SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 PRO A  67
VAL A  68
VAL A  95
ILE A  49
GLY A  12
 None
COA  A 320 (-3.9A)
None
None
None
 1.35A 13gsA-4bqnA:
undetectable		 13gsA-4bqnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_B_SASB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 9 PRO A  67
VAL A  68
VAL A  95
ILE A  49
GLY A  12
 None
COA  A 320 (-3.9A)
None
None
None
 1.35A 13gsB-4bqnA:
undetectable		 13gsB-4bqnA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ILE A 156
ILE A 153
ARG A 308
ALA A 147
GLU A 155
 None
None
CL  A1315 (-4.1A)
None
None
 1.25A 1ki7B-4bqnA:
undetectable		 1ki7B-4bqnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 LEU A 164
LEU A 206
TRP A 100
PHE A 196
 COA  A 320 ( 4.7A)
None
None
None
 1.32A 1ru9H-4bqnA:
undetectable
1ru9L-4bqnA:
undetectable		 1ru9H-4bqnA:
18.75
1ru9L-4bqnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 LEU A 164
LEU A 206
TRP A 100
PHE A 196
 COA  A 320 ( 4.7A)
None
None
None
 1.34A 1rukH-4bqnA:
undetectable
1rukL-4bqnA:
undetectable		 1rukH-4bqnA:
18.75
1rukL-4bqnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_SAMB293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 TYR A 120
ALA A  18
ASP A 232
TYR A 197
TYR A  97
 None
None
None
None
COA  A 320 (-3.6A)
 1.28A 1xvaB-4bqnA:
undetectable		 1xvaB-4bqnA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 LEU A  60
GLN A  66
LEU A  19
LEU A  35
THR A  56
 None
 1.38A 1zucA-4bqnA:
undetectable		 1zucA-4bqnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		3 / 3 TRP A 279
LYS A 267
PRO A 117
 None
 1.29A 2dqyB-4bqnA:
undetectable		 2dqyB-4bqnA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 8 ALA A  20
LEU A  23
TYR A  65
ILE A 178
 None
 0.86A 3cldB-4bqnA:
undetectable		 3cldB-4bqnA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ASP A 173
SER A  79
LEU A  19
ILE A 210
ASP A 179
 None
 1.45A 3ko0A-4bqnA:
undetectable
3ko0B-4bqnA:
undetectable
3ko0C-4bqnA:
undetectable
3ko0D-4bqnA:
undetectable		 3ko0A-4bqnA:
17.38
3ko0B-4bqnA:
17.38
3ko0C-4bqnA:
17.38
3ko0D-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ASP A 179
LEU A  19
ILE A 210
ASP A 173
SER A  79
 None
 1.44A 3ko0C-4bqnA:
undetectable
3ko0D-4bqnA:
undetectable
3ko0E-4bqnA:
undetectable
3ko0F-4bqnA:
undetectable		 3ko0C-4bqnA:
17.38
3ko0D-4bqnA:
17.38
3ko0E-4bqnA:
17.38
3ko0F-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ASP A 173
SER A  79
LEU A  19
ILE A 210
ASP A 179
 None
 1.35A 3ko0C-4bqnA:
undetectable
3ko0D-4bqnA:
undetectable
3ko0E-4bqnA:
undetectable
3ko0F-4bqnA:
undetectable		 3ko0C-4bqnA:
17.38
3ko0D-4bqnA:
17.38
3ko0E-4bqnA:
17.38
3ko0F-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ASP A 179
LEU A  19
ILE A 210
ASP A 173
SER A  79
 None
 1.39A 3ko0E-4bqnA:
undetectable
3ko0F-4bqnA:
undetectable
3ko0G-4bqnA:
undetectable
3ko0H-4bqnA:
undetectable		 3ko0E-4bqnA:
17.38
3ko0F-4bqnA:
17.38
3ko0G-4bqnA:
17.38
3ko0H-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 12 ASP A 179
LEU A  19
ILE A 210
ASP A 173
SER A  79
 None
 1.44A 3ko0G-4bqnA:
undetectable
3ko0H-4bqnA:
undetectable
3ko0I-4bqnA:
undetectable
3ko0J-4bqnA:
undetectable		 3ko0G-4bqnA:
17.38
3ko0H-4bqnA:
17.38
3ko0I-4bqnA:
17.38
3ko0J-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 LEU A  19
ILE A 210
ASP A 179
ASP A 173
SER A  79
 None
 1.41A 3ko0O-4bqnA:
undetectable
3ko0P-4bqnA:
undetectable
3ko0Q-4bqnA:
undetectable
3ko0R-4bqnA:
undetectable		 3ko0O-4bqnA:
17.38
3ko0P-4bqnA:
17.38
3ko0Q-4bqnA:
17.38
3ko0R-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 ASP A 173
SER A  79
LEU A  19
ILE A 210
ASP A 179
 None
 1.39A 3ko0O-4bqnA:
undetectable
3ko0P-4bqnA:
undetectable
3ko0Q-4bqnA:
undetectable
3ko0R-4bqnA:
undetectable		 3ko0O-4bqnA:
17.38
3ko0P-4bqnA:
17.38
3ko0Q-4bqnA:
17.38
3ko0R-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 ASP A 173
SER A  79
ASP A 179
LEU A  19
ILE A 210
 None
 1.40A 3ko0Q-4bqnA:
undetectable
3ko0R-4bqnA:
undetectable
3ko0S-4bqnA:
undetectable
3ko0T-4bqnA:
undetectable		 3ko0Q-4bqnA:
17.38
3ko0R-4bqnA:
17.38
3ko0S-4bqnA:
17.38
3ko0T-4bqnA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 11 TYR A   8
LEU A  62
VAL A  10
ALA A 211
ALA A 217
 None
 0.86A 3mdtB-4bqnA:
undetectable		 3mdtB-4bqnA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 GLN A  96
PHE A 196
PRO A 202
LEU A 195
 None
 1.31A 3tgvB-4bqnA:
undetectable		 3tgvB-4bqnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 6 GLN A  96
PHE A 196
PRO A 202
LEU A 195
 None
 1.30A 3tgvD-4bqnA:
undetectable		 3tgvD-4bqnA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		4 / 4 ASP A 122
LEU A 273
ARG A 256
THR A 106
 None
 1.40A 4kjkA-4bqnA:
undetectable		 4kjkA-4bqnA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 4bqn CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Burkholderia
pseudomallei) 		5 / 10 ASP A 173
ALA A  16
TYR A  65
SER A  79
GLY A  12
 None
 1.24A 4xp1A-4bqnA:
undetectable		 4xp1A-4bqnA:
20.94