SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		3 / 3 TRP A 326
ALA A 322
VAL A 282
 None
 0.93A 1bdwA-4bp8A:
undetectable
1bdwB-4bp8A:
undetectable		 1bdwA-4bp8A:
1.86
1bdwB-4bp8A:
1.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 5 HIS A 545
GLU A 449
ALA A 508
HIS A 511
 None
 1.18A 1errA-4bp8A:
undetectable
1errB-4bp8A:
undetectable		 1errA-4bp8A:
15.87
1errB-4bp8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 8 PHE A 178
VAL A 194
ASP A 185
VAL A 187
 None
 0.98A 1iwiA-4bp8A:
undetectable		 1iwiA-4bp8A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 7 VAL A 632
HIS A  57
GLU A  61
LEU A  44
 None
 1.06A 1j96B-4bp8A:
undetectable		 1j96B-4bp8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		3 / 3 THR A 124
GLU A 131
ASP A 136
 None
 0.82A 1nt2A-4bp8A:
undetectable		 1nt2A-4bp8A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 7 PHE A 178
VAL A 194
VAL A 187
ASP A 185
 None
 0.95A 1p7rA-4bp8A:
undetectable		 1p7rA-4bp8A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 8 THR A 363
VAL A 350
VAL A 344
ALA A 401
 None
 0.97A 2ij7C-4bp8A:
undetectable		 2ij7C-4bp8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 ARG A 213
ILE A 255
LEU A 279
GLU A 264
 None
 1.08A 2ya7A-4bp8A:
9.3		 2ya7A-4bp8A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 ARG A 213
ILE A 255
LEU A 279
GLU A 264
 None
 1.07A 2ya7D-4bp8A:
9.1		 2ya7D-4bp8A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 GLY A 515
ILE A 487
GLU A 517
ILE A 489
 None
 0.79A 3a7eA-4bp8A:
undetectable		 3a7eA-4bp8A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PHE A 580
LEU A 579
GLU A 544
ALA A 510
PHE A 539
 None
 1.34A 3apwB-4bp8A:
undetectable		 3apwB-4bp8A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 8 SER A 625
ARG A 533
ALA A 571
ILE A 540
 None
 0.91A 3bpxA-4bp8A:
undetectable
3bpxB-4bp8A:
undetectable		 3bpxA-4bp8A:
11.08
3bpxB-4bp8A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		3 / 3 GLU A 384
VAL A 445
CYH A 446
 None
 0.89A 3fbxA-4bp8A:
undetectable		 3fbxA-4bp8A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 LYS A 532
VAL A 569
VAL A 592
ARG A 562
 None
 1.10A 3ms9A-4bp8A:
undetectable		 3ms9A-4bp8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 LYS A 532
VAL A 569
VAL A 592
ARG A 562
 None
 1.11A 3mssA-4bp8A:
undetectable		 3mssA-4bp8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 LYS A 532
VAL A 569
VAL A 592
ARG A 562
 None
 1.15A 3mssC-4bp8A:
undetectable		 3mssC-4bp8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 8 SER A 193
ILE A 206
ILE A 255
LEU A 253
 None
 0.94A 4dtaB-4bp8A:
undetectable		 4dtaB-4bp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PRO A 638
LEU A 640
VAL A 590
VAL A 569
PRO A 656
 None
 1.45A 4id5A-4bp8A:
0.8		 4id5A-4bp8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PRO A 638
LEU A 640
VAL A 590
VAL A 569
PRO A 656
 None
 1.46A 4ig3A-4bp8A:
0.6		 4ig3A-4bp8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PRO A 638
LEU A 640
VAL A 590
VAL A 569
PRO A 656
 None
 1.39A 4kfbA-4bp8A:
0.8		 4kfbA-4bp8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 LEU A  44
ASP A 591
ILE A   8
PRO A 628
 None
 1.08A 4xi3C-4bp8A:
undetectable		 4xi3C-4bp8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 SER A 462
ASP A 538
ARG A 513
GLY A 515
 None
 0.93A 5cdqA-4bp8A:
undetectable
5cdqC-4bp8A:
undetectable
5cdqD-4bp8A:
3.3		 5cdqA-4bp8A:
20.79
5cdqC-4bp8A:
20.79
5cdqD-4bp8A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PRO A 638
LEU A 640
VAL A 590
VAL A 569
LEU A 663
 None
 1.43A 5cymA-4bp8A:
undetectable		 5cymA-4bp8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 10 ALA A 510
LEU A 479
MET A 478
GLY A 561
LEU A 568
 None
 1.34A 5dx3A-4bp8A:
undetectable		 5dx3A-4bp8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 10 ALA A 510
LEU A 479
MET A 478
GLY A 561
LEU A 568
 None
 1.29A 5dxbA-4bp8A:
undetectable		 5dxbA-4bp8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 11 ALA A 510
LEU A 479
MET A 478
GLY A 561
LEU A 568
 None
 1.25A 5dxgB-4bp8A:
undetectable		 5dxgB-4bp8A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 5 TYR A 507
LEU A 704
PRO A 499
LEU A 584
 None
 1.39A 5eshA-4bp8A:
undetectable		 5eshA-4bp8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 4 GLN A 699
GLN A 643
PRO A 588
ALA A 644
 None
 1.41A 5odcA-4bp8A:
4.1
5odcG-4bp8A:
undetectable		 5odcA-4bp8A:
22.08
5odcG-4bp8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 5 PRO A 588
ALA A 644
GLN A 699
GLN A 643
 None
 1.40A 5odcA-4bp8A:
4.2
5odcG-4bp8A:
undetectable		 5odcA-4bp8A:
22.08
5odcG-4bp8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 9 ALA A 510
LEU A 479
MET A 478
GLY A 561
LEU A 568
 None
 1.25A 5wgqA-4bp8A:
undetectable		 5wgqA-4bp8A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 GLU A 517
VAL A 572
PHE A 539
ILE A 540
PHE A 536
 None
 1.35A 6becA-4bp8A:
undetectable
6becB-4bp8A:
undetectable
6becC-4bp8A:
undetectable		 6becA-4bp8A:
21.80
6becB-4bp8A:
21.80
6becC-4bp8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 6 TYR A 291
TRP A 326
THR A 324
THR A 318
 None
 1.41A 6cnkA-4bp8A:
2.0
6cnkB-4bp8A:
undetectable		 6cnkA-4bp8A:
8.53
6cnkB-4bp8A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 7 GLN A 699
GLY A 570
GLY A 566
VAL A 590
 None
 0.86A 6ekzA-4bp8A:
undetectable		 6ekzA-4bp8A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		5 / 12 PRO A 638
LEU A 640
VAL A 590
VAL A 569
LEU A 663
 None
 1.45A 6eliA-4bp8A:
undetectable		 6eliA-4bp8A:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4bp8 OLIGOPEPTIDASE B
(Trypanosoma
brucei) 		4 / 8 ASN A 138
HIS A 116
VAL A 149
TYR A 164
 None
 1.21A 6huoC-4bp8A:
undetectable
6huoD-4bp8A:
undetectable		 6huoC-4bp8A:
6.85
6huoD-4bp8A:
7.02