SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 11 PHE A 141
LEU A 321
ALA A 324
VAL A 317
LEU A 163
 None
 1.45A 1qabE-4bweA:
undetectable		 1qabE-4bweA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 163
LEU A 144
SER A 146
LEU A 115
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 1.14A 1qzfB-4bweA:
undetectable		 1qzfB-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 163
LEU A 144
SER A 146
LEU A 115
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 1.15A 1qzfC-4bweA:
undetectable		 1qzfC-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 163
LEU A 144
SER A 146
LEU A 115
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 1.15A 1qzfD-4bweA:
undetectable		 1qzfD-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 163
LEU A 144
SER A 146
LEU A 115
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 1.15A 1qzfE-4bweA:
undetectable		 1qzfE-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 163
LEU A 144
SER A 146
LEU A 115
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 1.19A 2oipD-4bweA:
undetectable		 2oipD-4bweA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		4 / 6 LEU A  85
SER A 395
PHE A 392
ASP A 391
 None
None
None
CA  A 503 (-2.5A)
 1.33A 2vn1B-4bweA:
undetectable		 2vn1B-4bweA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 GLU A 289
ASN A 292
SER A 296
LEU A 467
LEU A 104
 None
 1.50A 4k36A-4bweA:
undetectable		 4k36A-4bweA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 209
LEU A 144
SER A 146
SER A 316
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 0.83A 4ky8C-4bweA:
undetectable		 4ky8C-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.32A 4ojbA-4bweA:
undetectable		 4ojbA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.29A 4okbA-4bweA:
undetectable		 4okbA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.33A 4okxA-4bweA:
undetectable		 4okxA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 227
GLY A 226
LEU A 467
MET A 297
VAL A 298
 None
 1.39A 4olmA-4bweA:
undetectable		 4olmA-4bweA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 209
LEU A 144
SER A 146
SER A 316
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 0.83A 4q0dC-4bweA:
undetectable		 4q0dC-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 12 LEU A 209
LEU A 144
SER A 146
SER A 316
ARG A 149
 None
None
None
None
NAG  A 501 ( 4.5A)
 0.83A 4q0dD-4bweA:
undetectable		 4q0dD-4bweA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		3 / 3 GLU A 311
THR A 121
HIS A 318
 None
 0.67A 4q15A-4bweA:
undetectable		 4q15A-4bweA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_1
(PROLINE--TRNA LIGASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		3 / 3 GLU A 311
THR A 121
HIS A 318
 None
 0.67A 4q15B-4bweA:
undetectable		 4q15B-4bweA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4bwe GLYPICAN-1
(Homo
sapiens) 		5 / 11 LEU A 321
LEU A 144
GLU A 165
ALA A 164
LEU A 163
 None
 1.09A 4wg0J-4bweA:
undetectable
4wg0K-4bweA:
undetectable
4wg0L-4bweA:
undetectable		 4wg0J-4bweA:
2.10
4wg0K-4bweA:
2.10
4wg0L-4bweA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4bwe GLYPICAN-1
(Homo
sapiens) 		3 / 3 GLU A 311
THR A 121
HIS A 318
 None
 0.65A 4ydqB-4bweA:
undetectable		 4ydqB-4bweA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4bwe GLYPICAN-1
(Homo
sapiens) 		4 / 7 CSS A  32
GLN A  51
PRO A  50
ILE A  54
 None
 1.03A 4z4gA-4bweA:
undetectable		 4z4gA-4bweA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4bwe GLYPICAN-1
(Homo
sapiens) 		4 / 6 LEU A 396
SER A 395
PHE A 392
ASP A 391
 None
None
None
CA  A 503 (-2.5A)
 1.06A 5om3A-4bweA:
undetectable
5om3B-4bweA:
undetectable		 5om3A-4bweA:
12.25
5om3B-4bweA:
9.12