SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.04A 1icrA-4bxoA:
undetectable
1icrB-4bxoA:
undetectable		 1icrA-4bxoA:
19.48
1icrB-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 GLU A1826
GLY A1823
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.04A 1icrA-4bxoA:
undetectable
1icrB-4bxoA:
undetectable		 1icrA-4bxoA:
19.48
1icrB-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 GLU A1826
GLY A1824
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.22A 1icrA-4bxoA:
undetectable
1icrB-4bxoA:
undetectable		 1icrA-4bxoA:
19.48
1icrB-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_A_NIOA221_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.07A 1icuA-4bxoA:
undetectable
1icuB-4bxoA:
undetectable		 1icuA-4bxoA:
19.48
1icuB-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_B_NIOB219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 GLU A1826
GLY A1823
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.04A 1icuA-4bxoA:
undetectable
1icuB-4bxoA:
undetectable		 1icuA-4bxoA:
19.48
1icuB-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.05A 1icuC-4bxoA:
undetectable
1icuD-4bxoA:
undetectable		 1icuC-4bxoA:
19.48
1icuD-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.04A 1icvC-4bxoA:
undetectable
1icvD-4bxoA:
undetectable		 1icvC-4bxoA:
19.48
1icvD-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 GLU A1826
GLY A1823
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.03A 1icvC-4bxoA:
undetectable
1icvD-4bxoA:
undetectable		 1icvC-4bxoA:
19.48
1icvD-4bxoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		5 / 10 VAL A1896
PHE A1880
LEU A1922
TYR A1918
LEU A1872
 None
 1.38A 1j78B-4bxoA:
0.6		 1j78B-4bxoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.07A 1kqbA-4bxoA:
undetectable
1kqbB-4bxoA:
undetectable		 1kqbA-4bxoA:
19.39
1kqbB-4bxoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 GLU A1826
GLY A1823
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.07A 1kqbA-4bxoA:
undetectable
1kqbB-4bxoA:
undetectable		 1kqbA-4bxoA:
19.39
1kqbB-4bxoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 5 GLU A1826
GLY A1824
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.24A 1kqbA-4bxoA:
undetectable
1kqbB-4bxoA:
undetectable		 1kqbA-4bxoA:
19.39
1kqbB-4bxoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_C_BEZC522_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 SER A1829
THR A1828
GLU A1826
GLY A1823
 None
None
CA  A2050 ( 4.8A)
None
 1.04A 1kqbC-4bxoA:
undetectable
1kqbD-4bxoA:
undetectable		 1kqbC-4bxoA:
19.39
1kqbD-4bxoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 GLU A1826
GLY A1823
SER A1829
THR A1828
 CA  A2050 ( 4.8A)
None
None
None
 1.06A 1kqbC-4bxoA:
undetectable
1kqbD-4bxoA:
undetectable		 1kqbC-4bxoA:
19.39
1kqbD-4bxoA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		5 / 9 LEU A1925
ILE A1930
GLY A1929
LEU A1921
SER A1920
 None
 1.12A 3ai9X-4bxoA:
undetectable		 3ai9X-4bxoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 8 TYR A1976
MET A2000
SER A2003
SER A1995
 None
 1.02A 3lsfH-4bxoA:
undetectable		 3lsfH-4bxoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		5 / 8 TYR A1918
LEU A1925
VAL A1896
VAL A1898
GLN A1868
 None
 1.41A 4em2A-4bxoA:
undetectable		 4em2A-4bxoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1930
MET A1861
ARG A1860
 None
 0.82A 4lnwA-4bxoA:
undetectable		 4lnwA-4bxoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		3 / 3 ILE A1930
MET A1861
ARG A1860
 None
 0.85A 4lnxA-4bxoA:
undetectable		 4lnxA-4bxoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4bxo FANCONI ANEMIA GROUP
M PROTEIN
(Homo
sapiens) 		4 / 6 LYS A1877
VAL A1898
ILE A1932
TYR A1918
 None
 1.42A 5q1sA-4bxoA:
undetectable		 5q1sA-4bxoA:
22.00