SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		5 / 11 VAL A 208
TYR A 113
LEU A 211
LEU A 135
THR A 175
 None
 1.33A 1dmyA-4bt6A:
undetectable		 1dmyA-4bt6A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.84A 1os2A-4bt6A:
undetectable		 1os2A-4bt6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.81A 1os2D-4bt6A:
undetectable		 1os2D-4bt6A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		5 / 10 HIS A 196
GLU A  65
HIS A 207
HIS A 194
ALA A  94
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
None
 1.12A 1r55A-4bt6A:
undetectable		 1r55A-4bt6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.85A 1uttA-4bt6A:
undetectable		 1uttA-4bt6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.84A 1utzA-4bt6A:
undetectable		 1utzA-4bt6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.80A 1utzB-4bt6A:
undetectable		 1utzB-4bt6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 6 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.83A 1y93A-4bt6A:
undetectable		 1y93A-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		5 / 12 PHE A 213
LEU A 135
LEU A 218
GLU A 121
LEU A 120
 None
 1.14A 2bxfA-4bt6A:
undetectable		 2bxfA-4bt6A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.82A 2hu6A-4bt6A:
undetectable		 2hu6A-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 6 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.88A 2ow9A-4bt6A:
undetectable		 2ow9A-4bt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.89A 2ow9B-4bt6A:
undetectable		 2ow9B-4bt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.86A 2ozrC-4bt6A:
undetectable		 2ozrC-4bt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.90A 2ozrD-4bt6A:
undetectable		 2ozrD-4bt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.90A 2ozrE-4bt6A:
undetectable		 2ozrE-4bt6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 8 GLY A 206
HIS A 207
ILE A  59
HIS A 194
 None
ZN  A1257 ( 3.2A)
None
ZN  A1257 ( 3.3A)
 0.93A 2x0pA-4bt6A:
undetectable		 2x0pA-4bt6A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.87A 3kecA-4bt6A:
undetectable		 3kecA-4bt6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 LEU A  62
HIS A 196
GLU A  65
HIS A 207
 None
ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
 0.97A 3kecA-4bt6A:
undetectable		 3kecA-4bt6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.82A 3likA-4bt6A:
undetectable		 3likA-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.81A 3lilA-4bt6A:
undetectable		 3lilA-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.78A 3ljgA-4bt6A:
undetectable		 3ljgA-4bt6A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.83A 3lkaA-4bt6A:
undetectable		 3lkaA-4bt6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 VAL A 190
PHE A  93
PHE A  39
VAL A 160
 None
None
None
GOL  A1260 ( 3.9A)
 1.35A 3rv5C-4bt6A:
undetectable
3rv5D-4bt6A:
undetectable		 3rv5C-4bt6A:
16.82
3rv5D-4bt6A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		5 / 12 HIS A 207
VAL A 147
HIS A 194
HIS A 250
LEU A 157
 ZN  A1257 ( 3.2A)
GOL  A1258 (-4.2A)
ZN  A1257 ( 3.3A)
None
None
 1.25A 3wfhA-4bt6A:
undetectable
3wfhB-4bt6A:
undetectable		 3wfhA-4bt6A:
25.82
3wfhB-4bt6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 LEU A  62
HIS A 196
GLU A  65
HIS A 207
 None
ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
 0.91A 4a7bB-4bt6A:
undetectable		 4a7bB-4bt6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 6 HIS A 196
GLY A 206
ALA A 144
GLU A 255
 ZN  A1257 ( 3.3A)
None
None
None
 0.95A 4ae1A-4bt6A:
undetectable		 4ae1A-4bt6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		3 / 3 LYS A 104
PRO A 101
LYS A 134
 None
 1.39A 4duzL-4bt6A:
undetectable		 4duzL-4bt6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 8 PHE A 167
GLN A  75
GLY A  64
THR A 146
 None
 0.99A 4k87A-4bt6A:
undetectable		 4k87A-4bt6A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 6 ASN A 210
MET A 141
GLU A 168
GLU A 166
 None
 1.47A 4r87H-4bt6A:
undetectable		 4r87H-4bt6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		5 / 10 VAL A 147
GLU A  65
VAL A 160
LEU A 209
LEU A 157
 GOL  A1258 (-4.2A)
GOL  A1258 (-2.7A)
GOL  A1260 ( 3.9A)
None
None
 1.24A 4yb6B-4bt6A:
undetectable
4yb6C-4bt6A:
undetectable		 4yb6B-4bt6A:
20.87
4yb6C-4bt6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 4 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.82A 5n5jA-4bt6A:
undetectable		 5n5jA-4bt6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		4 / 5 HIS A 196
GLU A  65
HIS A 207
HIS A 194
 ZN  A1257 ( 3.3A)
GOL  A1258 (-2.7A)
ZN  A1257 ( 3.2A)
ZN  A1257 ( 3.3A)
 0.82A 5n5kA-4bt6A:
undetectable		 5n5kA-4bt6A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4bt6 ALPHA-ACETOLACTATE
DECARBOXYLASE
(Brevibacillus
brevis) 		3 / 3 ALA A  94
PHE A  26
GLN A 229
 None
 0.74A 6eceA-4bt6A:
undetectable		 6eceA-4bt6A:
22.30