SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 12 LEU A 487
LEU A 491
LEU A 509
ALA A 393
PHE A 453
 None
 0.95A 1gseB-4bwkA:
undetectable		 1gseB-4bwkA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 11 LEU A 409
GLY A 454
VAL A 490
LEU A 491
LEU A 396
 None
 1.08A 1mx1A-4bwkA:
undetectable		 1mx1A-4bwkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 12 LEU A 396
LEU A 423
ILE A 456
ILE A 513
LEU A 509
 None
 1.09A 1tw4A-4bwkA:
undetectable		 1tw4A-4bwkA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		3 / 3 LEU A 616
LEU A 573
MET A 635
 None
 0.52A 1ya3B-4bwkA:
undetectable		 1ya3B-4bwkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 10 ALA A 406
LEU A 423
LEU A 396
ALA A 395
VAL A 506
 None
 1.07A 2bxgB-4bwkA:
undetectable		 2bxgB-4bwkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		4 / 5 ARG A 482
THR A 478
LEU A 476
ALA A 461
 None
 1.35A 2e1qD-4bwkA:
undetectable		 2e1qD-4bwkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		3 / 3 LEU A 258
PRO A 259
LEU A 267
 None
 0.59A 2po7B-4bwkA:
undetectable		 2po7B-4bwkA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		4 / 6 LEU A 573
PHE A 625
LEU A 616
ASP A 620
 None
 1.02A 2wm3A-4bwkA:
undetectable		 2wm3A-4bwkA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		4 / 7 ILE A 315
TYR A 351
VAL A 333
LEU A 432
 None
 0.93A 3elzA-4bwkA:
undetectable		 3elzA-4bwkA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		3 / 3 ASN A 597
HIS A 598
VAL A 582
 None
 0.77A 3elzB-4bwkA:
undetectable		 3elzB-4bwkA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 12 LEU A 301
ASN A 292
LEU A 261
THR A 339
TYR A 288
 None
 0.95A 3fsuA-4bwkA:
undetectable		 3fsuA-4bwkA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		4 / 8 TRP A 386
LEU A 491
GLY A 512
ILE A 513
 None
 0.85A 3wxoA-4bwkA:
1.0		 3wxoA-4bwkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bwk PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3
(Neurospora
crassa) 		5 / 12 ILE A 456
LEU A 409
TRP A 493
VAL A 506
ALA A 393
 None
 1.39A 4m11C-4bwkA:
1.6		 4m11C-4bwkA:
22.94