SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 520
LEU A 517
ILE A 504
GLY A 502
LEU A 497
 None
 0.99A 1cqeA-4bsnA:
undetectable		 1cqeA-4bsnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 520
LEU A 517
ILE A 504
GLY A 502
LEU A 497
 None
 0.99A 1cqeB-4bsnA:
undetectable		 1cqeB-4bsnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 9 ALA A 224
ASN A 131
ILE A 110
ILE A 170
THR A 225
 None
 1.25A 1j3jB-4bsnA:
undetectable		 1j3jB-4bsnA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 4 HIS A 481
VAL A 484
THR A 519
LEU A 525
 None
 1.47A 1oq5A-4bsnA:
undetectable		 1oq5A-4bsnA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 351
LEU A 347
LEU A 343
TYR A 372
MET A 291
 None
 1.27A 1sqnA-4bsnA:
undetectable		 1sqnA-4bsnA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 497
LEU A 569
ILE A 501
VAL A 565
ILE A 591
 None
 1.04A 3frqB-4bsnA:
2.3		 3frqB-4bsnA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 7 LYS A 594
TYR A 551
HIS A 466
ALA A 507
 None
 1.44A 3frqB-4bsnA:
2.6		 3frqB-4bsnA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 520
LEU A 517
LEU A 480
ILE A 504
GLY A 502
 None
 1.18A 3kk6B-4bsnA:
undetectable		 3kk6B-4bsnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 520
LEU A 517
ILE A 504
GLY A 502
LEU A 497
 None
 1.07A 3n8zB-4bsnA:
undetectable		 3n8zB-4bsnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 5 LEU A 268
ALA A 272
THR A 290
PHE A 329
 None
 1.39A 3vasB-4bsnA:
undetectable		 3vasB-4bsnA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 4 ILE A 170
ASN A 166
ILE A 111
VAL A 107
 None
 1.23A 4uy87-4bsnA:
undetectable		 4uy87-4bsnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 6 ILE A 547
TYR A 551
PHE A 516
THR A 472
 None
 1.10A 5g08A-4bsnA:
undetectable		 5g08A-4bsnA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4bsn EXPORTIN-1
(Homo
sapiens) 		3 / 3 ILE A 501
ILE A 521
MET A 476
 None
 0.55A 5i9yA-4bsnA:
undetectable		 5i9yA-4bsnA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 6 ASP A 716
ARG A 712
ASN A 695
GLN A 709
 None
 1.29A 5l6eA-4bsnA:
undetectable		 5l6eA-4bsnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4bsn EXPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 580
HIS A 577
ALA A 538
SER A 542
GLN A 437
 None
 1.41A 5syfB-4bsnA:
undetectable		 5syfB-4bsnA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 5 LEU A 233
LEU A 230
MET A 213
TYR A 240
 None
 1.43A 5uc3A-4bsnA:
undetectable		 5uc3A-4bsnA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4bsn EXPORTIN-1
(Homo
sapiens) 		4 / 5 SER A 264
VAL A 263
ASN A 262
PRO A 258
 None
 1.15A 6fi4A-4bsnA:
4.5
6fi4B-4bsnA:
undetectable		 6fi4A-4bsnA:
12.62
6fi4B-4bsnA:
0.52