SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 10 THR A 524
ILE A 525
LEU A 532
LEU A 596
ILE A 635
None
1.41A 1i18A-4bwpA:
undetectable
1i18B-4bwpA:
undetectable
1i18A-4bwpA:
12.81
1i18B-4bwpA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
4 / 5 LEU A 596
ILE A 554
GLY A 535
HIS A 540
None
0.77A 2otfA-4bwpA:
undetectable
2otfA-4bwpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 11 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
None
0.95A 2qd3A-4bwpA:
undetectable
2qd3A-4bwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 ALA A 406
THR A 572
ARG A 423
LEU A 469
GLN A 431
None
None
AN2  A1788 (-2.8A)
None
None
1.36A 2rctA-4bwpA:
undetectable
2rctA-4bwpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_B_ADNB1588_1
(ACSD)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 10 LEU A 757
SER A 759
ARG A 760
LEU A 716
ASN A 696
None
1.25A 2w03B-4bwpA:
6.6
2w03B-4bwpA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
3 / 3 MET A 785
GLU A 778
ASP A 748
None
0.96A 3a25A-4bwpA:
undetectable
3a25A-4bwpA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 VAL A 647
HIS A 540
PHE A 563
GLY A 597
LEU A 599
None
1.23A 3j6pB-4bwpA:
undetectable
3j6pB-4bwpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 GLY A 597
ALA A 602
LEU A 603
ARG A 645
ILE A 654
None
0.96A 3mb5A-4bwpA:
undetectable
3mb5A-4bwpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
4 / 5 HIS A 474
LEU A 480
LEU A 532
ASP A 550
None
1.23A 4aqlA-4bwpA:
undetectable
4aqlA-4bwpA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
None
0.96A 4f4dA-4bwpA:
undetectable
4f4dA-4bwpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
None
0.95A 4f4dB-4bwpA:
undetectable
4f4dB-4bwpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 9 VAL A 561
ILE A 554
HIS A 540
LEU A 593
LEU A 596
None
1.46A 4l1xB-4bwpA:
undetectable
4l1xB-4bwpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 10 LEU A 599
LEU A 596
LEU A 593
ILE A 554
THR A 648
None
1.01A 4mk4A-4bwpA:
undetectable
4mk4A-4bwpA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 ASP A 550
LEU A 549
LEU A 532
LEU A 480
ILE A 554
None
0.97A 4x1fA-4bwpA:
undetectable
4x1fA-4bwpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
5 / 12 ASP A 550
LEU A 549
LEU A 532
LEU A 480
ILE A 554
None
0.99A 4x1gA-4bwpA:
undetectable
4x1gA-4bwpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster)
4 / 6 VAL A 755
LEU A 757
CYH A 743
LEU A 723
None
1.17A 5hrqB-4bwpA:
undetectable
5hrqI-4bwpA:
undetectable
5hrqJ-4bwpA:
undetectable
5hrqB-4bwpA:
5.96
5hrqI-4bwpA:
4.02
5hrqJ-4bwpA:
5.96