SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bwy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 4bwy P4
(Pseudomonas
phage
phi8) 		3 / 3 ARG A 263
GLY A 104
ASP A 201
 None
 0.59A 1kf6A-4bwyA:
undetectable
1kf6B-4bwyA:
undetectable		 1kf6A-4bwyA:
18.62
1kf6B-4bwyA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4bwy P4
(Pseudomonas
phage
phi8) 		4 / 5 ARG A 210
THR A 240
LEU A 107
ALA A 105
 None
 1.49A 2e1qD-4bwyA:
undetectable		 2e1qD-4bwyA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 LEU A 200
ALA A 234
ILE A 109
LEU A 215
LEU A 173
 None
 0.95A 3adxB-4bwyA:
undetectable		 3adxB-4bwyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		4 / 8 HIS A 239
ASP A 265
LEU A 262
ILE A 260
 None
 0.91A 4k0bA-4bwyA:
undetectable		 4k0bA-4bwyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		4 / 8 HIS A 239
ASP A 265
LEU A 262
ILE A 260
 None
 0.92A 4l7iA-4bwyA:
undetectable		 4l7iA-4bwyA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 4bwy P4
(Pseudomonas
phage
phi8) 		3 / 3 LEU A 132
MET A 209
TYR A 123
 None
 0.81A 4p6xG-4bwyA:
undetectable		 4p6xG-4bwyA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 11 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.42A 4ygfA-4bwyA:
undetectable		 4ygfA-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 11 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.36A 4ygfC-4bwyA:
undetectable		 4ygfC-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 11 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.33A 4ygfD-4bwyA:
undetectable		 4ygfD-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.29A 4ygfG-4bwyA:
undetectable		 4ygfG-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 10 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.31A 4yhaB-4bwyA:
undetectable		 4yhaB-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 ASN A 314
VAL A 150
VAL A 176
LEU A 200
ALA A 199
 None
 1.36A 4yhaG-4bwyA:
undetectable		 4yhaG-4bwyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 SER A  88
HIS A 158
HIS A  62
ASP A  65
GLY A  64
 None
 1.27A 5eenA-4bwyA:
undetectable		 5eenA-4bwyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 VAL A  21
LEU A 173
ALA A 156
THR A 214
ARG A 174
 None
 1.04A 5hnzB-4bwyA:
undetectable		 5hnzB-4bwyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)		 4bwy P4
(Pseudomonas
phage
phi8) 		4 / 5 ASN A 183
ASP A 219
SER A 218
ARG A 174
 None
 1.11A 5w4zA-4bwyA:
3.0		 5w4zA-4bwyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 4bwy P4
(Pseudomonas
phage
phi8) 		4 / 6 LEU A 173
VAL A 176
LEU A 180
VAL A 150
 None
 0.94A 5x7zA-4bwyA:
undetectable		 5x7zA-4bwyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4bwy P4
(Pseudomonas
phage
phi8) 		5 / 12 VAL A 211
ALA A 105
GLY A 104
LEU A 173
LEU A 157
 None
 0.91A 6f6iA-4bwyA:
undetectable
6f6iB-4bwyA:
undetectable		 6f6iA-4bwyA:
14.02
6f6iB-4bwyA:
15.53