SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bv4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 11 LEU R 295
LEU R 324
VAL R 298
LEU R 314
GLN R 318
 None
 1.36A 1kt7A-4bv4R:
undetectable		 1kt7A-4bv4R:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 THR R 113
GLY R 111
HIS R 145
ILE R  77
LEU R  67
 None
 1.21A 1r30B-4bv4R:
undetectable		 1r30B-4bv4R:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 4 SER R 206
ASP R 251
ARG R 299
ASP R 273
 None
 1.48A 2bm9C-4bv4R:
0.0		 2bm9C-4bv4R:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS R 145
ASP R  83
THR R  84
TYR R  87
 None
 1.41A 2eimA-4bv4R:
undetectable
2eimC-4bv4R:
undetectable		 2eimA-4bv4R:
21.78
2eimC-4bv4R:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 HIS R 145
ASP R  83
THR R  84
TYR R  87
 None
 1.40A 2einN-4bv4R:
undetectable
2einP-4bv4R:
undetectable		 2einN-4bv4R:
21.78
2einP-4bv4R:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 6 PRO R 221
MET R 220
ASP R 172
ASP R 195
 None
 1.33A 2lh8A-4bv4R:
undetectable		 2lh8A-4bv4R:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 10 PHE R 241
LEU R 268
GLY R 249
LEU R 226
PHE R 265
 None
 1.28A 2ok6A-4bv4R:
0.5
2ok6H-4bv4R:
undetectable		 2ok6A-4bv4R:
21.16
2ok6H-4bv4R:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS R 145
ASP R  83
THR R  84
TYR R  87
 None
 1.48A 3ag2N-4bv4R:
undetectable
3ag2P-4bv4R:
undetectable		 3ag2N-4bv4R:
21.78
3ag2P-4bv4R:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 HIS R 145
ASP R  83
THR R  84
TYR R  87
 None
 1.46A 3ag4N-4bv4R:
undetectable
3ag4P-4bv4R:
undetectable		 3ag4N-4bv4R:
21.78
3ag4P-4bv4R:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 9 ILE R 250
GLY R 249
SER R 277
LEU R 276
GLU R 297
 None
 1.02A 3ai9X-4bv4R:
undetectable		 3ai9X-4bv4R:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 PHE R 193
LEU R 199
MET R 220
ILE R 185
SER R 177
 None
 1.29A 3aqiB-4bv4R:
undetectable		 3aqiB-4bv4R:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 10 ASP R 273
VAL R 271
ILE R 274
ALA R 244
VAL R 247
 None
 0.95A 3t3cB-4bv4R:
undetectable		 3t3cB-4bv4R:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 9 GLY R  97
ASP R  73
GLY R  30
LEU R  67
VAL R  75
 None
 1.00A 3u7sB-4bv4R:
undetectable		 3u7sB-4bv4R:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 PHE R 193
LEU R 199
MET R 220
ILE R 185
SER R 177
 None
 1.29A 3w1wA-4bv4R:
undetectable		 3w1wA-4bv4R:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 PHE R 155
ALA R 183
THR R 163
LEU R 169
 None
 1.08A 4ejgA-4bv4R:
undetectable		 4ejgA-4bv4R:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 8 TYR R  52
VAL R  75
ILE R  96
ALA R  33
 None
 0.99A 4eyzA-4bv4R:
undetectable		 4eyzA-4bv4R:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 8 TYR R  52
VAL R  75
ILE R  96
ALA R  33
 None
 0.98A 4eyzB-4bv4R:
undetectable		 4eyzB-4bv4R:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 11 GLY R 449
TRP R 420
ALA R 398
LEU R 421
ALA R 359
 None
 1.21A 4l6v1-4bv4R:
undetectable
4l6v6-4bv4R:
undetectable		 4l6v1-4bv4R:
21.25
4l6v6-4bv4R:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 11 VAL R 405
LEU R 402
LEU R 440
LEU R 421
ALA R 451
 None
 1.14A 4p65B-4bv4R:
undetectable
4p65D-4bv4R:
undetectable
4p65G-4bv4R:
undetectable
4p65H-4bv4R:
undetectable		 4p65B-4bv4R:
6.02
4p65D-4bv4R:
6.02
4p65G-4bv4R:
5.31
4p65H-4bv4R:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 VAL R 405
LEU R 402
LEU R 440
LEU R 421
ALA R 451
 None
 1.04A 4p65F-4bv4R:
undetectable
4p65H-4bv4R:
undetectable
4p65K-4bv4R:
undetectable
4p65L-4bv4R:
undetectable		 4p65F-4bv4R:
6.02
4p65H-4bv4R:
6.02
4p65K-4bv4R:
5.31
4p65L-4bv4R:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 11 LEU R 440
LEU R 373
LEU R 392
LEU R 416
LEU R 371
 None
 1.03A 4zowA-4bv4R:
undetectable		 4zowA-4bv4R:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		3 / 3 ALA R 328
ASN R 352
LEU R 353
 None
 0.51A 5i1oA-4bv4R:
undetectable		 5i1oA-4bv4R:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		3 / 3 MET R 212
GLN R 211
ARG R 214
 None
 1.04A 5m36A-4bv4R:
undetectable		 5m36A-4bv4R:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		6 / 12 ILE R 257
VAL R 264
ILE R 216
ILE R 250
VAL R 247
LEU R 226
 None
 1.42A 5mueA-4bv4R:
undetectable		 5mueA-4bv4R:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 4 SER R 384
ALA R 387
GLN R 365
THR R 389
 None
 1.50A 5n0wA-4bv4R:
undetectable		 5n0wA-4bv4R:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		4 / 7 TYR R 121
CSS R  56
CSS R  43
LEU R  67
 None
 1.34A 6cnkB-4bv4R:
undetectable
6cnkC-4bv4R:
undetectable		 6cnkB-4bv4R:
9.71
6cnkC-4bv4R:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 12 SER R 348
LEU R 402
ASN R 400
ASP R 372
PHE R 386
 None
 1.36A 6dwnB-4bv4R:
undetectable		 6dwnB-4bv4R:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		5 / 10 PHE R 193
LEU R 196
GLY R 218
ILE R 216
ILE R 202
 None
 1.12A 6ebpD-4bv4R:
undetectable		 6ebpD-4bv4R:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4bv4 PROTEIN TOLL,
VARIABLE LYMPHOCYTE
RECEPTOR B CHIMERA
(Drosophila
melanogaster;
Eptatretus
burgeri) 		3 / 3 MET R 212
GLN R 211
ARG R 214
 None
 1.06A 6fnbA-4bv4R:
undetectable		 6fnbA-4bv4R:
18.37