SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		5 / 12 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.01A 1epbA-4bwsA:
undetectable		 1epbA-4bwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		5 / 12 PHE A  83
ILE A 115
VAL A  27
ALA A  56
ILE A  58
 None
 1.04A 1epbB-4bwsA:
undetectable		 1epbB-4bwsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		3 / 3 GLU A  65
HIS A   9
ASP A  33
 None
 0.81A 1i9gA-4bwsA:
undetectable		 1i9gA-4bwsA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		4 / 7 TYR A 136
GLU A 107
TRP A 104
LEU A  94
 None
 1.28A 3k8mA-4bwsA:
undetectable		 3k8mA-4bwsA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		5 / 10 ILE A  92
PHE A  83
LEU A  45
ILE A 102
TYR A 136
 None
 1.32A 4km0A-4bwsA:
undetectable		 4km0A-4bwsA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
POLYGLUTAMINE-BINDIN
G PROTEIN 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN A  87
SER B 247
ARG B 253
 None
 0.73A 5b2qA-4bwsA:
undetectable		 5b2qA-4bwsA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		3 / 3 GLU A  65
HIS A   9
ASP A  33
 None
 0.73A 5c0oG-4bwsA:
undetectable		 5c0oG-4bwsA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 4bws THIOREDOXIN-LIKE
PROTEIN 4A
(Homo
sapiens) 		3 / 3 TYR A  73
HIS A  89
PHE A  84
 None
 1.02A 6esmA-4bwsA:
undetectable		 6esmA-4bwsA:
20.42