SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4btm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  54
VAL A  60
TRP A  58
 None
 0.73A 1av2C-4btmA:
undetectable
1av2D-4btmA:
undetectable		 1av2C-4btmA:
4.00
1av2D-4btmA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 SER A 153
THR A 154
PHE A 332
GLU A 330
 None
 1.25A 1icrA-4btmA:
undetectable
1icrB-4btmA:
undetectable		 1icrA-4btmA:
20.00
1icrB-4btmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 GLU A 330
SER A 153
THR A 154
PHE A 332
 None
 1.28A 1icrA-4btmA:
undetectable
1icrB-4btmA:
undetectable		 1icrA-4btmA:
20.00
1icrB-4btmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 SER A 153
THR A 154
PHE A 332
GLU A 330
 None
 1.20A 1icvC-4btmA:
undetectable
1icvD-4btmA:
undetectable		 1icvC-4btmA:
20.00
1icvD-4btmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 5 GLU A 330
SER A 153
THR A 154
PHE A 332
 None
 1.14A 1icvC-4btmA:
undetectable
1icvD-4btmA:
undetectable		 1icvC-4btmA:
20.00
1icvD-4btmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 PHE A 150
TRP A 334
GLU A 335
 None
 1.03A 1mogA-4btmA:
0.2		 1mogA-4btmA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 228
ARG A 264
ARG A 142
 SO4  A1338 (-3.1A)
SO4  A1338 ( 3.7A)
SO4  A1338 (-3.3A)
 1.20A 2jb7A-4btmA:
undetectable
2jb7B-4btmA:
undetectable
2jb7C-4btmA:
undetectable		 2jb7A-4btmA:
18.48
2jb7B-4btmA:
18.48
2jb7C-4btmA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 LEU A 246
ASP A 245
LEU A 175
ILE A 169
 None
 1.06A 2qqdA-4btmA:
undetectable
2qqdE-4btmA:
undetectable		 2qqdA-4btmA:
9.51
2qqdE-4btmA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 PHE A 223
PHE A 184
ILE A 169
GLY A 225
 None
 1.00A 2v0mC-4btmA:
undetectable		 2v0mC-4btmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 VAL A  54
VAL A  60
TRP A  58
 None
 0.83A 3l8lA-4btmA:
undetectable
3l8lB-4btmA:
undetectable		 3l8lA-4btmA:
4.00
3l8lB-4btmA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 6 GLU A  71
PHE A 126
TYR A  73
VAL A  84
 None
 1.21A 4a97E-4btmA:
2.2		 4a97E-4btmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		6 / 12 ILE A  64
GLY A  65
ALA A  85
MET A 131
GLY A 135
LEU A 199
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
None
F8E  A1340 (-3.8A)
 0.99A 4qmzA-4btmA:
25.7		 4qmzA-4btmA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 6 CYH A 115
ASN A 183
GLU A 101
LYS A  87
 F8E  A1340 (-3.2A)
None
None
F8E  A1340 ( 4.0A)
 1.09A 4wcxC-4btmA:
undetectable		 4wcxC-4btmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		3 / 3 THR A 208
HIS A 113
LEU A 108
 None
 0.76A 5axdA-4btmA:
undetectable		 5axdA-4btmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 7 ILE A  64
GLY A  65
PHE A 117
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
None
 0.82A 5hieA-4btmA:
4.0		 5hieA-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 8 ILE A  64
GLY A  65
PHE A 117
ASN A 137
PHE A 201
 F8E  A1340 (-4.8A)
F8E  A1340 ( 4.3A)
None
F8E  A1340 ( 4.5A)
None
 0.96A 5hieD-4btmA:
19.8		 5hieD-4btmA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 10 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
 0.77A 5lw1E-4btmA:
14.2		 5lw1E-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  65
ALA A  85
LEU A 133
ASN A 137
LEU A 199
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
F8E  A1340 (-3.8A)
 0.87A 5lw1H-4btmA:
14.0		 5lw1H-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		5 / 9 GLY A  65
ALA A  85
MET A 131
LEU A 133
ASN A 137
 F8E  A1340 ( 4.3A)
F8E  A1340 (-3.5A)
F8E  A1340 (-4.2A)
F8E  A1340 (-4.4A)
F8E  A1340 ( 4.5A)
 0.67A 5lw1H-4btmA:
14.0		 5lw1H-4btmA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 8 ASP A 178
HIS A 235
HIS A 176
GLU A 255
 None
 1.09A 6mn4B-4btmA:
undetectable		 6mn4B-4btmA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4btm TAU-TUBULIN KINASE 1
(Homo
sapiens) 		4 / 8 ASP A 178
HIS A 235
HIS A 176
GLU A 255
 None
 1.06A 6mn4D-4btmA:
undetectable		 6mn4D-4btmA:
20.23