SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 7 LEU A 240
ALA A 225
THR A 221
VAL A 212
 None
 0.98A 1dvxB-4bwiA:
undetectable		 1dvxB-4bwiA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		3 / 3 ARG A 373
ARG A  85
ARG A 383
 CYC  A1422 ( 4.3A)
None
None
 1.08A 1l7fA-4bwiA:
undetectable		 1l7fA-4bwiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		3 / 3 ARG A 373
ARG A  85
ARG A 383
 CYC  A1422 ( 4.3A)
None
None
 1.08A 1l7hA-4bwiA:
undetectable		 1l7hA-4bwiA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		5 / 10 TYR A 133
ASP A  79
ARG A 383
VAL A 139
ILE A 156
 CYC  A1422 (-4.1A)
CYC  A1422 (-4.0A)
None
None
CYC  A1422 ( 4.7A)
 1.47A 1q6iB-4bwiA:
undetectable		 1q6iB-4bwiA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		5 / 11 TYR A 133
ASP A  79
ARG A 383
VAL A 139
ILE A 156
 CYC  A1422 (-4.1A)
CYC  A1422 (-4.0A)
None
None
CYC  A1422 ( 4.7A)
 1.40A 2fkeA-4bwiA:
undetectable		 2fkeA-4bwiA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 8 ASP A  79
TYR A  47
GLY A  55
PRO A  76
 CYC  A1422 (-4.0A)
CYC  A1422 (-4.2A)
None
None
 1.04A 2ys6A-4bwiA:
undetectable		 2ys6A-4bwiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 4 LEU A 406
ARG A 207
LEU A 208
ALA A 203
 None
 1.10A 3b9mA-4bwiA:
undetectable		 3b9mA-4bwiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		5 / 10 TYR A 133
ASP A  79
ARG A 383
VAL A 139
ILE A 156
 CYC  A1422 (-4.1A)
CYC  A1422 (-4.0A)
None
None
CYC  A1422 ( 4.7A)
 1.40A 3ihzA-4bwiA:
undetectable		 3ihzA-4bwiA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 6 LEU A 153
VAL A  30
ILE A  46
MET A  94
 GLU  A1427 ( 4.9A)
None
None
None
 1.16A 3k5vA-4bwiA:
undetectable		 3k5vA-4bwiA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 4 TRP A 222
LEU A 414
LEU A 208
THR A 211
 None
 1.47A 4bboD-4bwiA:
undetectable		 4bboD-4bwiA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		5 / 11 HIS A 130
PHE A  49
GLY A  89
MET A 148
GLU A  87
 CYC  A1422 (-3.5A)
None
GLU  A1427 (-3.2A)
None
None
 1.26A 4fglA-4bwiA:
undetectable
4fglB-4bwiA:
undetectable		 4fglA-4bwiA:
20.59
4fglB-4bwiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 8 ASN A  90
ARG A  92
LEU A 153
ILE A  80
 GLU  A1427 (-3.2A)
None
GLU  A1427 ( 4.9A)
CYC  A1422 (-4.0A)
 1.09A 4l7iA-4bwiA:
undetectable		 4l7iA-4bwiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 6 GLY A 354
TYR A 241
ALA A 243
ARG A 276
 None
 1.30A 4yshB-4bwiA:
undetectable		 4yshB-4bwiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		6 / 9 LEU A 204
LEU A 208
ALA A 225
LEU A 414
LEU A 356
ALA A 232
 None
 1.23A 4z91F-4bwiA:
1.8
4z91G-4bwiA:
1.8
4z91H-4bwiA:
1.7
4z91I-4bwiA:
1.8
4z91J-4bwiA:
1.9		 4z91F-4bwiA:
22.61
4z91G-4bwiA:
22.61
4z91H-4bwiA:
22.61
4z91I-4bwiA:
22.61
4z91J-4bwiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		6 / 9 LEU A 414
LEU A 356
ALA A 232
LEU A 204
LEU A 208
ALA A 225
 None
 1.25A 4z91F-4bwiA:
1.8
4z91G-4bwiA:
1.8
4z91H-4bwiA:
1.7
4z91I-4bwiA:
1.8
4z91J-4bwiA:
1.9		 4z91F-4bwiA:
22.61
4z91G-4bwiA:
22.61
4z91H-4bwiA:
22.61
4z91I-4bwiA:
22.61
4z91J-4bwiA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 8 SER A 411
ALA A 410
PRO A 312
LEU A 342
 None
 1.06A 5dzkd-4bwiA:
undetectable
5dzkr-4bwiA:
undetectable		 5dzkd-4bwiA:
21.83
5dzkr-4bwiA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		4 / 8 SER A 411
ALA A 410
PRO A 312
LEU A 342
 None
 0.99A 5dzkF-4bwiA:
undetectable
5dzkT-4bwiA:
undetectable		 5dzkF-4bwiA:
21.83
5dzkT-4bwiA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4bwi PHYTOCHROME-LIKE
PROTEIN CPH2
(Synechocystis
sp.) 		5 / 10 TYR A 133
ASP A  79
ARG A 383
VAL A 139
ILE A 156
 CYC  A1422 (-4.1A)
CYC  A1422 (-4.0A)
None
None
CYC  A1422 ( 4.7A)
 1.45A 6mkeD-4bwiA:
undetectable		 6mkeD-4bwiA:
15.90