SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 223
HIS A 239
GLY A 243
ASN A 264
GLY A 270
 None
None
None
EDO  A1467 (-3.5A)
None
 1.15A 1ffyA-4bqmA:
undetectable		 1ffyA-4bqmA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LYS A 287
LEU A 277
SER A 229
THR A 225
 None
 1.24A 1tyrA-4bqmA:
undetectable		 1tyrA-4bqmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 277
ALA A 343
ASP A 339
GLY A 325
ILE A 324
 None
 0.92A 3el5A-4bqmA:
undetectable		 3el5A-4bqmA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 422
GLY A 430
VAL A 428
LEU A 390
MET A 398
 None
 1.43A 3h52C-4bqmA:
undetectable		 3h52C-4bqmA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 430
GLY A 203
PHE A 168
PHE A 450
 None
 0.88A 3ko0M-4bqmA:
undetectable
3ko0P-4bqmA:
undetectable		 3ko0M-4bqmA:
14.58
3ko0P-4bqmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 343
ASP A 339
GLY A 325
ILE A 324
ALA A 271
 None
 0.64A 3n3iA-4bqmA:
undetectable		 3n3iA-4bqmA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 384
GLY A 234
SER A 382
 None
 0.65A 4b53B-4bqmA:
undetectable		 4b53B-4bqmA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 397
MET A 398
PHE A 334
GLY A 325
LEU A 254
 None
 1.04A 4ze1A-4bqmA:
undetectable		 4ze1A-4bqmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 274
LEU A 422
LEU A 224
SER A 229
LEU A 367
 None
 1.15A 5hnwB-4bqmA:
undetectable		 5hnwB-4bqmA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 274
LEU A 422
LEU A 224
SER A 229
LEU A 367
 None
 1.21A 5hnyB-4bqmA:
undetectable		 5hnyB-4bqmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4bqm GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ALA A 343
ASP A 339
GLY A 325
ILE A 324
 None
 0.66A 5kqyB-4bqmA:
undetectable		 5kqyB-4bqmA:
17.69