SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.97A 1dhiA-4bruA:
undetectable		 1dhiA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.95A 1dhiB-4bruA:
undetectable		 1dhiB-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.99A 1dhjA-4bruA:
undetectable		 1dhjA-4bruA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 1.03A 1dhjB-4bruA:
undetectable		 1dhjB-4bruA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.95A 1draB-4bruA:
undetectable		 1draB-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.98A 1drbA-4bruA:
undetectable		 1drbA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.98A 1drbB-4bruA:
undetectable		 1drbB-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.87A 1dyrA-4bruA:
undetectable		 1dyrA-4bruA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.08A 1dz4A-4bruA:
undetectable		 1dz4A-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 1dz4B-4bruA:
undetectable		 1dz4B-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 100
VAL A 133
VAL A 121
ASP A 195
 None
 1.25A 1dz6B-4bruA:
undetectable		 1dz6B-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 1dz6B-4bruA:
undetectable		 1dz6B-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  81
ALA A  76
ILE A 193
PRO A 103
 None
 0.96A 1oniB-4bruA:
undetectable
1oniC-4bruA:
1.3		 1oniB-4bruA:
17.65
1oniC-4bruA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 1ra2A-4bruA:
undetectable		 1ra2A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.94A 1ra3A-4bruA:
undetectable		 1ra3A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 1ra8A-4bruA:
undetectable		 1ra8A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 1rb2A-4bruA:
undetectable		 1rb2A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 1rb3A-4bruA:
undetectable		 1rb3A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 1rb3B-4bruA:
undetectable		 1rb3B-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 1rd7A-4bruA:
undetectable		 1rd7A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.89A 1rd7B-4bruA:
undetectable		 1rd7B-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.93A 1re7A-4bruA:
undetectable		 1re7A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.87A 1re7B-4bruA:
undetectable		 1re7B-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.89A 1rx2A-4bruA:
undetectable		 1rx2A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 1rx7A-4bruA:
undetectable		 1rx7A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.06A 1t85A-4bruA:
undetectable		 1t85A-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.03A 1yrcA-4bruA:
undetectable		 1yrcA-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 337
VAL A 355
ILE A 371
GLY A 372
ILE A 287
 None
 0.88A 2avsA-4bruA:
undetectable		 2avsA-4bruA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 337
VAL A 355
ILE A 371
GLY A 372
ILE A 287
 None
 0.83A 2avvD-4bruA:
undetectable		 2avvD-4bruA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 2d0kA-4bruA:
undetectable		 2d0kA-4bruA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 2d0kB-4bruA:
undetectable		 2d0kB-4bruA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 261
ILE A 406
ALA A 407
ILE A 258
ILE A 371
 None
 1.13A 2dm6A-4bruA:
2.7
2dm6B-4bruA:
2.7		 2dm6A-4bruA:
23.20
2dm6B-4bruA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.97A 2drcB-4bruA:
undetectable		 2drcB-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 100
VAL A 133
VAL A 121
ASP A 195
ILE A 119
 None
 1.46A 2qbmA-4bruA:
undetectable		 2qbmA-4bruA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 100
VAL A 133
VAL A 121
ASP A 195
ILE A 119
 None
 1.48A 2qboA-4bruA:
undetectable		 2qboA-4bruA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.05A 2zawA-4bruA:
undetectable		 2zawA-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.06A 2zaxA-4bruA:
undetectable		 2zaxA-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.95A 3drcB-4bruA:
undetectable		 3drcB-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.04A 3fwgA-4bruA:
undetectable		 3fwgA-4bruA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 3fwgB-4bruA:
undetectable		 3fwgB-4bruA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.95A 3qgtB-4bruA:
undetectable		 3qgtB-4bruA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.88A 3ql3A-4bruA:
undetectable		 3ql3A-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  98
GLY A  95
THR A  94
GLN A  73
 None
 0.96A 3rglA-4bruA:
undetectable		 3rglA-4bruA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 3tq8A-4bruA:
undetectable		 3tq8A-4bruA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 3tq9A-4bruA:
undetectable		 3tq9A-4bruA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.08A 3wrhE-4bruA:
undetectable		 3wrhE-4bruA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.08A 3wrjE-4bruA:
undetectable		 3wrjE-4bruA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.96A 4dfrB-4bruA:
undetectable		 4dfrB-4bruA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.09A 4ek1A-4bruA:
undetectable		 4ek1A-4bruA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.96A 4fhbA-4bruA:
undetectable		 4fhbA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 413
GLN A 260
LEU A 382
VAL A 354
ILE A 288
 None
 1.01A 4g1bD-4bruA:
2.7		 4g1bD-4bruA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.08A 4g3rA-4bruA:
undetectable		 4g3rA-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.11A 4g3rB-4bruA:
undetectable		 4g3rB-4bruA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.89A 4kjlA-4bruA:
undetectable		 4kjlA-4bruA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.07A 4kkyX-4bruA:
undetectable		 4kkyX-4bruA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 192
ALA A 117
LEU A 213
PHE A 236
GLY A  83
 None
 1.25A 4kykA-4bruA:
undetectable
4kykB-4bruA:
undetectable		 4kykA-4bruA:
18.48
4kykB-4bruA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 100
VAL A 134
VAL A 121
ASP A 195
 None
 1.08A 4l4cA-4bruA:
undetectable		 4l4cA-4bruA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 223
ALA A  80
ALA A 117
ILE A 119
ILE A 167
 None
 0.96A 4o2bB-4bruA:
undetectable		 4o2bB-4bruA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 223
ALA A  80
ALA A 117
ILE A 119
ILE A 167
 None
 0.95A 4o2bD-4bruA:
undetectable		 4o2bD-4bruA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 124
THR A 149
THR A 152
ASP A 157
 None
 1.16A 4oltA-4bruA:
undetectable		 4oltA-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 124
THR A 149
THR A 152
ASP A 157
 None
 1.19A 4oltB-4bruA:
undetectable		 4oltB-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.89A 4pthA-4bruA:
undetectable		 4pthA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.86A 4ptjA-4bruA:
undetectable		 4ptjA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 124
THR A 149
THR A 152
ASP A 157
 None
 1.21A 4qwpA-4bruA:
undetectable		 4qwpA-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 124
THR A 149
THR A 152
ASP A 157
 None
 1.14A 4qwpB-4bruA:
undetectable		 4qwpB-4bruA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 147
LEU A 213
LEU A 186
THR A 149
ALA A 179
 None
 1.08A 4x1kA-4bruA:
2.4
4x1kB-4bruA:
undetectable		 4x1kA-4bruA:
22.15
4x1kB-4bruA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 4x5gB-4bruA:
undetectable		 4x5gB-4bruA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.93A 4x5iA-4bruA:
undetectable		 4x5iA-4bruA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 4x5jA-4bruA:
undetectable		 4x5jA-4bruA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.91A 5e8qA-4bruA:
undetectable		 5e8qA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.95A 5eajA-4bruA:
undetectable		 5eajA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 223
ALA A  80
ALA A 117
ILE A 119
ILE A 167
 None
 0.97A 5mioB-4bruA:
undetectable		 5mioB-4bruA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 314
VAL A 296
SER A 340
ILE A 371
VAL A 355
 None
 1.12A 5n0sB-4bruA:
undetectable		 5n0sB-4bruA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.93A 5ujxA-4bruA:
undetectable		 5ujxA-4bruA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.89A 5z6jA-4bruA:
undetectable		 5z6jA-4bruA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.92A 5z6kA-4bruA:
undetectable		 5z6kA-4bruA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 179
VAL A 175
THR A 148
ILE A 119
LEU A 118
 None
 1.27A 6h1lB-4bruA:
undetectable		 6h1lB-4bruA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4bru ATP-DEPENDENT RNA
HELICASE DHH1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 356
ALA A 286
ILE A 413
ILE A 384
THR A 336
 None
 0.88A 7dfrA-4bruA:
undetectable		 7dfrA-4bruA:
18.51