SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		5 / 12 THR B 114
GLU B  67
LEU B 102
GLY B 110
MET B  70
 None
 1.45A 1d4fD-4bvxB:
undetectable		 1d4fD-4bvxB:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 121
VAL A 117
VAL A 195
LEU A  96
LEU A 100
 None
 1.33A 1mx1E-4bvxA:
undetectable		 1mx1E-4bvxA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 TRP A  84
ILE A 124
LEU A  80
TRP A 172
 None
 1.47A 1q0yH-4bvxA:
undetectable
1q0yL-4bvxA:
undetectable		 1q0yH-4bvxA:
20.44
1q0yL-4bvxA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A   2
SER B 100
TYR B 101
 I3C  A1204 (-3.1A)
None
None
 0.61A 1x70A-4bvxA:
undetectable		 1x70A-4bvxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 ALA A  64
ALA B  69
GLN B  72
VAL A  40
LEU A  53
 None
 1.06A 1xiuB-4bvxA:
undetectable		 1xiuB-4bvxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		5 / 12 TYR B  59
SER B  63
LEU B  10
LEU B  14
ILE B 155
 None
 1.03A 2bxcA-4bvxB:
1.8		 2bxcA-4bvxB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		4 / 7 TYR B 152
GLU B  67
TYR B  59
GLY B  62
 None
 1.17A 2ha4B-4bvxB:
undetectable		 2ha4B-4bvxB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 THR A  32
VAL A   5
VAL A   9
ALA A 185
 None
 1.18A 2ij7C-4bvxA:
undetectable		 2ij7C-4bvxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 THR A  81
ALA A 144
LEU A 143
SER A  63
ARG A  67
 None
 1.34A 3kp6B-4bvxA:
undetectable		 3kp6B-4bvxA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		6 / 12 LEU B  61
VAL B  71
LEU B  10
THR B 114
ILE B 118
ALA B  48
 None
 1.27A 3mdvB-4bvxB:
undetectable		 3mdvB-4bvxB:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 GLY A  24
ILE A  30
GLY A  20
ALA A  22
PHE A  69
 None
 1.04A 3sudB-4bvxA:
undetectable		 3sudB-4bvxA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 ALA A  22
TYR A  68
ARG A  67
ALA B  65
 None
None
None
I3C  A1205 (-3.5A)
 1.12A 3twpC-4bvxA:
undetectable		 3twpC-4bvxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		3 / 3 GLN B 150
PHE B 146
TYR B 121
 None
 0.91A 3ucjB-4bvxB:
undetectable		 3ucjB-4bvxB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		3 / 3 GLN B 150
PHE B 146
TYR B 121
 None
 0.95A 3ucjA-4bvxB:
undetectable		 3ucjA-4bvxB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 PHE A  69
SER A  63
ALA A  64
LEU A 143
 None
 1.31A 5dzkg-4bvxA:
undetectable
5dzku-4bvxA:
undetectable		 5dzkg-4bvxA:
21.46
5dzku-4bvxA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4bvx METHIONINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 VAL A 189
PRO A 154
GLY A 150
TYR A 153
 None
 1.15A 5x80A-4bvxA:
undetectable
5x80B-4bvxA:
undetectable		 5x80A-4bvxA:
23.21
5x80B-4bvxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4bvx EUKARYOTIC
TRANSLATION
ELONGATION FACTOR 1
EPSILON-1
(Homo
sapiens) 		5 / 12 ILE B 118
TYR B  59
LEU B  10
ALA B  55
LEU B  16
 None
 1.42A 5zwrB-4bvxB:
undetectable		 5zwrB-4bvxB:
16.04