SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1G50_A_ESTA600_1 (ESTROGEN RECEPTOR)	4bpx	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT (Homo sapiens)	5 / 11	LEU B 106 LEU B 108 LEU B 246 ILE B 47 LEU B 253	None	1.21A	1g50A-4bpxB: undetectable	1g50A-4bpxB: 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YC2_D_NCAD510_0 (NAD-DEPENDENT DEACETYLASE 2)	4bpx	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT (Homo sapiens)	4 / 5	ALA B 224 ASN B 220 ILE B 217 ASP B 193	None	1.11A	1yc2D-4bpxB: undetectable	1yc2D-4bpxB: 23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4URO_A_NOVA2000_1 (DNA GYRASE SUBUNIT B)	4bpx	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT (Homo sapiens)	5 / 12	ASP B 193 GLN B 123 ILE B 121 SER B 227 ARG B 129	None	1.35A	4uroA-4bpxB: undetectable	4uroA-4bpxB: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F7L_B_ACTB505_0 (AMINE OXIDASE LKCE)	4bpx	DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT (Homo sapiens)	3 / 3	HIS B 252 ASN B 251 LEU B 250	None	0.89A	6f7lB-4bpxB: undetectable	6f7lB-4bpxB: 23.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1G50_A_ESTA600_1","ESTROGEN RECEPTOR","4bpx","DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT","Homo sapiens",5,"LEU B 106;LEU B 108;LEU B 246;ILE B  47;LEU B 253","None","1.21A","1g50A-4bpxB:undetectable","1g50A-4bpxB:23.16"],["1YC2_D_NCAD510_0","NAD-DEPENDENT DEACETYLASE 2","4bpx","DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT","Homo sapiens",4,"ALA B 224;ASN B 220;ILE B 217;ASP B 193","None","1.11A","1yc2D-4bpxB:undetectable","1yc2D-4bpxB:23.18"],["4URO_A_NOVA2000_1","DNA GYRASE SUBUNIT B","4bpx","DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT","Homo sapiens",5,"ASP B 193;GLN B 123;ILE B 121;SER B 227;ARG B 129","None","1.35A","4uroA-4bpxB:undetectable","4uroA-4bpxB:20.88"],["6F7L_B_ACTB505_0","AMINE OXIDASE LKCE","4bpx","DNA POLYMERASE ALPHA CATALYTIC SUBUNIT, DNA PRIMASE LARGE SUBUNIT","Homo sapiens",3,"HIS B 252;ASN B 251;LEU B 250","None","0.89A","6f7lB-4bpxB:undetectable","6f7lB-4bpxB:23.94"]]