SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4br6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		5 / 12 TYR A 177
ASN A  80
LEU A  81
MET A 157
TYR A   9
 None
 1.36A 1mrlB-4br6A:
undetectable
1mrlC-4br6A:
undetectable		 1mrlB-4br6A:
20.18
1mrlC-4br6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		6 / 12 SER A 124
GLN A 146
LEU A  81
HIS A  74
ILE A  22
ALA A 165
 None
None
None
MN3  A 301 (-3.5A)
None
None
 1.17A 2bxcA-4br6A:
undetectable		 2bxcA-4br6A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		3 / 3 GLU A  79
HIS A  74
HIS A  71
 None
MN3  A 301 (-3.5A)
None
 0.89A 3co4A-4br6A:
undetectable		 3co4A-4br6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		4 / 7 MET A  23
ILE A  18
TYR A  17
ILE A 181
 None
 1.02A 3hgxA-4br6A:
undetectable		 3hgxA-4br6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		5 / 12 SER A 135
LEU A 129
PHE A 104
PHE A 194
ALA A  99
 None
 1.21A 3u9fG-4br6A:
undetectable
3u9fH-4br6A:
undetectable		 3u9fG-4br6A:
21.70
3u9fH-4br6A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		3 / 3 ARG A 173
GLU A 171
ASN A 172
 None
NA  A 801 (-4.2A)
None
 0.85A 4imaD-4br6A:
undetectable		 4imaD-4br6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		3 / 3 ARG A 173
GLU A 171
ASN A 172
 None
NA  A 801 (-4.2A)
None
 0.84A 4ip7D-4br6A:
undetectable		 4ip7D-4br6A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		4 / 6 ILE A  18
TYR A 177
PHE A  77
ASN A  80
 None
 1.46A 4o7gB-4br6A:
undetectable		 4o7gB-4br6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		5 / 12 ILE A 159
ARG A 111
ALA A 175
ASN A 115
PHE A  77
 None
 1.49A 4zo1X-4br6A:
undetectable		 4zo1X-4br6A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4br6 SUPEROXIDE DISMUTASE
(Chaetomium
thermophilum) 		4 / 7 THR A 189
LEU A 138
VAL A 141
GLN A 113
 None
 1.05A 5tudA-4br6A:
undetectable		 5tudA-4br6A:
17.71