SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bqh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 9 PHE A 403
VAL A 300
PHE A 317
PHE A 112
LEU A 399
 None
 1.07A 1wrkA-4bqhA:
undetectable
1wrkB-4bqhA:
undetectable		 1wrkA-4bqhA:
9.68
1wrkB-4bqhA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		4 / 7 ARG A  93
GLU A  98
ASN A 283
PRO A 287
 None
 1.01A 2ejgA-4bqhA:
undetectable		 2ejgA-4bqhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 11 THR A 465
SER A 493
LEU A 522
VAL A 518
ILE A 530
 None
 1.22A 2zbzA-4bqhA:
undetectable		 2zbzA-4bqhA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		3 / 3 CYH A 148
HIS A 147
PHE A 144
 None
 1.07A 3cr4X-4bqhA:
undetectable		 3cr4X-4bqhA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 10 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.16A 3elzC-4bqhA:
undetectable		 3elzC-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 10 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.12A 3em0A-4bqhA:
undetectable		 3em0A-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 530
ILE A 532
VAL A 504
GLY A 510
LEU A 463
 None
None
None
SO4  A1538 (-3.2A)
None
 1.12A 3em0B-4bqhA:
undetectable		 3em0B-4bqhA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_B_KKKB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 PHE A 531
PHE A 132
GLY A 124
ALA A 436
THR A 443
 None
 1.31A 3ld6B-4bqhA:
undetectable		 3ld6B-4bqhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 GLY A 322
SER A 416
HIS A 299
CYH A 409
GLU A 408
 None
 1.31A 3rq4A-4bqhA:
undetectable		 3rq4A-4bqhA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		4 / 7 VAL A  45
ILE A 219
ARG A 380
ILE A 220
 9VU  A1539 (-3.9A)
None
None
None
 0.66A 4uxqA-4bqhA:
undetectable		 4uxqA-4bqhA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 515
LEU A 522
ALA A 498
LYS A 497
ILE A 500
 None
 1.10A 4x1iD-4bqhA:
undetectable		 4x1iD-4bqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 LEU A 515
LEU A 522
ALA A 498
LYS A 497
ILE A 500
 None
 1.09A 4x1kD-4bqhA:
undetectable		 4x1kD-4bqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		3 / 4 ARG A 308
GLY A 309
GLU A 312
 None
 0.56A 4z2dB-4bqhA:
undetectable
4z2dC-4bqhA:
undetectable		 4z2dB-4bqhA:
22.85
4z2dC-4bqhA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 GLY A 322
SER A 416
HIS A 299
CYH A 409
GLU A 408
 None
 1.33A 5cprB-4bqhA:
undetectable		 5cprB-4bqhA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 GLU A 396
GLY A 232
SER A 177
VAL A 209
VAL A  45
 None
9VU  A1539 (-3.2A)
None
9VU  A1539 (-4.9A)
9VU  A1539 (-3.9A)
 1.14A 5dpdA-4bqhA:
2.2		 5dpdA-4bqhA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		5 / 12 ILE A 532
LEU A 503
LEU A 459
LEU A 515
LEU A 463
 None
 1.29A 5tiwA-4bqhA:
undetectable		 5tiwA-4bqhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE
(Trypanosoma
brucei) 		3 / 3 ARG A 265
PHE A 362
LEU A 261
 None
 0.88A 5x1bC-4bqhA:
undetectable		 5x1bC-4bqhA:
19.49