SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		3 / 3 ALA A 295
VAL A 244
TRP A 287
 None
 0.88A 1av2C-4bvlA:
undetectable
1av2D-4bvlA:
undetectable		 1av2C-4bvlA:
4.98
1av2D-4bvlA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		4 / 8 GLY A  29
GLY A  30
HIS A 135
VAL A  10
 None
 0.83A 1dbbH-4bvlA:
undetectable
1dbbL-4bvlA:
undetectable		 1dbbH-4bvlA:
21.76
1dbbL-4bvlA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_C_SAMC303_0
(HEMK PROTEIN)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 12 ILE A 316
GLY A 337
ALA A 276
GLU A 333
ASN A 312
 None
 1.06A 1sg9C-4bvlA:
undetectable		 1sg9C-4bvlA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		3 / 3 ALA A 295
VAL A 244
TRP A 287
 None
 0.83A 1w5uC-4bvlA:
undetectable
1w5uD-4bvlA:
undetectable		 1w5uC-4bvlA:
4.98
1w5uD-4bvlA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 12 LYS A   1
GLY A  34
TYR A  18
ASP A  84
ALA A  38
 None
 1.15A 2br4E-4bvlA:
2.8		 2br4E-4bvlA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 8 GLY A 138
HIS A 135
ILE A 165
ASN A 160
HIS A 306
 None
 1.26A 2x0pA-4bvlA:
undetectable		 2x0pA-4bvlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		4 / 5 TYR A  82
MET A 320
ILE A 159
HIS A 135
 None
 1.24A 3eteB-4bvlA:
undetectable
3eteC-4bvlA:
undetectable		 3eteB-4bvlA:
23.12
3eteC-4bvlA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		3 / 3 ALA A 295
VAL A 244
TRP A 287
 None
 0.82A 3l8lC-4bvlA:
undetectable
3l8lD-4bvlA:
undetectable		 3l8lC-4bvlA:
4.98
3l8lD-4bvlA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 9 ALA A  53
ILE A  54
THR A 116
PHE A 117
PRO A  24
 None
 1.47A 3qelD-4bvlA:
2.8		 3qelD-4bvlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		4 / 6 PHE A 307
ALA A 101
THR A 183
LEU A 168
 None
 1.03A 4ejgD-4bvlA:
undetectable		 4ejgD-4bvlA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 12 GLY A 163
GLY A 164
ALA A 258
ILE A 272
ASN A 273
 None
 0.74A 4rtmA-4bvlA:
undetectable		 4rtmA-4bvlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		4 / 7 PHE A 197
SER A 170
TRP A 287
ALA A 181
 None
 0.99A 4xk8A-4bvlA:
undetectable		 4xk8A-4bvlA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 8 ALA A 276
VAL A  63
GLY A 275
ALA A 238
GLY A 305
 None
 1.14A 4zjzA-4bvlA:
4.1		 4zjzA-4bvlA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		3 / 3 MET A 221
HIS A 106
GLY A 163
 None
 0.81A 5gwzB-4bvlA:
undetectable		 5gwzB-4bvlA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		3 / 3 MET A 221
HIS A 106
GLY A 167
 None
 0.88A 5gwzB-4bvlA:
undetectable		 5gwzB-4bvlA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		5 / 12 VAL A 268
PHE A 233
PHE A 261
PHE A  45
ILE A  44
 None
 1.42A 6becA-4bvlA:
undetectable
6becB-4bvlA:
undetectable
6becC-4bvlA:
undetectable		 6becA-4bvlA:
20.31
6becB-4bvlA:
20.31
6becC-4bvlA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bvl PHB DEPOLYMERASE
PHAZ7
(Paucimonas
lemoignei) 		4 / 8 TYR A  92
ILE A 114
ALA A 134
VAL A 133
 None
 1.01A 6hu9a-4bvlA:
undetectable
6hu9e-4bvlA:
undetectable		 6hu9a-4bvlA:
20.73
6hu9e-4bvlA:
15.66