SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		3 / 3 LYS X  42
ASP X 100
ASP X 128
 None
 1.17A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		3 / 3 LYS X 256
ASP X  16
ASP X   9
 None
 1.02A 2br4A-4bumX:
undetectable		 2br4A-4bumX:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		3 / 3 THR X  70
LYS X  12
GLU X  84
 None
 0.87A 3ijdB-4bumX:
undetectable		 3ijdB-4bumX:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		3 / 3 ARG X 218
ASP X 186
GLN X 166
 None
 0.89A 4azsA-4bumX:
undetectable		 4azsA-4bumX:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		5 / 10 GLY X 145
VAL X 144
VAL X 123
LEU X  10
LEU X 125
 None
 1.14A 4yb6B-4bumX:
undetectable
4yb6C-4bumX:
undetectable		 4yb6B-4bumX:
22.39
4yb6C-4bumX:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		5 / 10 GLY X 145
VAL X 144
VAL X 123
LEU X  10
LEU X 125
 None
 1.17A 4yb6C-4bumX:
undetectable
4yb6F-4bumX:
undetectable		 4yb6C-4bumX:
22.39
4yb6F-4bumX:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4bum VOLTAGE-DEPENDENT
ANION CHANNEL 2
(Danio
rerio) 		5 / 10 LEU X  10
LEU X 125
GLY X 145
VAL X 144
VAL X 123
 None
 1.13A 4yb6B-4bumX:
undetectable
4yb6F-4bumX:
undetectable		 4yb6B-4bumX:
22.39
4yb6F-4bumX:
22.39