SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4brj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 8 HIS A 112
GLU A  23
HIS A  56
ALA A  22
 FE  A1125 (-3.3A)
FE  A1125 (-3.9A)
FE  A1125 (-3.5A)
None
 0.81A 2bnnA-4brjA:
undetectable
2bnnB-4brjA:
undetectable		 2bnnA-4brjA:
19.80
2bnnB-4brjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQE_A_CUA603_0
(BLUE COPPER OXIDASE
CUEO)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.33A 2fqeA-4brjA:
undetectable		 2fqeA-4brjA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 6 ALA A  22
ILE A  19
HIS A  25
HIS A  56
 None
None
FE  A1125 (-3.3A)
FE  A1125 (-3.5A)
 0.84A 3nneG-4brjA:
undetectable		 3nneG-4brjA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1004_0
(BLUE COPPER OXIDASE
CUEO)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  25
HIS A 112
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.41A 4ef3A-4brjA:
undetectable		 4ef3A-4brjA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.26A 5mi2A-4brjA:
2.4		 5mi2A-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.26A 5miaA-4brjA:
2.4		 5miaA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.27A 5mibA-4brjA:
2.4		 5mibA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.26A 5micA-4brjA:
2.4		 5micA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.26A 5midA-4brjA:
undetectable		 5midA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.26A 5mieA-4brjA:
2.4		 5mieA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA603_0
(LACCASE 2)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  56
HIS A 112
HIS A  25
HIS A  50
 FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
FE  A1125 (-3.3A)
FE  A1125 (-3.2A)
 1.25A 5migA-4brjA:
2.4		 5migA-4brjA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A  25
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.26A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A 112
CYH A 109
HIS A  56
HIS A  25
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.3A)
 1.45A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 4 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.20A 5zrdA-4brjA:
undetectable		 5zrdA-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 5 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.14A 5zrdB-4brjA:
undetectable		 5zrdB-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 5 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.22A 5zrdC-4brjA:
3.7		 5zrdC-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		4 / 5 HIS A 112
CYH A 109
HIS A  56
HIS A  50
 FE  A1125 (-3.3A)
FE  A1125 (-2.6A)
FE  A1125 (-3.5A)
FE  A1125 (-3.2A)
 1.14A 5zrdD-4brjA:
3.6		 5zrdD-4brjA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		5 / 10 VAL A  43
ALA A  31
LEU A  95
LEU A  97
LEU A  63
 None
 0.80A 6f5uA-4brjA:
undetectable
6f5uB-4brjA:
undetectable		 6f5uA-4brjA:
22.58
6f5uB-4brjA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION
(Ignicoccus
hospitalis) 		5 / 10 VAL A  43
ALA A  31
LEU A  95
LEU A  97
LEU A  63
 None
 0.76A 6f6nA-4brjA:
undetectable
6f6nB-4brjA:
undetectable		 6f6nA-4brjA:
22.58
6f6nB-4brjA:
24.62