SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4bxw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		7 / 8 HIS A 211
ASP A 356
GLN A 359
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.70A 1aq7A-4bxwA:
33.0		 1aq7A-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		6 / 9 ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.37A 1bcuH-4bxwA:
34.2		 1bcuH-4bxwA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 ILE A 402
ALA A 292
THR A 396
ILE A 379
LEU A 207
 None
 1.17A 1ddsA-4bxwA:
undetectable		 1ddsA-4bxwA:
15.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		6 / 12 HIS A 211
ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.69A 1etrH-4bxwA:
32.9		 1etrH-4bxwA:
38.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 8 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.39A 1f5lA-4bxwA:
31.7		 1f5lA-4bxwA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 10 SER A 362
SER A 381
ILE A 379
GLY A 378
GLY A 393
 0GJ  A1411 (-1.4A)
None
None
None
0GJ  A1411 (-3.3A)
 1.24A 1mehA-4bxwA:
undetectable		 1mehA-4bxwA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 GLY A 364
GLY A 197
VAL A 221
LEU A 187
LEU A 207
 None
 1.07A 1mx1F-4bxwA:
undetectable		 1mx1F-4bxwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 8 ASP A 265
PHE A 248
SER A 362
ALA A 267
 None
None
0GJ  A1411 (-1.4A)
None
 1.09A 1rqpC-4bxwA:
undetectable		 1rqpC-4bxwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 6 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.34A 1tnlA-4bxwA:
32.8		 1tnlA-4bxwA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 11 LEU A 201
LEU A 286
ILE A 266
THR A 396
ASN A 344
 None
 1.25A 2ft9A-4bxwA:
undetectable		 2ft9A-4bxwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 6 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.21A 2otvA-4bxwA:
33.0		 2otvA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		6 / 12 GLY A 308
GLY A 198
GLY A 363
GLY A 360
THR A 208
LEU A 207
 None
None
None
0GJ  A1411 (-3.8A)
None
None
 1.45A 2oxtD-4bxwA:
undetectable		 2oxtD-4bxwA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4bxw FACTOR XA
(Pseudonaja
textilis) 		8 / 12 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 393
TYR A 395
 0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
None
 0.42A 2p16A-4bxwA:
38.9		 2p16A-4bxwA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 8 ASP A 356
SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.40A 2vinA-4bxwA:
9.5		 2vinA-4bxwA:
22.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		9 / 12 TYR A 262
ASP A 356
ALA A 357
SER A 362
VAL A 380
GLY A 383
GLY A 385
GLY A 393
TYR A 395
 0GJ  A1411 ( 3.5A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
None
0GJ  A1411 (-3.3A)
None
 0.39A 2w26A-4bxwA:
38.8		 2w26A-4bxwA:
55.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 ILE A 275
ILE A 408
TYR A 243
LEU A 237
 None
 1.15A 3adsA-4bxwA:
undetectable		 3adsA-4bxwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		6 / 11 HIS A 211
ASP A 356
GLN A 359
SER A 362
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-1.4A)
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.62A 3gy3A-4bxwA:
32.7		 3gy3A-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 ASN A  95
ILE A 107
LYS A  89
ASN A  93
 None
 1.42A 3kp6A-4bxwA:
undetectable
3kp6B-4bxwA:
undetectable		 3kp6A-4bxwA:
16.16
3kp6B-4bxwA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 GLY A 363
GLN A 184
ILE A 379
VAL A 380
 None
 1.14A 3kvvD-4bxwA:
undetectable		 3kvvD-4bxwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 GLY A 363
GLN A 184
ILE A 379
VAL A 380
 None
 1.15A 3kvvE-4bxwA:
undetectable		 3kvvE-4bxwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 GLY A 363
GLN A 184
ILE A 379
VAL A 380
 None
 1.13A 3kvvF-4bxwA:
undetectable		 3kvvF-4bxwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 LYS A 170
GLY A 364
ILE A 379
ALA A 209
ASP A 361
 None
 1.07A 3nvkI-4bxwA:
undetectable		 3nvkI-4bxwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 6 SER A 362
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.34A 3rxfA-4bxwA:
13.5		 3rxfA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 5 ASP A 356
SER A 362
VAL A 380
GLY A 393
 0GJ  A1411 (-2.7A)
0GJ  A1411 (-1.4A)
None
0GJ  A1411 (-3.3A)
 0.39A 3rxhA-4bxwA:
33.0		 3rxhA-4bxwA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 7 GLY A 179
PRO A 182
ASN A 280
GLY A 133
THR A 373
 None
 1.37A 3tajA-4bxwA:
undetectable		 3tajA-4bxwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 10 LEU A 207
ILE A 269
ILE A 379
GLY A 363
GLY A 197
 None
 0.95A 4fakA-4bxwA:
undetectable		 4fakA-4bxwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 10 LEU A 207
ILE A 269
ILE A 379
GLY A 364
GLY A 197
 None
 0.93A 4fakA-4bxwA:
undetectable		 4fakA-4bxwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 5 HIS A 211
GLN A 359
GLY A 360
SER A 362
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-3.6A)
0GJ  A1411 (-3.8A)
0GJ  A1411 (-1.4A)
 0.96A 4fu8A-4bxwA:
31.9		 4fu8A-4bxwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 HIS A 211
ASP A 356
ALA A 357
VAL A 380
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-2.7A)
0GJ  A1411 (-3.4A)
None
0GJ  A1411 (-3.3A)
 0.27A 4hfpD-4bxwA:
33.1		 4hfpD-4bxwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 GLY A 364
PRO A 365
LEU A 187
THR A 216
GLY A 360
 None
None
None
None
0GJ  A1411 (-3.8A)
 1.27A 4n48A-4bxwA:
undetectable		 4n48A-4bxwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 HIS A 211
ALA A 357
VAL A 380
GLY A 383
GLY A 393
 0GJ  A1411 (-2.8A)
0GJ  A1411 (-3.4A)
None
0GJ  A1411 (-3.7A)
0GJ  A1411 (-3.3A)
 0.84A 4rn6B-4bxwA:
29.1		 4rn6B-4bxwA:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 9 PRO A 365
LEU A 187
ILE A 379
LEU A 207
THR A 208
 None
 1.21A 4x3mB-4bxwA:
undetectable		 4x3mB-4bxwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 8 ASN A 135
PRO A 182
SER A 131
TYR A 115
 None
 1.34A 5amiB-4bxwA:
undetectable		 5amiB-4bxwA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 12 TYR A 327
ASN A 135
HIS A 374
LEU A 207
ILE A 376
 None
 1.34A 5dv4A-4bxwA:
undetectable		 5dv4A-4bxwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		5 / 9 LEU A 187
THR A 208
ILE A 269
VAL A 239
ILE A 219
 None
 1.13A 6ef6A-4bxwA:
undetectable		 6ef6A-4bxwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4bxw FACTOR XA
(Pseudonaja
textilis) 		4 / 5 ILE A 376
GLN A 184
THR A 199
THR A 368
 None
 1.08A 6f3mD-4bxwA:
undetectable		 6f3mD-4bxwA:
21.02