SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 1c9sB-4bv6A:
undetectable
1c9sC-4bv6A:
undetectable		 1c9sB-4bv6A:
9.71
1c9sC-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.31A 1c9sG-4bv6A:
undetectable
1c9sH-4bv6A:
undetectable		 1c9sG-4bv6A:
9.71
1c9sH-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 1gtfC-4bv6A:
undetectable
1gtfD-4bv6A:
undetectable		 1gtfC-4bv6A:
9.71
1gtfD-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.29A 1gtfG-4bv6A:
undetectable
1gtfH-4bv6A:
undetectable		 1gtfG-4bv6A:
9.71
1gtfH-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.30A 1gtfH-4bv6A:
undetectable
1gtfI-4bv6A:
undetectable		 1gtfH-4bv6A:
9.71
1gtfI-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 462
HIS A 457
ALA A 259
HIS A 455
ARG A 172
 None
None
FAD  A1449 (-4.9A)
None
FAD  A1449 (-3.9A)
 1.26A 1gtfU-4bv6A:
undetectable
1gtfV-4bv6A:
undetectable		 1gtfU-4bv6A:
9.71
1gtfV-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY A 341
GLY A 312
PHE A 310
SER A 313
GLY A 307
 None
None
GOL  A1611 (-4.8A)
None
None
 1.09A 1l4nA-4bv6A:
undetectable		 1l4nA-4bv6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 575
ILE A 576
PRO A 345
ILE A 343
 None
 0.72A 1n49D-4bv6A:
undetectable		 1n49D-4bv6A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A 462
HIS A 457
ALA A 259
HIS A 455
ARG A 172
 None
None
FAD  A1449 (-4.9A)
None
FAD  A1449 (-3.9A)
 1.30A 1utdM-4bv6A:
undetectable
1utdN-4bv6A:
undetectable		 1utdM-4bv6A:
9.71
1utdN-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 293
LEU A 175
SER A 176
LEU A 311
 None
FAD  A1449 ( 4.7A)
FAD  A1449 (-3.6A)
FAD  A1449 ( 4.7A)
 1.13A 1ya3A-4bv6A:
undetectable		 1ya3A-4bv6A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 140
THR A 141
ALA A 142
ALA A 143
 FAD  A1449 (-3.4A)
FAD  A1449 (-4.2A)
FAD  A1449 (-3.3A)
None
 0.45A 2ej3A-4bv6A:
undetectable		 2ej3A-4bv6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLY A 261
GLY A 140
THR A 141
ALA A 142
 FAD  A1449 (-3.4A)
FAD  A1449 (-3.4A)
FAD  A1449 (-4.2A)
FAD  A1449 (-3.3A)
 0.59A 2ej3A-4bv6A:
undetectable		 2ej3A-4bv6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 GLY A 307
GLY A 308
VAL A 369
LEU A 267
 None
 0.62A 2oa1B-4bv6A:
10.2		 2oa1B-4bv6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 423
LEU A 136
GLY A 466
ALA A 146
 None
 0.90A 2xfsA-4bv6A:
undetectable		 2xfsA-4bv6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL A 423
LEU A 136
GLY A 466
ALA A 146
 None
 0.91A 2xh9A-4bv6A:
undetectable		 2xh9A-4bv6A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO A 174
LEU A 179
ARG A 291
 None
 0.62A 3aqiB-4bv6A:
undetectable		 3aqiB-4bv6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE A 587
ILE A 591
VAL A 604
LEU A 607
 None
 0.66A 3r9vA-4bv6A:
undetectable
3r9vB-4bv6A:
undetectable		 3r9vA-4bv6A:
19.88
3r9vB-4bv6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 260
GLY A 262
PRO A 402
ASN A 403
 FAD  A1449 (-4.1A)
None
None
FAD  A1449 ( 4.5A)
 0.82A 3tajA-4bv6A:
undetectable		 3tajA-4bv6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 THR A 260
GLY A 262
PRO A 402
ASN A 403
 FAD  A1449 (-4.1A)
None
None
FAD  A1449 ( 4.5A)
 0.83A 3u8qA-4bv6A:
undetectable		 3u8qA-4bv6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 315
ILE A 305
GLY A 308
ASN A 339
ILE A 306
 None
 0.95A 3uwlB-4bv6A:
undetectable		 3uwlB-4bv6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLY A 288
LEU A 175
TYR A 170
GLU A 167
 None
FAD  A1449 ( 4.7A)
None
None
 1.16A 3w9tE-4bv6A:
undetectable		 3w9tE-4bv6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ASN A 583
GLU A 533
ARG A 529
 None
 0.99A 3wxoA-4bv6A:
undetectable		 3wxoA-4bv6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 138
GLY A 261
LEU A 228
GLY A 230
PRO A 169
 FAD  A1449 (-3.1A)
FAD  A1449 (-3.4A)
None
None
None
 1.10A 4blvA-4bv6A:
undetectable		 4blvA-4bv6A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 THR A 260
GLY A 262
PRO A 402
ASN A 403
 FAD  A1449 (-4.1A)
None
None
FAD  A1449 ( 4.5A)
 0.83A 4fjpA-4bv6A:
undetectable		 4fjpA-4bv6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR A 260
GLY A 262
PRO A 402
ASN A 403
 FAD  A1449 (-4.1A)
None
None
FAD  A1449 ( 4.5A)
 0.84A 4forA-4bv6A:
undetectable		 4forA-4bv6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 502
LEU A 568
ILE A 592
GLY A 496
LEU A 447
 None
 1.03A 4xi3B-4bv6A:
undetectable		 4xi3B-4bv6A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLY A 462
ARG A 463
GLY A 466
GLU A 467
 None
 0.95A 4z2eB-4bv6A:
undetectable
4z2eC-4bv6A:
undetectable		 4z2eB-4bv6A:
22.28
4z2eC-4bv6A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 PHE A 134
ALA A 147
MET A 469
LEU A 160
 None
 1.21A 5dzkB-4bv6A:
undetectable
5dzkP-4bv6A:
undetectable		 5dzkB-4bv6A:
18.74
5dzkP-4bv6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eeuD-4bv6A:
undetectable
5eeuE-4bv6A:
undetectable		 5eeuD-4bv6A:
9.71
5eeuE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eeuH-4bv6A:
undetectable
5eeuI-4bv6A:
undetectable		 5eeuH-4bv6A:
9.71
5eeuI-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eeuJ-4bv6A:
undetectable
5eeuK-4bv6A:
undetectable		 5eeuJ-4bv6A:
9.71
5eeuK-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eevD-4bv6A:
undetectable
5eevE-4bv6A:
undetectable		 5eevD-4bv6A:
9.71
5eevE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eevJ-4bv6A:
undetectable
5eevK-4bv6A:
undetectable		 5eevJ-4bv6A:
9.71
5eevK-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eewD-4bv6A:
undetectable
5eewE-4bv6A:
undetectable		 5eewD-4bv6A:
9.71
5eewE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eewH-4bv6A:
undetectable
5eewI-4bv6A:
undetectable		 5eewH-4bv6A:
9.71
5eewI-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eewJ-4bv6A:
undetectable
5eewK-4bv6A:
undetectable		 5eewJ-4bv6A:
9.71
5eewK-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eexD-4bv6A:
undetectable
5eexE-4bv6A:
undetectable		 5eexD-4bv6A:
9.71
5eexE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.31A 5eexH-4bv6A:
undetectable
5eexI-4bv6A:
undetectable		 5eexH-4bv6A:
9.71
5eexI-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eexI-4bv6A:
undetectable
5eexJ-4bv6A:
undetectable		 5eexI-4bv6A:
9.71
5eexJ-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eexJ-4bv6A:
undetectable
5eexK-4bv6A:
undetectable		 5eexJ-4bv6A:
9.71
5eexK-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eeyD-4bv6A:
undetectable
5eeyE-4bv6A:
undetectable		 5eeyD-4bv6A:
9.71
5eeyE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eeyI-4bv6A:
undetectable
5eeyJ-4bv6A:
undetectable		 5eeyI-4bv6A:
9.71
5eeyJ-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.32A 5eeyJ-4bv6A:
undetectable
5eeyK-4bv6A:
undetectable		 5eeyJ-4bv6A:
9.71
5eeyK-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.27A 5eezD-4bv6A:
undetectable
5eezE-4bv6A:
undetectable		 5eezD-4bv6A:
9.71
5eezE-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5eezI-4bv6A:
undetectable
5eezJ-4bv6A:
undetectable		 5eezI-4bv6A:
9.71
5eezJ-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.27A 5ef0D-4bv6A:
undetectable
5ef0E-4bv6A:
undetectable		 5ef0D-4bv6A:
9.71
5ef0E-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5ef0I-4bv6A:
undetectable
5ef0J-4bv6A:
undetectable		 5ef0I-4bv6A:
9.71
5ef0J-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.27A 5ef1D-4bv6A:
undetectable
5ef1E-4bv6A:
undetectable		 5ef1D-4bv6A:
9.71
5ef1E-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5ef1I-4bv6A:
undetectable
5ef1J-4bv6A:
undetectable		 5ef1I-4bv6A:
9.71
5ef1J-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.27A 5ef2D-4bv6A:
undetectable
5ef2E-4bv6A:
undetectable		 5ef2D-4bv6A:
9.71
5ef2E-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5ef2I-4bv6A:
undetectable
5ef2J-4bv6A:
undetectable		 5ef2I-4bv6A:
9.71
5ef2J-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.27A 5ef3D-4bv6A:
undetectable
5ef3E-4bv6A:
undetectable		 5ef3D-4bv6A:
9.71
5ef3E-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 ARG A 172
GLY A 462
HIS A 457
ALA A 259
HIS A 455
 FAD  A1449 (-3.9A)
None
None
FAD  A1449 (-4.9A)
None
 1.28A 5ef3I-4bv6A:
undetectable
5ef3J-4bv6A:
undetectable		 5ef3I-4bv6A:
9.71
5ef3J-4bv6A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL A 277
GLU A 276
GLY A 373
LEU A 379
 None
 1.10A 5g5gC-4bv6A:
undetectable		 5g5gC-4bv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 356
LEU A 319
ALA A 316
SER A 313
LEU A 333
 None
 1.26A 5nd4B-4bv6A:
undetectable		 5nd4B-4bv6A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 431
ALA A 429
VAL A 423
 None
 0.49A 5xiwC-4bv6A:
1.9		 5xiwC-4bv6A:
11.47