SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		3 / 3 ASN A 108
ALA A 111
ASN A 621
 None
 0.79A 1n4fA-4bomA:
undetectable		 1n4fA-4bomA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		5 / 12 ALA A 390
ASP A 373
SER A 388
ARG A 377
TYR A 452
 None
 1.35A 1xvaB-4bomA:
undetectable		 1xvaB-4bomA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		3 / 3 ARG A 474
SER A 473
TYR A 442
 None
 1.03A 2q2hA-4bomA:
undetectable
2q2hB-4bomA:
undetectable		 2q2hA-4bomA:
12.62
2q2hB-4bomA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 7 TYR A 114
CYH A 573
CYH A 116
GLU A 622
 None
 1.16A 2xytD-4bomA:
undetectable		 2xytD-4bomA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 7 TYR A 114
CYH A 573
CYH A 116
GLU A 622
 None
 1.34A 2xytG-4bomA:
0.0		 2xytG-4bomA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 7 TYR A 114
CYH A 573
CYH A 116
GLU A 622
 None
 1.30A 2xytH-4bomA:
0.0		 2xytH-4bomA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 4 VAL A 273
ARG A 328
ILE A 198
THR A 249
 None
 1.30A 3cl9A-4bomA:
undetectable		 3cl9A-4bomA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 7 GLU A 196
ARG A 208
THR A 210
ALA A 211
 None
 1.07A 3mbgA-4bomA:
undetectable
3mbgB-4bomA:
undetectable		 3mbgA-4bomA:
12.55
3mbgB-4bomA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 6 LEU A 463
TYR A 464
ARG A 466
LEU A 456
 None
 1.11A 3rd0A-4bomA:
undetectable		 3rd0A-4bomA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		3 / 3 TYR A 213
PHE A 186
ARG A 215
 None
 0.99A 4g19D-4bomA:
undetectable		 4g19D-4bomA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		5 / 12 PHE A 395
ILE A 391
ALA A 504
THR A 497
LEU A 443
 None
 1.35A 4qynA-4bomA:
undetectable		 4qynA-4bomA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 5 LEU A 330
ASP A 329
TYR A 164
THR A 162
 None
 1.20A 4wozF-4bomA:
undetectable
4wozH-4bomA:
undetectable		 4wozF-4bomA:
17.86
4wozH-4bomA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 6 ARG A 360
GLY A 410
ASP A 411
ASP A 408
 None
 1.27A 5hp1A-4bomA:
2.1		 5hp1A-4bomA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		3 / 3 GLY A 594
CYH A 633
CYH A 596
 None
 0.74A 5inzB-4bomA:
undetectable		 5inzB-4bomA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 5 PHE A 386
ILE A 450
MET A 375
ARG A 377
 None
 1.48A 5jm4A-4bomA:
undetectable		 5jm4A-4bomA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 8 ILE A 501
ARG A 505
ALA A 504
PHE A 395
 None
 1.04A 5m0oC-4bomA:
undetectable		 5m0oC-4bomA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 4bom ENVELOPE
GLYCOPROTEIN B
(Human
alphaherpesvirus
1) 		4 / 4 GLN A 616
VAL A 613
ARG A 562
ARG A 624
 None
 1.25A 6brdA-4bomA:
undetectable		 6brdA-4bomA:
8.56