SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bxm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 LEU A  39
TYR A 146
ASN A 107
TYR A  68
 None
 1.14A 1afsA-4bxmA:
undetectable		 1afsA-4bxmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 TYR A 146
THR A  71
ASN A 107
TYR A  68
 None
 1.40A 1afsA-4bxmA:
undetectable		 1afsA-4bxmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 LEU A  39
TYR A 146
ASN A 107
TYR A  68
 None
 1.14A 1afsB-4bxmA:
undetectable		 1afsB-4bxmA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
SER A  74
LEU A  75
THR A  53
 None
 0.97A 1sbrA-4bxmA:
undetectable		 1sbrA-4bxmA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 2eijN-4bxmA:
undetectable
2eijW-4bxmA:
undetectable		 2eijN-4bxmA:
15.42
2eijW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 2eikA-4bxmA:
undetectable
2eikJ-4bxmA:
undetectable		 2eikA-4bxmA:
15.42
2eikJ-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 2eikN-4bxmA:
undetectable
2eikW-4bxmA:
undetectable		 2eikN-4bxmA:
15.42
2eikW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.73A 2eilN-4bxmA:
undetectable
2eilW-4bxmA:
undetectable		 2eilN-4bxmA:
15.42
2eilW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.79A 3ablN-4bxmA:
undetectable
3ablW-4bxmA:
undetectable		 3ablN-4bxmA:
15.42
3ablW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 3ag3N-4bxmA:
undetectable
3ag3W-4bxmA:
undetectable		 3ag3N-4bxmA:
15.42
3ag3W-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.80A 3asnN-4bxmA:
undetectable
3asnW-4bxmA:
undetectable		 3asnN-4bxmA:
15.42
3asnW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 6 ILE A  27
THR A 118
PHE A  93
PHE A  73
 None
 1.26A 3elzB-4bxmA:
2.6		 3elzB-4bxmA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4bxm ERPC
(Borreliella
burgdorferi) 		5 / 10 LEU A  75
VAL A  44
ILE A  84
LEU A 157
PHE A  20
 None
 1.20A 3fl9F-4bxmA:
undetectable		 3fl9F-4bxmA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4bxm ERPC
(Borreliella
burgdorferi) 		3 / 3 GLU A 104
GLY A 133
SER A 106
 None
 0.36A 4b53B-4bxmA:
undetectable		 4b53B-4bxmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 TYR A 146
GLY A 133
SER A  96
PHE A 131
 None
 0.84A 5alcL-4bxmA:
undetectable		 5alcL-4bxmA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.80A 5b1bN-4bxmA:
undetectable
5b1bW-4bxmA:
undetectable		 5b1bN-4bxmA:
15.42
5b1bW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.80A 5b3sN-4bxmA:
undetectable
5b3sW-4bxmA:
undetectable		 5b3sN-4bxmA:
15.42
5b3sW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 7 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.74A 5iy5N-4bxmA:
undetectable
5iy5W-4bxmA:
undetectable		 5iy5N-4bxmA:
15.42
5iy5W-4bxmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.80A 5xdxN-4bxmA:
undetectable
5xdxW-4bxmA:
undetectable		 5xdxN-4bxmA:
15.42
5xdxW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.81A 5zcoA-4bxmA:
undetectable
5zcoJ-4bxmA:
undetectable		 5zcoA-4bxmA:
15.42
5zcoJ-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4bxm ERPC
(Borreliella
burgdorferi) 		4 / 8 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.81A 5zcqN-4bxmA:
undetectable
5zcqW-4bxmA:
undetectable		 5zcqN-4bxmA:
15.42
5zcqW-4bxmA:
21.01