SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bxj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 246
ALA A 244
ILE A 245
ALA A 237
PHE A 225
 None
 1.20A 1xp0A-4bxjA:
undetectable		 1xp0A-4bxjA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 146
VAL A 144
VAL A  23
LEU A  91
 None
 0.93A 2gehA-4bxjA:
undetectable		 2gehA-4bxjA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 12 SER A  44
HIS A  46
HIS A  79
VAL A  19
LEU A  22
 None
 1.47A 3lxeA-4bxjA:
undetectable		 3lxeA-4bxjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  91
PHE A  21
GLU A  73
GLY A  97
VAL A  19
 None
 0.89A 3nk7B-4bxjA:
undetectable		 3nk7B-4bxjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 217
ALA A 224
GLY A 152
HIS A 146
LEU A 222
 None
 1.26A 3pfgA-4bxjA:
undetectable		 3pfgA-4bxjA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 156
ARG A 153
LYS A 154
 None
 0.92A 3wipG-4bxjA:
undetectable		 3wipG-4bxjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 165
GLU A 117
ASN A 122
GLN A  65
 None
 0.88A 4f93B-4bxjA:
undetectable		 4f93B-4bxjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		4 / 5 GLU A 165
SER A 119
GLN A  65
ASP A 115
 None
 1.39A 5fhrB-4bxjA:
undetectable		 5fhrB-4bxjA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  38
VAL A  71
HIS A  46
VAL A  23
GLY A  81
 None
 1.21A 5i8fA-4bxjA:
undetectable		 5i8fA-4bxjA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 166
ILE A 171
GLY A 170
LEU A 124
ALA A 128
 None
 1.01A 5o96A-4bxjA:
undetectable
5o96B-4bxjA:
undetectable		 5o96A-4bxjA:
22.58
5o96B-4bxjA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		4 / 8 HIS A 146
VAL A 144
VAL A  23
LEU A  91
 None
 0.82A 5tt3F-4bxjA:
undetectable		 5tt3F-4bxjA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		3 / 3 TYR A 207
HIS A 228
MET A 227
 None
 0.94A 6af6A-4bxjA:
undetectable		 6af6A-4bxjA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 4bxj AMPDH3
(Pseudomonas
aeruginosa) 		5 / 9 ALA A  37
SER A  34
ALA A  43
GLY A  41
ALA A  45
 None
 1.09A 6bklE-4bxjA:
undetectable
6bklF-4bxjA:
undetectable
6bklG-4bxjA:
undetectable
6bklH-4bxjA:
undetectable		 6bklE-4bxjA:
6.80
6bklF-4bxjA:
6.80
6bklG-4bxjA:
6.80
6bklH-4bxjA:
6.80