SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4buh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 7 ALA A 216
SER A 164
SER A 162
THR A 160
 None
 0.95A 1dvxA-4buhA:
undetectable		 1dvxA-4buhA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 7 GLN A   6
SER A   7
TYR A  94
GLN A 180
 None
 1.45A 1eiiA-4buhA:
undetectable		 1eiiA-4buhA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		6 / 12 TYR A 178
PHE A 242
TRP A  33
VAL A  37
ALA A  97
TRP A 116
 None
 0.53A 1h8sA-4buhA:
22.6		 1h8sA-4buhA:
33.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		5 / 12 ALA A  35
GLY A  49
GLU A 231
ALA A  97
LEU A  99
 None
 1.09A 1mjqC-4buhA:
undetectable
1mjqD-4buhA:
undetectable		 1mjqC-4buhA:
16.41
1mjqD-4buhA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		5 / 10 GLU A 231
ALA A  97
LEU A  99
ALA A  35
GLY A  49
 None
 1.07A 1mjqG-4buhA:
undetectable
1mjqH-4buhA:
undetectable		 1mjqG-4buhA:
16.41
1mjqH-4buhA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		5 / 12 ALA A  35
GLY A  49
GLU A 231
ALA A  97
LEU A  99
 None
 1.10A 1mjqI-4buhA:
undetectable
1mjqJ-4buhA:
undetectable		 1mjqI-4buhA:
16.41
1mjqJ-4buhA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		5 / 12 TYR A 228
LEU A 248
VAL A 250
LEU A 220
ARG A 203
 None
 1.33A 2bxfB-4buhA:
undetectable		 2bxfB-4buhA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 4 TYR A  27
THR A  78
VAL A   5
ILE A  34
 None
 1.40A 4jx1F-4buhA:
undetectable		 4jx1F-4buhA:
18.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 7 TYR A 110
TYR A 178
TYR A 191
PRO A 197
 None
None
EDO  A1254 ( 4.0A)
EDO  A1254 ( 4.5A)
 0.95A 5aclA-4buhA:
21.8		 5aclA-4buhA:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 8 TYR A 178
TRP A 233
GLY A 240
PHE A 242
 None
 0.91A 5albL-4buhA:
21.6		 5albL-4buhA:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4buh CLONE M0418 SCFV
(Homo
sapiens) 		4 / 8 TYR A 178
TRP A 233
GLY A 240
PHE A 242
 None
 0.50A 5alcL-4buhA:
22.6		 5alcL-4buhA:
26.70