SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4by6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 TRP B  60
TYR A1806
LEU A1785
 None
 1.05A 1kxhA-4by6B:
undetectable		 1kxhA-4by6B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 ILE A1668
LEU A1650
GLY A1644
SER A1645
LEU A1583
 None
 1.35A 1kyvA-4by6A:
undetectable
1kyvB-4by6A:
undetectable		 1kyvA-4by6A:
14.31
1kyvB-4by6A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1738
LEU A1780
MET A1766
 None
 0.67A 1ya3B-4by6A:
undetectable		 1ya3B-4by6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A2065
ILE A2074
ILE A2052
LEU A2059
PHE A2048
 None
 1.10A 1z11C-4by6A:
undetectable		 1z11C-4by6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 10 VAL A2065
ILE A2074
ILE A2052
LEU A2059
PHE A2048
 None
 1.05A 1z11D-4by6A:
undetectable		 1z11D-4by6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 VAL A2046
GLY A2043
THR A1999
ILE A1869
 None
 0.78A 2a1mB-4by6A:
undetectable		 2a1mB-4by6A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A1912
SER A1910
SER A1977
LEU A1972
 None
 0.99A 2cdqA-4by6A:
undetectable		 2cdqA-4by6A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 6 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.90A 2e1qC-4by6B:
undetectable		 2e1qC-4by6B:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ARG C 533
ASP C 473
ASP B 109
 None
 0.73A 2ejtA-4by6C:
undetectable		 2ejtA-4by6C:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1646
ILE A1647
LEU A1612
ILE A1606
TYR A1664
 None
 1.27A 2f78B-4by6A:
undetectable		 2f78B-4by6A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1972
LEU A1969
ILE A1908
PRO A1892
ASN A1895
 None
 1.34A 2ft9A-4by6A:
undetectable		 2ft9A-4by6A:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A1668
PHE A1730
PHE A1734
ILE A1648
 None
 1.15A 2hjhA-4by6A:
undetectable		 2hjhA-4by6A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1816
LEU A1785
PHE A1786
LEU A1789
TYR A1806
 None
 1.26A 2mjiA-4by6A:
undetectable		 2mjiA-4by6A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1600
LEU A1650
LEU A1651
ILE A1699
LEU A1643
 None
 1.04A 2ouzA-4by6A:
undetectable		 2ouzA-4by6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1669
ILE A1672
GLY A1644
ILE A1640
 None
 0.92A 2qwxA-4by6A:
undetectable
2qwxB-4by6A:
undetectable		 2qwxA-4by6A:
14.44
2qwxB-4by6A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 8 HIS B  50
ASP C 457
ARG C 495
ALA C 466
 None
 1.34A 2rk8A-4by6B:
undetectable		 2rk8A-4by6B:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.50A 2zd1A-4by6A:
undetectable		 2zd1A-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 7 TYR A1965
TRP A2001
ILE A1948
HIS A1998
 None
 1.01A 2zm7A-4by6A:
undetectable		 2zm7A-4by6A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.81A 3ax7A-4by6B:
undetectable		 3ax7A-4by6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 9 VAL A1804
VAL A1805
GLY A1808
PRO B  59
THR B  63
 None
 0.93A 3bjwG-4by6A:
undetectable		 3bjwG-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1804
GLY A1808
ILE A1812
PRO B  59
THR B  63
 None
 0.98A 3bjwB-4by6A:
undetectable		 3bjwB-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_1
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 10 VAL A1804
VAL A1805
GLY A1808
PRO B  59
THR B  63
 None
 0.96A 3bjwD-4by6A:
undetectable		 3bjwD-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A1804
VAL A1805
GLY A1808
PRO B  59
 None
 0.90A 3bjwC-4by6A:
undetectable		 3bjwC-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1804
GLY A1808
ILE A1812
PRO B  59
THR B  63
 None
 0.94A 3bjwE-4by6A:
undetectable		 3bjwE-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1804
GLY A1808
ILE A1812
PRO B  59
THR B  63
 None
 0.87A 3bjwF-4by6A:
undetectable		 3bjwF-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 8 VAL A1804
VAL A1805
GLY A1808
PRO B  59
 None
 0.98A 3bjwA-4by6A:
undetectable		 3bjwA-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 11 VAL A1804
GLY A1808
ILE A1812
PRO B  59
THR B  63
 None
 1.01A 3bjwH-4by6A:
undetectable		 3bjwH-4by6A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 4 ILE A1935
GLN A1991
ILE A1973
LEU A1847
 None
 1.31A 3dzyD-4by6A:
undetectable		 3dzyD-4by6A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 ILE B  43
SER B  40
SER B  36
 None
 0.59A 3iltH-4by6B:
undetectable		 3iltH-4by6B:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 TYR B 187
GLY B 161
ASP B 160
 None
 0.61A 3ou6C-4by6B:
undetectable		 3ou6C-4by6B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 HIS A1828
ARG A1993
GLU A1990
 None
 1.11A 3qf1A-4by6A:
undetectable		 3qf1A-4by6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1829
ASP A1931
ASP A1885
 None
CA  A3080 (-3.6A)
None
 0.55A 3r24A-4by6A:
undetectable		 3r24A-4by6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 ASN C 390
PHE A1751
ALA A1752
THR A1755
 None
 1.12A 3t3sB-4by6C:
undetectable		 3t3sB-4by6C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 ARG A2033
PRO A1837
PHE A1840
 None
 1.00A 3thrC-4by6A:
undetectable		 3thrC-4by6A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.80A 3uniA-4by6B:
undetectable		 3uniA-4by6B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1982
PHE A1840
ARG A2028
 None
 1.24A 4g19D-4by6A:
undetectable		 4g19D-4by6A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.47A 4g1qA-4by6A:
undetectable		 4g1qA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A1994
HIS A1828
ARG A1993
 None
 0.91A 4htfA-4by6A:
undetectable		 4htfA-4by6A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ICL_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.49A 4iclA-4by6A:
undetectable		 4iclA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.50A 4id5A-4by6A:
undetectable		 4id5A-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IDK_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.48A 4idkA-4by6A:
undetectable		 4idkA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.47A 4ifvA-4by6A:
undetectable		 4ifvA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.50A 4ifyA-4by6A:
undetectable		 4ifyA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.44A 4ig3A-4by6A:
undetectable		 4ig3A-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		4 / 4 LYS B 134
LEU B 132
GLU B 131
LEU B 112
 None
 1.44A 4k4yE-4by6B:
undetectable		 4k4yE-4by6B:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.48A 4kfbA-4by6A:
undetectable		 4kfbA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 VAL A1601
LEU A1600
LEU A1612
PHE A1726
 None
 1.07A 4o1zA-4by6A:
undetectable		 4o1zA-4by6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 11 GLY A1644
LEU A1620
VAL A1616
TRP A1703
ILE A1699
 None
 1.31A 4pghC-4by6A:
undetectable		 4pghC-4by6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 8 PHE A1669
ILE A1672
GLY A1644
ILE A1640
 None
 0.97A 4qogA-4by6A:
undetectable
4qogB-4by6A:
undetectable		 4qogA-4by6A:
14.44
4qogB-4by6A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1939
ILE A1938
ASN A1975
LEU A1905
LEU A1909
 None
 1.24A 4yvpB-4by6A:
undetectable		 4yvpB-4by6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 492
GLN C 490
PHE C 469
LEU C 465
 None
 0.99A 5b3sP-4by6C:
undetectable		 5b3sP-4by6C:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1741
LEU A1738
SER A1735
THR A1733
 None
 1.06A 5bojA-4by6A:
undetectable		 5bojA-4by6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.47A 5cymA-4by6A:
undetectable		 5cymA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.45A 5cyqA-4by6A:
undetectable		 5cyqA-4by6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		3 / 3 TRP B  60
ILE A1812
SER A1758
 None
 1.03A 5gqbA-4by6B:
undetectable		 5gqbA-4by6B:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 170
TYR B 168
ALA B 145
ILE B 190
LEU B 184
 None
 1.39A 5ljbA-4by6B:
undetectable		 5ljbA-4by6B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae) 		4 / 6 PHE B 116
THR B 128
TYR C 484
PHE C 472
 None
 1.36A 5lrbA-4by6B:
undetectable		 5lrbA-4by6B:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A220_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A1992
VAL A1989
LEU A1940
HIS A1828
THR A2041
 None
 1.47A 5mxbA-4by6A:
undetectable		 5mxbA-4by6A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  51
PRO A1764
TYR C 460
 None
 1.05A 5tzoB-4by6B:
undetectable		 5tzoB-4by6B:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		6 / 12 PHE A2030
ILE A1988
GLN A1983
ILE A1978
ILE A2026
MET A2009
 None
 1.30A 5y2tB-4by6A:
undetectable		 5y2tB-4by6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1802
VAL A1798
TYR A1792
PHE A1788
TYR A1839
 None
 1.46A 6eliA-4by6A:
undetectable		 6eliA-4by6A:
8.50