SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4buj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1171
MET A1212
VAL A1215
LEU A1129
LEU A1132
 None
 1.02A 1dtlA-4bujA:
undetectable		 1dtlA-4bujA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.04A 1mt1A-4bujC:
undetectable
1mt1F-4bujC:
undetectable		 1mt1A-4bujC:
10.03
1mt1F-4bujC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 ILE C  19
LEU C 343
ASP C 385
LEU C 384
 None
 1.01A 1mt1B-4bujC:
undetectable
1mt1C-4bujC:
undetectable		 1mt1B-4bujC:
14.04
1mt1C-4bujC:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.02A 1n13I-4bujC:
undetectable
1n13L-4bujC:
undetectable		 1n13I-4bujC:
10.03
1n13L-4bujC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		5 / 12 ARG C 135
SER C 195
ILE C 194
PHE C 241
ILE C 211
 None
 1.49A 1ot7A-4bujC:
undetectable		 1ot7A-4bujC:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 141
TRP C 153
LEU C 115
PHE C 124
 None
 1.34A 1ru9H-4bujC:
undetectable
1ru9L-4bujC:
undetectable		 1ru9H-4bujC:
18.83
1ru9L-4bujC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 LEU C 141
TRP C 153
LEU C 115
PHE C 124
 None
 1.38A 1rukH-4bujC:
undetectable
1rukL-4bujC:
undetectable		 1rukH-4bujC:
18.83
1rukL-4bujC:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 824
TYR A1092
ILE A 826
LEU A 814
 None
 0.91A 1xvaA-4bujA:
4.2
1xvaB-4bujA:
2.6		 1xvaA-4bujA:
13.01
1xvaB-4bujA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1129
LEU A1149
MET A1268
 None
 0.79A 1ya3B-4bujA:
1.9		 1ya3B-4bujA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4buj ANTIVIRAL HELICASE
SKI2
ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 4 GLY C  91
SER C  88
ILE A  20
HIS C  61
 None
 1.27A 1yajJ-4bujC:
undetectable		 1yajJ-4bujC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4buj ANTIVIRAL HELICASE
SKI2
ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A  31
ASP C  35
ASP C 346
 None
 0.66A 2igtA-4bujA:
5.8		 2igtA-4bujA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4buj ANTIVIRAL HELICASE
SKI2
ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A  31
ASP C  35
ASP C 346
 None
 0.68A 2igtB-4bujA:
5.5		 2igtB-4bujA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 ILE C  19
LEU C 343
ASP C 385
LEU C 384
 None
 1.02A 2qqcB-4bujC:
undetectable
2qqcC-4bujC:
undetectable		 2qqcB-4bujC:
14.21
2qqcC-4bujC:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 0.99A 2qqcA-4bujC:
undetectable
2qqcF-4bujC:
undetectable		 2qqcA-4bujC:
9.77
2qqcF-4bujC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.01A 2qqcG-4bujC:
undetectable
2qqcJ-4bujC:
undetectable		 2qqcG-4bujC:
9.77
2qqcJ-4bujC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.01A 2qqcI-4bujC:
undetectable
2qqcL-4bujC:
undetectable		 2qqcI-4bujC:
9.77
2qqcL-4bujC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 343
ASP C 385
LEU C 384
ILE C  19
 None
 1.02A 2qqdA-4bujC:
undetectable
2qqdE-4bujC:
undetectable		 2qqdA-4bujC:
9.77
2qqdE-4bujC:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 434
ILE A 376
ALA A 383
ILE A 381
 None
 0.86A 2xkwA-4bujA:
undetectable		 2xkwA-4bujA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 VAL C 192
HIS C  67
THR C 144
TRP C 153
 None
 1.10A 3arrA-4bujC:
undetectable		 3arrA-4bujC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 ASP C 193
LEU C 214
LEU C  71
HIS C 139
 None
 1.23A 3bj8C-4bujC:
undetectable
3bj8D-4bujC:
undetectable		 3bj8C-4bujC:
19.49
3bj8D-4bujC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 404
GLY A 402
ILE A 401
VAL A 438
ILE A 376
 None
 1.16A 3ekyB-4bujA:
undetectable		 3ekyB-4bujA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.36A 3fhjA-4bujA:
undetectable		 3fhjA-4bujA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.34A 3fhjB-4bujA:
undetectable		 3fhjB-4bujA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.34A 3fhjC-4bujA:
undetectable		 3fhjC-4bujA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.35A 3fhjE-4bujA:
undetectable		 3fhjE-4bujA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.32A 3fi0A-4bujA:
undetectable		 3fi0A-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.31A 3fi0C-4bujA:
undetectable		 3fi0C-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.43A 3fi0F-4bujA:
undetectable		 3fi0F-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.33A 3fi0H-4bujA:
undetectable		 3fi0H-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.37A 3fi0L-4bujA:
undetectable		 3fi0L-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.32A 3fi0M-4bujA:
undetectable		 3fi0M-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.33A 3fi0N-4bujA:
undetectable		 3fi0N-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 762
GLN A 759
ILE A 510
VAL A 775
VAL A 736
 None
 1.49A 3fi0R-4bujA:
undetectable		 3fi0R-4bujA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 4 ASP C  42
SER C  27
PHE C  28
SER C  57
 None
 1.27A 3i5uA-4bujC:
0.0		 3i5uA-4bujC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 236
ALA C 189
SER C 212
ILE C 211
LEU C 248
 None
 1.24A 3ia4B-4bujC:
undetectable		 3ia4B-4bujC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 236
ALA C 189
SER C 212
ILE C 211
LEU C 248
 None
 1.21A 3ia4D-4bujC:
undetectable		 3ia4D-4bujC:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 PHE C 362
CYH C 307
THR C 327
PHE C   5
 None
 1.37A 3ltwA-4bujC:
3.3		 3ltwA-4bujC:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 642
LEU A 706
LYS A 704
 None
None
SO4  A2004 ( 3.7A)
 0.73A 3sueD-4bujA:
undetectable		 3sueD-4bujA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 4 ASN C 222
SER C 195
LEU C 199
THR C 208
 None
 1.30A 4an2A-4bujC:
undetectable		 4an2A-4bujC:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 396
PHE A 392
ALA A 364
LEU A 474
 None
 0.89A 4ejgC-4bujA:
undetectable		 4ejgC-4bujA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 PHE A1189
TYR A1125
TYR A1182
 None
 0.87A 4ffwA-4bujA:
undetectable		 4ffwA-4bujA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 533
ILE A 519
PRO A 520
PHE A 789
 None
 1.21A 4fgkA-4bujA:
undetectable		 4fgkA-4bujA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 6 MET C 119
ILE C 194
ILE C 200
VAL C 192
 None
 0.98A 4olmA-4bujC:
undetectable		 4olmA-4bujC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_2
(NUPC FAMILY PROTEIN)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		3 / 3 THR C 261
ASN C 206
PHE C 204
 None
 0.74A 4pd9A-4bujC:
undetectable		 4pd9A-4bujC:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 8 ILE C 271
GLU C 266
GLY C 268
SER C 195
 None
 0.86A 4r20A-4bujC:
undetectable		 4r20A-4bujC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1150
LEU A1171
ALA A1219
VAL A1215
ILE A1275
 None
 1.06A 4x20D-4bujA:
undetectable		 4x20D-4bujA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A1209
ILE A1181
PHE A1137
LEU A1138
PHE A1153
 None
 1.25A 5b8iC-4bujA:
undetectable		 5b8iC-4bujA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		5 / 12 ILE C 236
ALA C 189
SER C 212
ILE C 211
LEU C 248
 None
 1.10A 5hi6B-4bujC:
undetectable		 5hi6B-4bujC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1252
LEU A1264
GLU A1251
LEU A1150
 None
 0.57A 5jq7A-4bujA:
undetectable		 5jq7A-4bujA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		4 / 7 ARG C 140
PHE C 155
LEU C 114
SER C 170
 None
 1.14A 5uxcA-4bujC:
2.1		 5uxcA-4bujC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 199
GLY C 130
SER C 212
ILE C 211
VAL C 192
 None
 0.82A 5wyqA-4bujC:
undetectable		 5wyqA-4bujC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 425
ARG A 805
ARG A 454
 None
 1.03A 6bplA-4bujA:
2.2
6bplB-4bujA:
3.4		 6bplA-4bujA:
6.58
6bplB-4bujA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4buj ANTIVIRAL HELICASE
SKI2
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 709
LEU A 688
HIS A 695
ALA A 693
 None
 0.98A 6ck2C-4bujA:
undetectable
6ck2D-4bujA:
undetectable		 6ck2C-4bujA:
2.74
6ck2D-4bujA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4buj ANTIVIRAL PROTEIN
SKI8
(Saccharomyces
cerevisiae) 		3 / 3 ASP C  69
SER C 296
SER C 238
 None
 0.82A 6mxtA-4bujC:
undetectable		 6mxtA-4bujC:
21.09