SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 LEU B 366
LEU B 357
ALA B 502
ALA B 497
VAL B 360
 None
P6G  B1546 ( 4.1A)
None
P6G  B1546 (-4.3A)
None
 1.27A 1kt4A-4bwcB:
undetectable		 1kt4A-4bwcB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 11 LEU B 357
ALA B 502
ALA B 497
VAL B 360
LEU B 366
 P6G  B1546 ( 4.1A)
None
P6G  B1546 (-4.3A)
None
None
 1.05A 1rlbF-4bwcB:
undetectable		 1rlbF-4bwcB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 THR A 107
LEU A 102
ILE A  81
ALA A  63
LEU B 545
 None
 1.20A 3a50A-4bwcA:
2.0		 3a50A-4bwcA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 ILE B 254
LEU A 102
ASN A  55
ILE A  81
LEU A 169
 None
 1.07A 3a50D-4bwcB:
undetectable		 3a50D-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 ILE B 254
LEU A 102
ASN A  55
ILE A  81
LEU A 169
 None
 1.14A 3a50E-4bwcB:
undetectable		 3a50E-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 10 ILE A  95
ALA A  98
ALA A  99
ALA A  42
VAL B 263
 None
 1.11A 3falA-4bwcA:
undetectable		 3falA-4bwcA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 6 GLU A 103
GLY A 104
LEU A  79
TYR A  67
 None
 1.13A 3w9tB-4bwcA:
undetectable		 3w9tB-4bwcA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 6 GLU A 103
GLY A 104
LEU A  79
TYR A  67
 None
 1.12A 3w9tE-4bwcA:
undetectable		 3w9tE-4bwcA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 6 GLU A 103
GLY A 104
LEU A  79
TYR A  67
 None
 1.13A 3w9tF-4bwcA:
undetectable		 3w9tF-4bwcA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 9 ALA A 195
GLY A 197
ASP A 201
LEU A 200
ILE A 203
 None
 1.39A 3wdmA-4bwcA:
undetectable		 3wdmA-4bwcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 11 TYR B 352
LEU A 118
GLN B 298
ILE A 196
TYR B 288
 None
None
OCS  B 225 ( 4.9A)
None
None
 1.37A 4a7aA-4bwcB:
undetectable		 4a7aA-4bwcB:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 5 TYR A  38
PRO A 109
ASN A  69
PRO B 278
 None
 1.37A 4eisA-4bwcA:
0.0
4eisB-4bwcA:
0.0		 4eisA-4bwcA:
18.78
4eisB-4bwcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIS_A_DAHA24_1
(POLYSACCHARIDE
MONOOXYGENASE-3)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 5 TYR A  38
PRO A 109
MET A 111
ASN A  69
 None
 1.13A 4eisA-4bwcA:
0.0
4eisB-4bwcA:
0.0		 4eisA-4bwcA:
18.78
4eisB-4bwcA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 GLN A 165
ALA A  99
LEU A 102
LEU A 106
TYR A  67
 None
 1.12A 4g1bA-4bwcA:
undetectable		 4g1bA-4bwcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		3 / 3 LEU B 228
MET B 444
TYR B 453
 None
 0.73A 4p6xG-4bwcB:
undetectable		 4p6xG-4bwcB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LI8_A_KKKA502_1
(PUTATIVE CYTOCHROME
P450 126)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 THR A 143
VAL B 374
ALA B 330
LYS B 342
ARG B 322
 None
 1.29A 5li8A-4bwcA:
0.0		 5li8A-4bwcA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		3 / 3 THR B 489
THR B 469
LEU B 514
 None
 0.47A 5m66D-4bwcB:
undetectable		 5m66D-4bwcB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
PHOSPHOLIPASE B-LIKE
1
(Bos
taurus;
Bos
taurus) 		3 / 3 GLY B 279
LEU A 193
HIS A 114
 None
 0.67A 5u63A-4bwcB:
undetectable		 5u63A-4bwcB:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		4 / 5 ASN B 455
GLN B 458
ASP B 459
ARG B 436
 None
 1.50A 5w4zA-4bwcB:
undetectable		 5w4zA-4bwcB:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4bwc PHOSPHOLIPASE B-LIKE
1
(Bos
taurus) 		5 / 12 ILE A  95
ALA A  98
ALA A  99
ALA A  42
VAL B 263
 None
 1.01A 5z12C-4bwcA:
undetectable		 5z12C-4bwcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 4bwc PHOSPHOLIPASE B-LIKE
1
PHOSPHOLIPASE B-LIKE
1
(Bos
taurus;
Bos
taurus) 		3 / 3 GLU B 528
ASP A 112
PRO A 109
 None
 0.70A 6berA-4bwcB:
undetectable		 6berA-4bwcB:
4.37