SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4by4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 LYS A  63
ASP A 111
ASN A 123
 None
CA  A1185 (-2.7A)
None
 1.07A 2bm9A-4by4A:
undetectable		 2bm9A-4by4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 ARG A 147
LYS A 146
LYS A 150
 None
 1.38A 4k50A-4by4A:
undetectable		 4k50A-4by4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 ARG A 147
LYS A 146
LYS A 150
 None
 1.39A 4k50E-4by4A:
undetectable		 4k50E-4by4A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 0.72A 4qa0B-4by4A:
undetectable		 4qa0B-4by4A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 0.69A 4qa0A-4by4A:
undetectable		 4qa0A-4by4A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 0.81A 4qa2B-4by4A:
undetectable		 4qa2B-4by4A:
18.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4by4 FI18190P1
(Drosophila
melanogaster) 		5 / 6 ILE A  51
TYR A  52
PHE A  72
THR A  92
TRP A 103
 None
 0.43A 5g08A-4by4A:
23.6		 5g08A-4by4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4by4 FI18190P1
(Drosophila
melanogaster) 		5 / 6 TYR A  52
PHE A  55
PHE A  72
THR A  92
TRP A 103
 None
 0.81A 5g08A-4by4A:
23.6		 5g08A-4by4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4by4 FI18190P1
(Drosophila
melanogaster) 		5 / 6 TYR A  52
PHE A  56
PHE A  72
THR A  92
TRP A 103
 None
 1.43A 5g08A-4by4A:
23.6		 5g08A-4by4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4by4 FI18190P1
(Drosophila
melanogaster) 		3 / 3 TYR A 108
LEU A 163
ASP A 161
 None
 0.69A 5zv2B-4by4A:
undetectable		 5zv2B-4by4A:
16.22