SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4buo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 6 TYR A 146
ASN A 355
ARG A 327
TYR A 324
 None
 1.44A 1nbhA-4buoA:
undetectable		 1nbhA-4buoA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 TYR A 146
ASN A 355
ARG A 327
TYR A 324
 None
 1.44A 1nbhB-4buoA:
undetectable		 1nbhB-4buoA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 6 TYR A 146
ASN A 355
ARG A 327
TYR A 324
 None
 1.44A 1nbhC-4buoA:
undetectable		 1nbhC-4buoA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 TYR A 146
ASN A 355
ARG A 327
TYR A 324
 None
 1.43A 1nbhD-4buoA:
undetectable		 1nbhD-4buoA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 ASN A 365
LEU A 109
ASP A 113
SER A 361
 None
 1.12A 3lslA-4buoA:
undetectable
3lslD-4buoA:
undetectable		 3lslA-4buoA:
21.70
3lslD-4buoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 SER A 361
ASN A 365
LEU A 109
ASP A 113
 None
 1.06A 3lslA-4buoA:
undetectable
3lslD-4buoA:
undetectable		 3lslA-4buoA:
21.70
3lslD-4buoA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		5 / 12 TYR A 126
ILE A 116
TYR A 145
TYR A 359
GLU A 124
 None
 1.39A 3q5pA-4buoA:
undetectable		 3q5pA-4buoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		5 / 11 TYR A 126
ILE A 116
TYR A 145
TYR A 359
GLU A 124
 None
 1.29A 3q5rA-4buoA:
undetectable		 3q5rA-4buoA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 8 HIS A 348
TYR A 347
PHE A 331
TYR A 146
 None
 1.33A 5v4vB-4buoA:
undetectable		 5v4vB-4buoA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 VAL A 160
ILE A 364
SER A 112
THR A 156
 None
 1.03A 5vkqA-4buoA:
2.6
5vkqD-4buoA:
2.6		 5vkqA-4buoA:
11.86
5vkqD-4buoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 SER A 112
THR A 156
PHE A 317
VAL A 160
 None
 1.20A 5vkqA-4buoA:
2.6
5vkqB-4buoA:
2.6		 5vkqA-4buoA:
11.86
5vkqB-4buoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 SER A 112
THR A 156
VAL A 160
ILE A 364
 None
 1.03A 5vkqA-4buoA:
2.6
5vkqB-4buoA:
2.6		 5vkqA-4buoA:
11.86
5vkqB-4buoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 8 SER A 112
THR A 156
VAL A 160
ILE A 364
 None
 0.99A 5vkqB-4buoA:
2.6
5vkqC-4buoA:
2.6		 5vkqB-4buoA:
11.86
5vkqC-4buoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 SER A 112
THR A 156
PHE A 317
VAL A 160
 None
 1.18A 5vkqC-4buoA:
2.6
5vkqD-4buoA:
2.6		 5vkqC-4buoA:
11.86
5vkqD-4buoA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4buo NEUROTENSIN RECEPTOR
TYPE 1
(Rattus
norvegicus) 		4 / 7 SER A 112
THR A 156
VAL A 160
ILE A 364
 None
 1.01A 5vkqC-4buoA:
2.6
5vkqD-4buoA:
2.6		 5vkqC-4buoA:
11.86
5vkqD-4buoA:
11.86