SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A1721
GLY A1732
ASP A1734
 None
 0.58A 1kf6A-4bpcA:
undetectable
1kf6B-4bpcA:
undetectable		 1kf6A-4bpcA:
21.54
1kf6B-4bpcA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 8 SER A1411
LEU A1435
ASP A1445
GLU A1481
 None
 1.08A 1mxgA-4bpcA:
undetectable		 1mxgA-4bpcA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
 None
 1.12A 1nbhA-4bpcA:
undetectable		 1nbhA-4bpcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
 None
 1.11A 1nbhC-4bpcA:
undetectable		 1nbhC-4bpcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
 None
 1.12A 1nbhD-4bpcA:
undetectable		 1nbhD-4bpcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
 None
 1.13A 1nbiB-4bpcA:
undetectable		 1nbiB-4bpcA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 PHE A1909
TYR A1929
ARG A1686
VAL A1923
 None
 1.27A 1wu8A-4bpcA:
undetectable
1wu8C-4bpcA:
undetectable		 1wu8A-4bpcA:
17.88
1wu8C-4bpcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 7 TYR A1422
VAL A1593
GLY A1594
THR A1634
 None
None
CSO  A1589 ( 3.7A)
None
 0.88A 2a1mA-4bpcA:
undetectable		 2a1mA-4bpcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 ILE A1462
THR A1486
ALA A1485
ASN A1578
TYR A1451
 None
 1.16A 2gl0A-4bpcA:
undetectable
2gl0C-4bpcA:
undetectable		 2gl0A-4bpcA:
14.41
2gl0C-4bpcA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 LEU A1897
ILE A1908
VAL A1906
ALA A1936
 None
 0.96A 2j5mA-4bpcA:
undetectable		 2j5mA-4bpcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 LEU A1435
ILE A1462
THR A1464
ASP A1474
LEU A1536
 None
 1.13A 2jn3A-4bpcA:
undetectable		 2jn3A-4bpcA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ASN A1420
ASN A1448
ARG A1628
 None
 0.73A 2rlcA-4bpcA:
undetectable		 2rlcA-4bpcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ASN A1709
ASN A1737
ARG A1919
 None
 0.69A 2rlcA-4bpcA:
undetectable		 2rlcA-4bpcA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 GLY A1885
GLY A1883
THR A1887
LEU A1779
VAL A1889
 None
 1.15A 2wa2A-4bpcA:
undetectable		 2wa2A-4bpcA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A1432
ASP A1474
ASN A1416
 None
 0.88A 2zzmA-4bpcA:
undetectable		 2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A1721
ASP A1763
ASN A1705
 None
 0.80A 2zzmA-4bpcA:
undetectable		 2zzmA-4bpcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 PHE A1859
TYR A1818
VAL A1863
ILE A1775
PHE A1823
 None
 1.40A 3apwA-4bpcA:
undetectable		 3apwA-4bpcA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 4 PRO A1402
THR A1622
GLY A1597
THR A1596
 None
None
None
CSO  A1589 ( 4.0A)
 1.13A 3ib1A-4bpcA:
undetectable		 3ib1A-4bpcA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 11 LYS A1789
GLY A1885
THR A1780
GLU A1928
ALA A1921
 None
 1.31A 3id5B-4bpcA:
undetectable		 3id5B-4bpcA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 11 LYS A1789
GLY A1885
THR A1780
GLU A1928
ALA A1921
 None
 1.32A 3id5F-4bpcA:
undetectable		 3id5F-4bpcA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 10 LEU A1645
VAL A1601
ILE A1600
TYR A1461
ILE A1585
 None
 1.29A 3kz7A-4bpcA:
undetectable		 3kz7A-4bpcA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 ALA A1427
ILE A1426
VAL A1593
ASN A1629
 None
 1.19A 3nneG-4bpcA:
undetectable		 3nneG-4bpcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 11 LEU A1645
MET A1631
VAL A1632
GLY A1597
ALA A1598
 None
 1.25A 3pghB-4bpcA:
undetectable		 3pghB-4bpcA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 PRO A1756
GLY A1755
ASN A1705
MET A1715
PHE A1697
 None
 1.28A 3r24A-4bpcA:
undetectable		 3r24A-4bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A1421
TYR A1428
ASN A1412
 None
 0.82A 4ffwB-4bpcA:
undetectable		 4ffwB-4bpcA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 VAL A1587
ALA A1463
PHE A1570
PHE A1599
GLY A1597
 None
 1.24A 4mm6A-4bpcA:
undetectable		 4mm6A-4bpcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		5 / 12 VAL A1878
ALA A1752
PHE A1859
PHE A1890
GLY A1888
 None
 1.29A 4mm6A-4bpcA:
undetectable		 4mm6A-4bpcA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 6 PHE A1475
TRP A1476
ARG A1477
GLY A1514
 None
 1.10A 5o4yF-4bpcA:
undetectable		 5o4yF-4bpcA:
2.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 8 GLN A1934
GLY A1853
TRP A1844
ASP A1843
 None
 1.00A 5vlmD-4bpcA:
undetectable		 5vlmD-4bpcA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		3 / 3 ARG A1787
LYS A1789
ARG A1919
 None
 0.85A 6c06D-4bpcA:
undetectable		 6c06D-4bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens) 		4 / 5 TYR A1446
GLY A1443
HIS A1410
ASP A1429
 None
 1.26A 6gh9A-4bpcA:
undetectable		 6gh9A-4bpcA:
9.79