SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bvu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		5 / 12 PHE A  79
PHE A 158
LEU A 129
GLY A 103
LEU A 153
 None
 1.06A 4kykA-4bvuA:
undetectable
4kykB-4bvuA:
undetectable		 4kykA-4bvuA:
18.69
4kykB-4bvuA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.85A 4wg0C-4bvuA:
undetectable
4wg0D-4bvuA:
undetectable
4wg0E-4bvuA:
undetectable		 4wg0C-4bvuA:
5.94
4wg0D-4bvuA:
5.94
4wg0E-4bvuA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		5 / 11 LEU A 125
TYR A 122
GLU A 131
LEU A 129
LEU A 139
 None
 0.84A 4wg0E-4bvuA:
undetectable
4wg0F-4bvuA:
undetectable
4wg0G-4bvuA:
undetectable		 4wg0E-4bvuA:
5.94
4wg0F-4bvuA:
5.94
4wg0G-4bvuA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		4 / 6 ALA A  84
LEU A  99
MET A  98
LEU A  96
 None
 1.26A 4xp3A-4bvuA:
7.8		 4xp3A-4bvuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		3 / 3 SER A 152
LEU A 139
MET A 144
 None
 0.72A 5ikrB-4bvuA:
undetectable		 5ikrB-4bvuA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		4 / 7 GLY A  34
GLY A  36
SER A  37
LYS A  53
 None
 0.38A 5izjA-4bvuA:
8.3		 5izjA-4bvuA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 4bvu PROTEIN KINASE OSPG
(Shigella
flexneri) 		4 / 7 GLY A  34
GLY A  36
SER A  37
LYS A  53
 None
 0.39A 5j5xA-4bvuA:
9.3		 5j5xA-4bvuA:
20.36