SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 LEU A 325
LEU A 317
ALA A 314
LEU A 296
ILE A 339
 None
 1.28A 1g5yB-4bpsA:
undetectable		 1g5yB-4bpsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 9 PHE A 123
TYR A 119
THR A 137
VAL A 225
ILE A 171
 None
 1.17A 1gebA-4bpsA:
undetectable		 1gebA-4bpsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4bps FKBO
(Streptomyces
hygroscopicus) 		3 / 3 PHE A 241
TRP A  76
GLU A  74
 None
 1.18A 1mogA-4bpsA:
1.6		 1mogA-4bpsA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ASN A 139
ALA A 179
MET A 176
LEU A 166
THR A 115
 3EB  A1345 ( 4.7A)
3EB  A1345 (-2.9A)
None
None
None
 1.30A 1ya3B-4bpsA:
undetectable		 1ya3B-4bpsA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ALA A 196
LEU A 133
ALA A 135
THR A 230
GLN A 285
 None
 1.14A 2jjpA-4bpsA:
undetectable		 2jjpA-4bpsA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ASN A 139
ALA A 179
MET A 176
LEU A 166
THR A 115
 3EB  A1345 ( 4.7A)
3EB  A1345 (-2.9A)
None
None
None
 1.35A 2oaxB-4bpsA:
undetectable		 2oaxB-4bpsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ASN A 139
ALA A 179
MET A 176
LEU A 166
THR A 115
 3EB  A1345 ( 4.7A)
3EB  A1345 (-2.9A)
None
None
None
 1.31A 2oaxC-4bpsA:
undetectable		 2oaxC-4bpsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ASN A 139
ALA A 179
MET A 176
LEU A 166
THR A 115
 3EB  A1345 ( 4.7A)
3EB  A1345 (-2.9A)
None
None
None
 1.32A 2oaxF-4bpsA:
undetectable		 2oaxF-4bpsA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 4bps FKBO
(Streptomyces
hygroscopicus) 		3 / 3 SER A 128
ARG A 127
GLN A 124
 None
 0.87A 2xnrA-4bpsA:
undetectable		 2xnrA-4bpsA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 PHE A 158
ALA A 112
THR A 105
ASN A 148
GLY A 109
 None
 1.47A 3aobC-4bpsA:
undetectable		 3aobC-4bpsA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 THR A 137
PHE A 158
ALA A 165
VAL A 141
TYR A 140
 None
 1.02A 3dl9A-4bpsA:
undetectable		 3dl9A-4bpsA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 VAL A  75
VAL A  54
GLY A  56
ALA A  57
LEU A  39
 None
 0.96A 3hs6A-4bpsA:
undetectable		 3hs6A-4bpsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ILE A 330
ALA A 244
ARG A 310
LEU A 306
THR A 180
 None
3EB  A1345 (-3.6A)
None
None
None
 1.18A 3ix9B-4bpsA:
undetectable		 3ix9B-4bpsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 11 PHE A 241
ALA A 196
ALA A 135
ALA A 195
LEU A  39
 None
 1.15A 4jbtB-4bpsA:
undetectable		 4jbtB-4bpsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bps FKBO
(Streptomyces
hygroscopicus) 		4 / 8 PHE A 123
THR A 137
VAL A 225
ILE A 171
 None
 0.94A 4l4cB-4bpsA:
undetectable		 4l4cB-4bpsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4bps FKBO
(Streptomyces
hygroscopicus) 		4 / 5 ALA A 112
THR A 115
VAL A 141
ILE A 189
 None
 0.96A 4xe3A-4bpsA:
undetectable		 4xe3A-4bpsA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4bps FKBO
(Streptomyces
hygroscopicus) 		4 / 6 GLU A  74
THR A 137
TYR A 299
PHE A  24
 None
 1.19A 5lrbA-4bpsA:
undetectable		 5lrbA-4bpsA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4bps FKBO
(Streptomyces
hygroscopicus) 		3 / 3 THR A 180
GLU A 340
HIS A  44
 None
 0.87A 5xioA-4bpsA:
undetectable		 5xioA-4bpsA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4bps FKBO
(Streptomyces
hygroscopicus) 		3 / 3 THR A 180
GLU A 340
HIS A  44
 None
 0.86A 5xiqB-4bpsA:
undetectable		 5xiqB-4bpsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 4bps FKBO
(Streptomyces
hygroscopicus) 		3 / 3 THR A 180
GLU A 340
HIS A  44
 None
 0.84A 5xiqD-4bpsA:
undetectable		 5xiqD-4bpsA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 VAL A 293
ASP A 292
ASP A 268
GLY A 287
LEU A 279
 None
 1.08A 6b0iB-4bpsA:
undetectable		 6b0iB-4bpsA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4bps FKBO
(Streptomyces
hygroscopicus) 		5 / 12 ILE A  90
ASP A  87
LEU A  99
ALA A 195
LEU A 129
 None
 1.03A 6bq4A-4bpsA:
undetectable		 6bq4A-4bpsA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4bps FKBO
(Streptomyces
hygroscopicus) 		4 / 5 LEU A 326
THR A  64
THR A  46
GLY A  45
 None
 1.25A 6gtqA-4bpsA:
undetectable		 6gtqA-4bpsA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bps FKBO
(Streptomyces
hygroscopicus) 		4 / 7 THR A  27
ARG A  67
HIS A 327
ASP A  69
 None
 1.13A 6mn4E-4bpsA:
undetectable		 6mn4E-4bpsA:
23.45