SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		3 / 3 ALA A  55
THR A  41
PHE A  80
 None
 0.66A 2c6nB-4bvtA:
undetectable		 2c6nB-4bvtA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 8 ARG A 194
HIS A 348
GLN A 349
THR A 183
 BR8  A1365 (-3.8A)
None
None
None
 1.30A 2vxaF-4bvtA:
0.8
2vxaG-4bvtA:
0.8
2vxaI-4bvtA:
0.8		 2vxaF-4bvtA:
11.17
2vxaG-4bvtA:
11.17
2vxaI-4bvtA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 7 GLY A 338
ILE A 331
THR A 327
LEU A  90
 None
 0.89A 2xrhA-4bvtA:
0.0		 2xrhA-4bvtA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 8 SER A 230
ALA A 296
ILE A 331
THR A 327
 None
 0.88A 3bpxA-4bvtA:
undetectable
3bpxB-4bvtA:
undetectable		 3bpxA-4bvtA:
18.58
3bpxB-4bvtA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		3 / 3 GLU A  42
HIS A  93
HIS A  94
 None
 0.82A 3co4A-4bvtA:
undetectable		 3co4A-4bvtA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 12 SER A 193
ILE A 128
LEU A 166
LYS A 170
LEU A 237
 None
 1.28A 3cs8A-4bvtA:
undetectable		 3cs8A-4bvtA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		3 / 3 ILE A  34
PHE A  80
HIS A  66
 None
 0.71A 3h0aA-4bvtA:
undetectable		 3h0aA-4bvtA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 10 ILE A 245
ILE A 150
SER A 152
LEU A 228
HIS A 259
 None
 1.26A 3o1cA-4bvtA:
undetectable		 3o1cA-4bvtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 10 ILE A 257
ILE A 150
SER A 152
LEU A 228
HIS A 259
 None
 1.22A 3o1cA-4bvtA:
undetectable		 3o1cA-4bvtA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 7 VAL A 292
ARG A   8
ILE A 289
ASN A 291
 None
 1.12A 4a97E-4bvtA:
undetectable		 4a97E-4bvtA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 12 HIS A 157
ILE A 150
GLY A 116
VAL A 141
ALA A 140
 None
 1.20A 4fqsA-4bvtA:
undetectable		 4fqsA-4bvtA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 12 HIS A 157
ILE A 150
GLY A 116
VAL A 141
ALA A 140
 None
 1.19A 4fqsB-4bvtA:
undetectable		 4fqsB-4bvtA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 12 LEU A  67
ALA A  79
LEU A  20
LEU A  23
GLY A  27
 None
 1.03A 4l9qB-4bvtA:
undetectable		 4l9qB-4bvtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 5 VAL A  37
LEU A  63
VAL A  74
PHE A  80
 None
 0.98A 4lb0B-4bvtA:
undetectable		 4lb0B-4bvtA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 7 GLU A 207
SER A 226
ILE A 201
VAL A 159
 None
 1.11A 4tvtA-4bvtA:
undetectable		 4tvtA-4bvtA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		4 / 6 TYR A 192
PRO A 125
LEU A 124
LEU A 166
 None
 1.17A 5tl8A-4bvtA:
undetectable		 5tl8A-4bvtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 4bvt CYANURIC ACID
AMIDOHYDROLASE
(Pseudomonas
sp.
ADP) 		5 / 12 PHE A 293
ILE A 257
THR A 274
GLU A 207
GLY A 355
 None
None
None
None
MG  A1364 ( 4.6A)
 0.92A 5veuH-4bvtA:
undetectable		 5veuH-4bvtA:
21.02