SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 11 ILE A 311
VAL A 354
ALA A 355
PHE A 365
ILE A 315
 None
 1.29A 1uduA-4bxiA:
undetectable		 1uduA-4bxiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 ILE A 293
SER A 320
LYS A 289
PRO A 316
ILE A 297
 None
 1.11A 3cd2A-4bxiA:
undetectable		 3cd2A-4bxiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.13A 4coxA-4bxiA:
undetectable		 4coxA-4bxiA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.13A 4coxB-4bxiA:
undetectable		 4coxB-4bxiA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.14A 4coxD-4bxiA:
undetectable		 4coxD-4bxiA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		4 / 8 PHE A 356
GLU A 318
SER A 320
VAL A 290
 None
None
None
GOL  A1432 ( 4.7A)
 1.36A 4d32A-4bxiA:
undetectable
4d32B-4bxiA:
undetectable		 4d32A-4bxiA:
17.55
4d32B-4bxiA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		3 / 3 LYS A 300
LEU A 296
ALA A 299
 None
 0.81A 4iizA-4bxiA:
undetectable		 4iizA-4bxiA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 ILE A 336
ILE A 313
LEU A 288
VAL A 319
ILE A 333
 None
 1.01A 4m2xG-4bxiA:
undetectable		 4m2xG-4bxiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.02A 4rrxA-4bxiA:
undetectable		 4rrxA-4bxiA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.03A 4rrxB-4bxiA:
undetectable		 4rrxB-4bxiA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.06A 5ikqA-4bxiA:
undetectable		 5ikqA-4bxiA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4bxi ACCESSORY GENE
REGULATOR PROTEIN C
(Staphylococcus
aureus) 		5 / 12 VAL A 425
LEU A 296
GLY A 334
SER A 332
LEU A 400
 None
 1.07A 5ikqB-4bxiA:
undetectable		 5ikqB-4bxiA:
13.63