SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  80
SER A  96
ILE A  95
VAL A  84
ILE A  53
 None
 1.02A 2nnhA-4bwfA:
undetectable		 2nnhA-4bwfA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 136
LYS A 120
PRO A  93
LEU A  81
LEU A 116
 EDO  A1181 ( 4.6A)
None
None
None
None
 1.21A 2nv4A-4bwfA:
undetectable		 2nv4A-4bwfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  47
PRO A  93
LEU A 116
ILE A  95
 None
 0.89A 2q83A-4bwfA:
undetectable		 2q83A-4bwfA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  47
PRO A  93
LEU A 116
ILE A  95
 None
 0.87A 2q83B-4bwfA:
undetectable		 2q83B-4bwfA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  65
PRO A  93
LEU A 116
ILE A  95
 None
 0.96A 2q83B-4bwfA:
undetectable		 2q83B-4bwfA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  30
TYR A  26
VAL A 137
ILE A  47
 None
 1.31A 3ik3A-4bwfA:
undetectable		 3ik3A-4bwfA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  29
ASP A 129
ASN A  41
ILE A  46
LEU A  33
 None
 1.30A 3qg2B-4bwfA:
undetectable		 3qg2B-4bwfA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 1.03A 4a97E-4bwfA:
undetectable		 4a97E-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 0.86A 4a97D-4bwfA:
undetectable		 4a97D-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 1.08A 4a97G-4bwfA:
undetectable		 4a97G-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 177
ILE A 102
ASN A 101
GLU A  62
 None
 0.93A 4a97I-4bwfA:
undetectable		 4a97I-4bwfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 141
TYR A  73
LEU A 174
ARG A 177
 None
 1.33A 4em2A-4bwfA:
undetectable		 4em2A-4bwfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4bwf UBIQUITIN-CONJUGATIN
G ENZYME E2-21 KDA
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 107
PHE A 173
ARG A 177
 None
EDO  A1180 (-4.8A)
None
 0.93A 4xr4B-4bwfA:
undetectable		 4xr4B-4bwfA:
16.03