SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 5 PRO A 200
VAL A 223
TYR A 193
GLU A 190
 None
 1.23A 1m9jB-4bptA:
undetectable		 1m9jB-4bptA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 PHE A  91
GLU A 123
HIS A 127
TRP A 163
GLU A 167
 PEG  A1260 (-3.8A)
None
None
PEG  A1262 ( 4.4A)
PEG  A1261 (-3.1A)
 0.89A 1mmkA-4bptA:
26.5		 1mmkA-4bptA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 VAL A  82
PHE A  91
GLU A 123
HIS A 127
GLU A 167
 None
PEG  A1260 (-3.8A)
None
None
PEG  A1261 (-3.1A)
 0.94A 1mmkA-4bptA:
26.5		 1mmkA-4bptA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 11 VAL A  82
PHE A  91
GLU A 123
HIS A 127
GLU A 167
 None
PEG  A1260 (-3.8A)
None
None
PEG  A1261 (-3.1A)
 0.94A 1mmtA-4bptA:
26.6		 1mmtA-4bptA:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 11 PHE A  91
PHE A 162
PHE A 211
VAL A 237
PHE A 139
 PEG  A1260 (-3.8A)
None
None
None
None
 1.32A 1q23I-4bptA:
undetectable		 1q23I-4bptA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		3 / 3 VAL A 140
VAL A 135
TRP A  77
 None
 0.91A 1w5uC-4bptA:
undetectable
1w5uD-4bptA:
undetectable		 1w5uC-4bptA:
10.84
1w5uD-4bptA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 5 ILE A  61
SER A  68
ARG A  70
LEU A 124
 None
 1.07A 1y0xX-4bptA:
undetectable		 1y0xX-4bptA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 5 LEU A 124
PRO A  81
ALA A 102
ILE A 120
 None
 1.01A 2aofB-4bptA:
undetectable		 2aofB-4bptA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 TYR A  20
HIS A  10
LEU A  64
ILE A  61
GLU A  24
 None
 1.28A 2weyA-4bptA:
undetectable		 2weyA-4bptA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 7 TYR A 180
CYH A  44
GLU A  46
TYR A 230
 None
 1.35A 2xytD-4bptA:
0.0		 2xytD-4bptA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 7 TYR A 180
CYH A  44
GLU A  46
TYR A 230
 None
 1.47A 2xytH-4bptA:
undetectable		 2xytH-4bptA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		3 / 3 VAL A 140
VAL A 135
TRP A  77
 None
 0.93A 3l8lC-4bptA:
undetectable
3l8lD-4bptA:
undetectable		 3l8lC-4bptA:
10.84
3l8lD-4bptA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 5 ILE A  86
HIS A 122
GLU A 123
HIS A 127
 None
 0.97A 3ljgA-4bptA:
undetectable		 3ljgA-4bptA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		3 / 3 ARG A 160
PRO A 222
PHE A 164
 None
 1.04A 3thrC-4bptA:
undetectable		 3thrC-4bptA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 ASP A 240
ASP A 246
ARG A 249
ASP A 154
PHE A 150
 None
 1.41A 3topA-4bptA:
undetectable		 3topA-4bptA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 GLY A 126
GLY A 182
TYR A 180
PHE A 100
LEU A 124
 None
 1.23A 3vywD-4bptA:
undetectable		 3vywD-4bptA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 11 GLY A 126
GLY A 182
GLY A 181
GLN A 221
HIS A 122
 None
 1.14A 4l8fD-4bptA:
undetectable		 4l8fD-4bptA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 GLY A 183
GLY A 181
PHE A  47
ILE A 188
LEU A  31
 None
 1.17A 4n48A-4bptA:
undetectable		 4n48A-4bptA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 GLY A 183
GLY A 181
PHE A  47
ILE A 188
LEU A  31
 None
 1.18A 4n48B-4bptA:
undetectable		 4n48B-4bptA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 6 PHE A  91
HIS A 122
HIS A 127
GLU A 167
 PEG  A1260 (-3.8A)
None
None
PEG  A1261 (-3.1A)
 0.80A 4pahA-4bptA:
28.4		 4pahA-4bptA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 ALA A 144
HIS A 122
GLU A 123
HIS A 127
PHE A 162
 None
 1.19A 4r7lA-4bptA:
undetectable		 4r7lA-4bptA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 HIS A 122
GLU A 123
HIS A 127
PHE A 162
GLU A 167
 None
None
None
None
PEG  A1261 (-3.1A)
 1.18A 4r7lA-4bptA:
undetectable		 4r7lA-4bptA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		3 / 3 GLU A 117
HIS A 122
VAL A 115
 None
 0.79A 5trqB-4bptA:
undetectable		 5trqB-4bptA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		5 / 12 LEU A  54
GLY A 181
PHE A 100
ALA A 102
GLY A 183
 None
 1.04A 5veuH-4bptA:
undetectable		 5veuH-4bptA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4bpt PHENYLALANINE-4-HYDR
OXYLASE (PAH)
(PHE-4-MONOOXYGENASE
)
(Legionella
pneumophila) 		4 / 6 PRO A 118
HIS A 122
HIS A 127
GLU A 167
 None
None
None
PEG  A1261 (-3.1A)
 0.75A 6pahA-4bptA:
28.4		 6pahA-4bptA:
29.32