SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4brz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 LEU A  42
SER A 176
ILE A 177
ARG A 179
LEU A 181
 None
 1.28A 1dreA-4brzA:
undetectable		 1dreA-4brzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 THR A 203
THR A 205
PRO A 202
 None
 0.76A 1dscC-4brzA:
undetectable		 1dscC-4brzA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 THR A 203
THR A 205
PRO A 202
 None
 0.84A 1unjW-4brzA:
undetectable		 1unjW-4brzA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 THR A 203
THR A 205
PRO A 202
 None
 0.85A 1unmE-4brzA:
undetectable		 1unmE-4brzA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 THR A  13
ASP A  71
SER A  73
 None
 0.73A 2nxeA-4brzA:
undetectable		 2nxeA-4brzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 THR A  13
ASP A  71
SER A  73
 None
 0.80A 2nxeB-4brzA:
undetectable		 2nxeB-4brzA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		3 / 3 VAL A 162
ASN A  36
TRP A 107
 None
CL  A1293 (-4.4A)
CL  A1293 (-4.7A)
 1.04A 2y00B-4brzA:
undetectable		 2y00B-4brzA:
22.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		6 / 9 ASN A  36
ASP A 106
TRP A 107
PHE A 150
PHE A 168
HIS A 271
 CL  A1293 (-4.4A)
CL  A1293 ( 4.7A)
CL  A1293 (-4.7A)
CL  A1293 (-4.8A)
CL  A1293 (-4.7A)
None
 0.70A 3fbwA-4brzA:
43.6		 3fbwA-4brzA:
47.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 LEU A  42
SER A 176
ILE A 177
ARG A 179
LEU A 181
 None
 1.31A 3ia4A-4brzA:
undetectable		 3ia4A-4brzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 LEU A  42
SER A 176
ILE A 177
ARG A 179
LEU A 181
 None
 1.32A 3ia4B-4brzA:
undetectable		 3ia4B-4brzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		4 / 5 TYR A  78
THR A  79
ARG A 208
LEU A 204
 None
 1.04A 3qelC-4brzA:
2.5		 3qelC-4brzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 10 ILE A  30
LEU A  50
THR A 101
GLY A 125
SER A 291
 None
 1.01A 4bwlC-4brzA:
undetectable		 4bwlC-4brzA:
23.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 8 ASN A  36
ASP A 106
TRP A 107
PHE A 168
HIS A 271
 CL  A1293 (-4.4A)
CL  A1293 ( 4.7A)
CL  A1293 (-4.7A)
CL  A1293 (-4.7A)
None
 0.29A 4f5zA-4brzA:
43.7		 4f5zA-4brzA:
47.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		4 / 8 ASP A 106
TRP A 107
PHE A 150
HIS A 271
 CL  A1293 ( 4.7A)
CL  A1293 (-4.7A)
CL  A1293 (-4.8A)
None
 1.12A 4f5zA-4brzA:
43.7		 4f5zA-4brzA:
47.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		5 / 12 ASP A 224
THR A 135
ILE A 240
PHE A 113
TYR A 226
 None
 1.43A 5dlvA-4brzA:
undetectable		 5dlvA-4brzA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 4brz HALOALKANE
DEHALOGENASE
(Rhodobacteraceae) 		4 / 6 ARG A 208
GLY A 158
THR A 203
VAL A 162
 None
 1.21A 5ysiA-4brzA:
undetectable		 5ysiA-4brzA:
21.83