SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 9 VAL A 556
GLY A 613
ILE A 612
VAL A 559
ILE A 553
None
1.15A 1hpvB-4bqiA:
undetectable
1hpvB-4bqiA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 GLY A 677
VAL A 725
ALA A 680
LEU A 386
TYR A 778
None
1.18A 1kiaD-4bqiA:
undetectable
1kiaD-4bqiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 3 ARG A 319
ILE A 243
TRP A 158
None
1.22A 1m8eB-4bqiA:
undetectable
1m8eB-4bqiA:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
9 / 10 ASN A 136
LEU A 139
TYR A 285
ASP A 288
ARG A 297
ASP A 341
HIS A 343
ARG A 573
HIS A 575
None
0.60A 2ecpA-4bqiA:
50.6
2ecpA-4bqiA:
42.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
9 / 10 ASN A 136
LEU A 139
TYR A 285
ASP A 288
ARG A 297
ASP A 341
HIS A 343
ARG A 573
HIS A 575
None
0.55A 2ecpB-4bqiA:
49.3
2ecpB-4bqiA:
42.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 3 ARG A 315
SER A 314
TYR A  74
None
0.82A 2q2hA-4bqiA:
undetectable
2q2hB-4bqiA:
undetectable
2q2hA-4bqiA:
10.68
2q2hB-4bqiA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ALA A  97
GLU A 129
LEU A  55
ILE A  34
LEU A 115
None
1.28A 2zzaA-4bqiA:
undetectable
2zzaA-4bqiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 11 ALA A  97
GLU A 129
LEU A  55
ILE A  34
LEU A 115
None
1.27A 2zzaB-4bqiA:
undetectable
2zzaB-4bqiA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ILE A 832
PHE A 482
PHE A 471
LEU A 466
SER A 452
None
1.38A 3apwB-4bqiA:
undetectable
3apwB-4bqiA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 8 SER A  61
ALA A 114
ILE A  16
THR A 117
None
0.97A 3bpxA-4bqiA:
undetectable
3bpxB-4bqiA:
undetectable
3bpxA-4bqiA:
9.89
3bpxB-4bqiA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ALA A  97
GLU A 129
LEU A  55
GLN A 128
LEU A 115
None
1.13A 3datA-4bqiA:
undetectable
3datA-4bqiA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 9 VAL A 556
GLY A 613
ILE A 612
VAL A 559
ILE A 553
None
1.12A 3ekvB-4bqiA:
undetectable
3ekvB-4bqiA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 10 GLY A 701
ALA A 702
GLY A 697
LEU A 717
VAL A 710
ILE A 706
None
1.46A 3em3A-4bqiA:
undetectable
3em3A-4bqiA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ALA A  97
GLU A 129
LEU A  55
GLN A 128
LEU A 115
None
1.27A 3ia4B-4bqiA:
undetectable
3ia4B-4bqiA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 PRO A 344
SER A  89
LEU A 309
SER A 308
None
1.30A 3iluH-4bqiA:
undetectable
3iluH-4bqiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ALA A  97
GLU A 129
LEU A  55
GLN A 128
LEU A 115
None
1.16A 3ix9A-4bqiA:
undetectable
3ix9A-4bqiA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 10 ALA A  97
GLU A 129
LEU A  55
LEU A 115
ILE A 102
None
1.14A 3jw3A-4bqiA:
undetectable
3jw3A-4bqiA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 11 TYR A 111
ASN A 100
LEU A  66
ALA A  24
THR A 242
None
1.36A 3jwqB-4bqiA:
undetectable
3jwqC-4bqiA:
undetectable
3jwqB-4bqiA:
17.47
3jwqC-4bqiA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 SER A 820
LEU A 690
THR A 490
ARG A 492
PEG  A1842 (-2.5A)
None
None
PEG  A1842 ( 4.4A)
1.40A 3thrB-4bqiA:
undetectable
3thrB-4bqiA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 8 ILE A 626
LEU A 629
VAL A 587
GLY A 586
None
0.84A 3w1wA-4bqiA:
3.4
3w1wA-4bqiA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 MET A 352
TRP A 363
GLU A 407
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.31A 4bqfA-4bqiA:
64.3
4bqfA-4bqiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 6 MET A 356
GLY A 362
TRP A 363
ARG A 400
GLU A 407
ARG A 411
MLR  A 951 ( 3.7A)
MLR  A 951 (-3.6A)
None
MLR  A 951 (-2.9A)
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
0.19A 4bqfA-4bqiA:
64.3
4bqfA-4bqiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
8 / 8 ARG A 217
MET A 356
TRP A 363
ARG A 400
GLU A 403
GLU A 407
LYS A 410
ARG A 411
MLR  A 951 (-3.8A)
MLR  A 951 ( 3.7A)
None
MLR  A 951 (-2.9A)
MLR  A 951 ( 3.9A)
MLR  A 951 (-2.9A)
MLR  A 951 ( 4.4A)
MLR  A 951 (-4.1A)
0.20A 4bqfB-4bqiA:
63.6
4bqfB-4bqiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 3 LEU A 510
LYS A 511
THR A 512
None
0.39A 4lj0A-4bqiA:
undetectable
4lj0A-4bqiA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 3 PRO A 344
VAL A 374
HIS A 453
None
0.83A 4pevC-4bqiA:
4.6
4pevC-4bqiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 VAL A 559
ILE A 561
VAL A 650
THR A 609
None
0.70A 4xdtA-4bqiA:
undetectable
4xdtA-4bqiA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 5 GLY A 360
GLY A 362
GLU A 365
None
MLR  A 951 (-3.6A)
None
0.42A 4z2eA-4bqiA:
undetectable
4z2eD-4bqiA:
2.7
4z2eA-4bqiA:
19.00
4z2eD-4bqiA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ALA A 143
GLY A 135
GLY A 140
GLY A 138
LEU A 134
None
None
None
PLP  A 901 (-3.3A)
None
0.97A 5c0oH-4bqiA:
2.5
5c0oH-4bqiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 7 PHE A 302
SER A 308
ALA A 307
LEU A 304
None
0.93A 5dzkD-4bqiA:
undetectable
5dzkR-4bqiA:
undetectable
5dzkD-4bqiA:
14.15
5dzkR-4bqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 8 PHE A 302
SER A 308
ALA A 307
LEU A 304
None
0.83A 5dzkd-4bqiA:
undetectable
5dzkr-4bqiA:
undetectable
5dzkd-4bqiA:
14.15
5dzkr-4bqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 PHE A 302
SER A 308
ALA A 307
LEU A 304
None
0.96A 5dzkg-4bqiA:
1.7
5dzku-4bqiA:
undetectable
5dzkg-4bqiA:
14.15
5dzku-4bqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 PHE A 749
GLU A 596
GLU A 642
VAL A 643
None
1.35A 5h4dA-4bqiA:
2.0
5h4dA-4bqiA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 8 TYR A  87
PHE A 146
ILE A 832
TRP A 833
None
0.98A 5hw8H-4bqiA:
undetectable
5hw8H-4bqiA:
9.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 GLU A 576
THR A 619
TYR A 620
PHE A 779
None
0.39A 5lrbA-4bqiA:
60.1
5lrbA-4bqiA:
55.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LRB_B_ACRB1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 9 GLU A 576
THR A 619
TYR A 620
GLY A 774
TYR A 778
PHE A 779
None
0.47A 5lrbB-4bqiA:
60.1
5lrbB-4bqiA:
55.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 10 GLY A 138
HIS A 379
VAL A 458
ASN A 487
LYS A 578
GLU A 679
PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 ( 4.7A)
None
0.88A 5vncC-4bqiA:
16.5
5vncC-4bqiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 10 GLY A 138
HIS A 379
VAL A 458
ASN A 487
LYS A 578
GLY A 682
PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 ( 4.7A)
PLP  A 901 (-3.5A)
0.75A 5vncC-4bqiA:
16.5
5vncC-4bqiA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
3 / 3 LYS A 542
ASN A 545
SER A 499
None
1.16A 5yw0A-4bqiA:
undetectable
5yw0A-4bqiA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 LEU A 309
THR A 345
ARG A 400
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.00A 6ew0B-4bqiA:
undetectable
6ew0B-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 LEU A 309
THR A 345
ARG A 400
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.01A 6ew0D-4bqiA:
undetectable
6ew0D-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 LEU A 309
THR A 345
ARG A 400
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.01A 6ew0G-4bqiA:
undetectable
6ew0G-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 LEU A 309
THR A 345
ARG A 400
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.01A 6ew0H-4bqiA:
undetectable
6ew0H-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 5 LEU A 309
THR A 345
ARG A 400
ARG A 411
None
None
MLR  A 951 (-2.9A)
MLR  A 951 (-4.1A)
1.01A 6ew0I-4bqiA:
undetectable
6ew0I-4bqiA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 6 ASN A 638
VAL A 650
VAL A 610
THR A 609
None
1.29A 6f32B-4bqiA:
undetectable
6f32B-4bqiA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
4 / 7 ARG A 315
TYR A 160
LEU A 147
TYR A  86
None
1.33A 6g2pA-4bqiA:
0.7
6g2pA-4bqiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 12 GLY A 137
GLY A 138
ASP A 341
VAL A 458
ASN A 487
GLY A 682
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 (-3.5A)
0.77A 6gneA-4bqiA:
22.4
6gneA-4bqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 12 GLY A 138
ASP A 341
VAL A 458
ASN A 487
ARG A 573
GLY A 682
PLP  A 901 (-3.3A)
None
None
None
None
PLP  A 901 (-3.5A)
0.89A 6gneA-4bqiA:
22.4
6gneA-4bqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
7 / 12 GLU A  91
GLY A 137
GLY A 138
ASP A 341
VAL A 458
ASN A 487
GLY A 682
None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
PLP  A 901 (-3.5A)
0.74A 6gneB-4bqiA:
22.6
6gneB-4bqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
7 / 12 GLU A  91
GLY A 138
ASP A 341
VAL A 458
ASN A 487
ARG A 573
GLY A 682
None
PLP  A 901 (-3.3A)
None
None
None
None
PLP  A 901 (-3.5A)
0.83A 6gneB-4bqiA:
22.6
6gneB-4bqiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 288
ASP A 341
HIS A 343
ARG A 573
GLU A 679
None
0.78A 6gnfA-4bqiA:
22.8
6gnfA-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 288
ASP A 341
HIS A 343
ASN A 487
ARG A 573
None
0.89A 6gnfA-4bqiA:
22.8
6gnfA-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 341
HIS A 343
ASN A 487
ARG A 573
GLY A 682
None
None
None
None
PLP  A 901 (-3.5A)
0.76A 6gnfA-4bqiA:
22.8
6gnfA-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 9 GLY A 137
GLY A 138
TYR A 285
HIS A 379
VAL A 458
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
0.81A 6gnfA-4bqiA:
22.7
6gnfA-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 10 GLY A 138
LEU A 139
TYR A 285
HIS A 379
VAL A 458
PLP  A 901 (-3.3A)
None
None
None
None
0.79A 6gnfC-4bqiA:
23.0
6gnfC-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 288
ASP A 341
HIS A 343
ARG A 573
GLU A 679
None
0.77A 6gnfC-4bqiA:
23.0
6gnfC-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 288
ASP A 341
HIS A 343
ASN A 487
ARG A 573
None
0.88A 6gnfC-4bqiA:
23.0
6gnfC-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 ASP A 341
HIS A 343
ASN A 487
ARG A 573
GLY A 682
None
None
None
None
PLP  A 901 (-3.5A)
0.76A 6gnfC-4bqiA:
23.0
6gnfC-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 GLY A 137
LEU A 139
ASP A 341
HIS A 343
ASN A 487
PLP  A 901 ( 4.2A)
None
None
None
None
0.84A 6gngA-4bqiA:
22.4
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 GLY A 137
LEU A 139
GLY A 287
ASP A 341
HIS A 343
PLP  A 901 ( 4.2A)
None
None
None
None
1.08A 6gngA-4bqiA:
22.4
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
7 / 12 GLU A  91
GLY A 138
TYR A 285
HIS A 379
VAL A 458
ARG A 573
GLU A 679
None
PLP  A 901 (-3.3A)
None
None
None
None
None
0.86A 6gngA-4bqiA:
22.3
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
7 / 12 GLU A  91
GLY A 138
TYR A 285
HIS A 379
VAL A 458
ARG A 573
GLY A 682
None
PLP  A 901 (-3.3A)
None
None
None
None
PLP  A 901 (-3.5A)
0.89A 6gngA-4bqiA:
22.3
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 12 GLU A  91
GLY A 137
GLY A 138
LEU A 139
GLY A 287
HIS A 343
None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
1.04A 6gngB-4bqiA:
22.3
6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
6 / 12 GLU A  91
GLY A 137
GLY A 138
LEU A 139
HIS A 343
ARG A 573
None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
0.60A 6gngB-4bqiA:
22.3
6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 12 GLU A  91
GLY A 137
LEU A 139
GLY A 287
HIS A 343
None
PLP  A 901 ( 4.2A)
None
None
None
1.09A 6gngB-4bqiA:
22.3
6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana)
5 / 11 THR A 698
THR A 675
ARG A 742
PHE A 785
GLY A 782
None
1.47A 6nknA-4bqiA:
undetectable
6nknB-4bqiA:
undetectable
6nknT-4bqiA:
undetectable
6nknA-4bqiA:
19.38
6nknB-4bqiA:
14.81
6nknT-4bqiA:
7.26