SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		4 / 6 PRO A 115
PHE A 114
LYS A 245
VAL A 246
 None
 1.40A 1l2iB-4bwvA:
undetectable		 1l2iB-4bwvA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		4 / 4 ASP A 227
HIS A 228
ARG A 225
GLU A 299
 None
 1.48A 1lqtA-4bwvA:
2.5		 1lqtA-4bwvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		3 / 3 TRP A 293
PHE A 254
TRP A 258
 PEG  A 563 ( 4.7A)
None
PEG  A 563 ( 4.3A)
 1.46A 1r15C-4bwvA:
undetectable		 1r15C-4bwvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		3 / 3 TRP A 293
PHE A 254
TRP A 258
 PEG  A 563 ( 4.7A)
None
PEG  A 563 ( 4.3A)
 1.46A 1r15F-4bwvA:
undetectable		 1r15F-4bwvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		3 / 3 TRP A 293
PHE A 254
TRP A 258
 PEG  A 563 ( 4.7A)
None
PEG  A 563 ( 4.3A)
 1.45A 1r15G-4bwvA:
undetectable		 1r15G-4bwvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		3 / 3 TRP A 293
PHE A 254
TRP A 258
 PEG  A 563 ( 4.7A)
None
PEG  A 563 ( 4.3A)
 1.46A 1r15H-4bwvA:
undetectable		 1r15H-4bwvA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		3 / 3 ARG A 131
TYR A 264
LYS A 263
 None
 1.01A 1uujB-4bwvA:
undetectable		 1uujB-4bwvA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		5 / 7 ILE A 143
PRO A 248
ILE A 125
LEU A 129
ILE A 221
 None
 1.48A 2q83A-4bwvA:
undetectable		 2q83A-4bwvA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 4bwv PHOSPHOADENOSINE-PHO
SPHOSULPHATE
REDUCTASE
(Physcomitrella
patens) 		5 / 11 ILE A 125
LEU A  99
LEU A 129
ILE A 132
THR A 105
 None
 1.39A 3a50B-4bwvA:
undetectable		 3a50B-4bwvA:
21.01