SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 9 LEU A 720
LEU A 723
GLU A 508
LYS A 512
ILE A 458
 None
 1.06A 1gx8A-4bs9A:
undetectable		 1gx8A-4bs9A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 12 GLN A 265
ASN A 129
LEU A 130
VAL A 189
TYR A 167
 None
 1.26A 1u72A-4bs9A:
undetectable		 1u72A-4bs9A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 6 ARG A 123
PRO A 191
LYS A 190
THR A 164
 None
 1.35A 2m2oB-4bs9A:
undetectable		 2m2oB-4bs9A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 7 GLU A  48
GLN A   7
VAL A  83
ALA A   5
 None
 1.03A 3kp6B-4bs9A:
3.6		 3kp6B-4bs9A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 12 LEU A 264
ALA A 267
LEU A 198
LEU A 196
ILE A 126
 None
 1.06A 3olsB-4bs9A:
undetectable		 3olsB-4bs9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 5 GLU A 721
LEU A 720
GLN A 462
GLY A 743
 None
 1.12A 3pp1A-4bs9A:
undetectable		 3pp1A-4bs9A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 8 VAL A 372
ASP A 442
GLN A 440
ARG A 330
 None
 1.06A 3uy4A-4bs9A:
undetectable		 3uy4A-4bs9A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 10 VAL A 115
LEU A 163
VAL A 161
LEU A 264
VAL A 189
 None
 0.98A 4e3hA-4bs9A:
undetectable		 4e3hA-4bs9A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		3 / 3 ASP A 603
TRP A 700
SER A 561
 None
 0.98A 4lrhA-4bs9A:
undetectable		 4lrhA-4bs9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 12 ASP A 442
PHE A 439
GLY A 331
ASP A 499
THR A 516
 None
 1.19A 4mm4A-4bs9A:
undetectable		 4mm4A-4bs9A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 11 ILE A 271
GLN A 265
LEU A 134
ALA A 133
LEU A 293
 None
 1.12A 4nqaA-4bs9A:
undetectable		 4nqaA-4bs9A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 5 GLY A 295
ALA A 294
GLY A 199
PRO A 200
 None
 0.95A 4u9uB-4bs9A:
2.4		 4u9uB-4bs9A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		3 / 3 SER A 561
GLU A 647
GLU A 430
 None
 0.84A 4ymgB-4bs9A:
undetectable		 4ymgB-4bs9A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 12 GLU A 558
LEU A 734
GLN A 727
ARG A 559
GLY A 538
 None
 1.19A 5m50E-4bs9A:
undetectable		 5m50E-4bs9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		3 / 3 GLY A 371
THR A 374
ASN A 220
 None
 0.54A 5odiG-4bs9A:
3.6		 5odiG-4bs9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		5 / 12 ALA A 254
GLY A 193
SER A 194
ASP A 166
TYR A 167
 None
 1.40A 5vlmF-4bs9A:
undetectable		 5vlmF-4bs9A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 6 GLU A 333
ARG A 330
ARG A 329
ASP A 726
 None
 1.21A 5zw4A-4bs9A:
undetectable		 5zw4A-4bs9A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 7 ILE A 122
VAL A 127
PRO A 191
THR A 114
 None
 0.96A 6cduF-4bs9A:
undetectable
6cduG-4bs9A:
undetectable		 6cduF-4bs9A:
19.08
6cduG-4bs9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 6 TRP A 565
TRP A 600
ALA A 684
LEU A 602
 None
 1.01A 6fosA-4bs9A:
undetectable		 6fosA-4bs9A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 8 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.06A 6mn4A-4bs9A:
undetectable		 6mn4A-4bs9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 7 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.14A 6mn4E-4bs9A:
undetectable		 6mn4E-4bs9A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_F_AM2F301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4bs9 TRUD
(uncultured
Prochloron
sp.
06037A) 		4 / 7 TRP A 747
HIS A 485
HIS A 465
ASP A 535
 None
 1.03A 6mn4F-4bs9A:
undetectable		 6mn4F-4bs9A:
16.34