SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4by2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4by2 ANASTRAL SPINDLE 2,
SAS 4
(Drosophila
melanogaster) 		4 / 5 GLU A 136
THR A 142
HIS A 144
HIS A 125
 None
 1.49A 1d4fA-4by2A:
undetectable		 1d4fA-4by2A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4by2 ANASTRAL SPINDLE 2,
SAS 4
(Drosophila
melanogaster) 		4 / 6 LEU A 135
GLU A 136
THR A 113
TYR A 118
 None
 1.40A 1qvuA-4by2A:
undetectable		 1qvuA-4by2A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4by2 ANASTRAL SPINDLE 2,
SAS 4
(Drosophila
melanogaster) 		3 / 3 TRP A 124
GLN A 141
THR A 123
 None
 0.93A 4m2xA-4by2A:
undetectable		 4m2xA-4by2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4by2 ANASTRAL SPINDLE 2,
SAS 4
(Drosophila
melanogaster) 		5 / 12 ASN A 122
GLU A 136
TYR A 117
SER A 127
HIS A 125
 None
 1.23A 5lsaA-4by2A:
undetectable		 5lsaA-4by2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4by2 ANASTRAL SPINDLE 2,
SAS 4
(Drosophila
melanogaster) 		3 / 3 HIS A 154
HIS A 144
ARG A 146
 None
 1.04A 6b58A-4by2A:
undetectable		 6b58A-4by2A:
19.54