectable		 2xpwA-4bokA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 VAL A 369
ASN A  49
TRP A  53
 None
 0.99A 2y00B-4bokA:
undetectable		 2y00B-4bokA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 ARG A 304
MET A 131
ARG A 135
 None
 1.40A 3uvvA-4bokA:
undetectable		 3uvvA-4bokA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 THR A 179
ASN A 181
GLU A 231
 None
 0.80A 3v4tA-4bokA:
undetectable
3v4tC-4bokA:
undetectable		 3v4tA-4bokA:
22.82
3v4tC-4bokA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 LEU A  81
ASN A  49
PHE A  48
VAL A 105
GLN A 101
 None
 1.17A 4b3aA-4bokA:
undetectable		 4b3aA-4bokA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 8 TRP A 128
ASN A 305
GLY A 250
SER A 251
 None
 0.78A 4f93B-4bokA:
undetectable		 4f93B-4bokA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 ARG A 150
LEU A 146
GLU A 147
 None
 0.75A 4l3gF-4bokA:
undetectable		 4l3gF-4bokA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 5 TYR A 243
ASP A  71
GLU A  77
VAL A 105
 None
 1.28A 4nkvA-4bokA:
undetectable		 4nkvA-4bokA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 5 TYR A 243
ASP A  71
GLU A  77
VAL A 105
 None
 1.29A 4nkvB-4bokA:
undetectable		 4nkvB-4bokA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 7 GLY A 374
GLN A 190
TYR A 194
ASP A 327
 None
 1.15A 5vlmE-4bokA:
1.4		 5vlmE-4bokA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		3 / 3 TYR A 243
ASP A 124
ASP A 294
 None
 0.84A 5x6yA-4bokA:
undetectable		 5x6yA-4bokA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 10 VAL A 253
GLY A 254
ALA A 268
LEU A 265
ASN A 261
 None
 1.19A 5x6yB-4bokA:
undetectable		 5x6yB-4bokA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		5 / 12 MET A 127
ALA A 207
HIS A 308
LEU A 195
ALA A 134
 None
 0.99A 6djzC-4bokA:
undetectable		 6djzC-4bokA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bok ALPHA-1,6-MANNANASE
(Bacillus
circulans) 		4 / 8 ASP A  71
GLU A 361
ASP A  63
GLU A  67
 None
 1.22A 6mn4D-4bokA:
undetectable		 6mn4D-4bokA:
19.78