SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bug'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 VAL A 326
LEU A 348
THR A 346
LEU A 345
 None
 0.77A 1jgsA-4bugA:
undetectable		 1jgsA-4bugA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 4 LEU A 564
THR A 580
ILE A 458
HIS A 457
 None
 1.22A 2jfaB-4bugA:
1.7		 2jfaB-4bugA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		3 / 3 GLY A 617
ARG A 619
TYR A 686
 None
 0.69A 2opxA-4bugA:
undetectable		 2opxA-4bugA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		5 / 9 PRO A 388
ILE A 385
GLY A 460
ASN A 382
ARG A 296
 None
 1.30A 2pivA-4bugA:
undetectable		 2pivA-4bugA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 ALA A 553
TYR A 552
ASP A 555
HIS A 481
 None
 1.45A 2pncA-4bugA:
undetectable		 2pncA-4bugA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 6 ILE A 578
ARG A 461
THR A 562
LEU A 561
 None
 0.83A 3ag1N-4bugA:
undetectable
3ag1W-4bugA:
undetectable		 3ag1N-4bugA:
22.22
3ag1W-4bugA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 HIS A 583
GLN A 422
VAL A 424
ALA A 393
 None
 1.00A 3kp6B-4bugA:
undetectable		 3kp6B-4bugA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 8 TYR A 466
ILE A 458
GLU A 384
TYR A 298
 None
 0.91A 3rqwI-4bugA:
undetectable
3rqwJ-4bugA:
undetectable		 3rqwI-4bugA:
21.55
3rqwJ-4bugA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 PHE A 327
ASN A 349
ALA A 310
LEU A 345
 None
 1.08A 3t3sC-4bugA:
undetectable		 3t3sC-4bugA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		3 / 3 PHE A 535
TYR A 412
TYR A 408
 None
 1.09A 4ffwA-4bugA:
undetectable		 4ffwA-4bugA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 6 PRO A 569
ILE A 458
TYR A 466
PHE A 566
 None
 1.19A 4g10A-4bugA:
undetectable		 4g10A-4bugA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 6 TYR A 298
GLU A 384
TYR A 466
PHE A 566
 None
 1.48A 4twdG-4bugA:
undetectable
4twdH-4bugA:
undetectable		 4twdG-4bugA:
19.91
4twdH-4bugA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		5 / 12 LEU A 670
TYR A 674
VAL A 641
LEU A 711
LEU A 608
 None
 1.13A 4yvpB-4bugA:
undetectable		 4yvpB-4bugA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 LEU A 608
THR A 681
LEU A 711
THR A 699
 None
 0.98A 5bojB-4bugA:
6.7		 5bojB-4bugA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 4 ILE A 482
GLY A 579
ILE A 515
LEU A 564
 None
 0.90A 5dzkl-4bugA:
undetectable
5dzkz-4bugA:
undetectable		 5dzkl-4bugA:
16.74
5dzkz-4bugA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 LEU A 463
TYR A 466
GLY A 460
ALA A 459
 None
 0.79A 5f1aB-4bugA:
undetectable		 5f1aB-4bugA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 LEU A 513
TYR A 516
THR A 519
THR A 467
 None
 1.14A 5jq7B-4bugA:
undetectable		 5jq7B-4bugA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		5 / 10 LEU A 711
ILE A 657
LEU A 648
LEU A 637
LEU A 670
 None
 1.26A 5y7pB-4bugA:
undetectable		 5y7pB-4bugA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 PHE A 362
ILE A 360
ILE A 336
ALA A 310
 None
 0.88A 6b5vC-4bugA:
undetectable
6b5vD-4bugA:
undetectable		 6b5vC-4bugA:
10.07
6b5vD-4bugA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 ALA A 310
PHE A 362
ILE A 360
ILE A 336
 None
 0.88A 6b5vB-4bugA:
undetectable
6b5vD-4bugA:
undetectable		 6b5vB-4bugA:
10.07
6b5vD-4bugA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 ILE A 578
ARG A 461
THR A 562
LEU A 561
 None
 0.96A 6nmfA-4bugA:
undetectable
6nmfJ-4bugA:
undetectable		 6nmfA-4bugA:
22.22
6nmfJ-4bugA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bug ANCILLARY PROTEIN 1
(Streptococcus
pyogenes) 		4 / 7 ILE A 578
ARG A 461
THR A 562
LEU A 561
 None
 0.93A 6nmpA-4bugA:
undetectable
6nmpJ-4bugA:
undetectable		 6nmpA-4bugA:
22.22
6nmpJ-4bugA:
8.84