SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		3 / 3 ASP A 377
ASP A 144
ASP A 188
 CA  A 400 (-3.2A)
None
None
 0.53A 2igtA-4bpzA:
undetectable		 2igtA-4bpzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		3 / 3 ASP A 377
ASP A 144
ASP A 188
 CA  A 400 (-3.2A)
None
None
 0.52A 2igtB-4bpzA:
undetectable		 2igtB-4bpzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		5 / 12 LEU A 214
LEU A 353
ARG A 213
ILE A 193
ALA A 240
 None
None
BGC  A 402 ( 3.9A)
None
GLC  A 401 ( 3.5A)
 1.03A 3gwvA-4bpzA:
undetectable		 3gwvA-4bpzA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		5 / 12 LEU A 329
SER A 317
TYR A 316
ILE A 306
LEU A 231
 None
 1.39A 3vw1B-4bpzA:
undetectable		 3vw1B-4bpzA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		4 / 8 SER A 248
GLU A 250
ILE A 272
VAL A 227
 None
BGC  A 402 ( 3.4A)
None
None
 0.89A 4dx7B-4bpzA:
undetectable		 4dx7B-4bpzA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		4 / 8 VAL A 227
ILE A 241
SER A 317
ALA A 285
 None
 0.97A 4eyzA-4bpzA:
undetectable		 4eyzA-4bpzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		4 / 8 VAL A 227
ILE A 241
SER A 317
ALA A 285
 None
 0.96A 4eyzB-4bpzA:
undetectable		 4eyzB-4bpzA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		4 / 8 THR A 343
PRO A 344
LEU A 337
SER A 269
 None
None
None
GLC  A 401 ( 3.5A)
 1.02A 4qknA-4bpzA:
undetectable		 4qknA-4bpzA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		3 / 3 GLU A 147
TYR A 378
ARG A 380
 CA  A 400 (-3.5A)
None
None
 0.78A 5uunA-4bpzA:
undetectable		 5uunA-4bpzA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4bpz ENDO-1,3-BETA-GLUCAN
ASE, FAMILY GH16
(Zobellia
galactanivorans) 		3 / 3 HIS A 288
ASN A 299
LEU A 300
 GLC  A 401 ( 3.3A)
None
None
 0.88A 6f7lB-4bpzA:
undetectable		 6f7lB-4bpzA:
18.55