SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4by9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		4 / 6 VAL E 224
GLY E 174
LEU E 160
GLU E 199
 None
 0.88A 1fduD-4by9E:
7.1		 1fduD-4by9E:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
ALA E  83
SER E  84
THR E  87
ALA E 131
 None
C  X   5 ( 2.4A)
C  X   6 ( 3.3A)
C  X   6 ( 2.6A)
None
 1.05A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 LYS E  57
TYR E  79
GLY E  81
SER E 107
ALA E 131
ASP E 150
 C  X   5 ( 2.7A)
None
None
G  A  22 ( 2.7A)
None
C  X   5 ( 3.2A)
 0.87A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 TYR E  79
GLY E  81
ALA E  83
THR E  87
ALA E 131
 None
None
C  X   5 ( 2.4A)
C  X   6 ( 2.6A)
None
 0.78A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 TYR E  79
GLY E  81
ALA E  83
THR E  87
GLN E 153
 None
None
C  X   5 ( 2.4A)
C  X   6 ( 2.6A)
G  A  24 ( 3.0A)
 1.13A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 TYR E  79
GLY E  81
THR E  87
ALA E 131
ASP E 150
 None
None
C  X   6 ( 2.6A)
None
C  X   5 ( 3.2A)
 0.82A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 TYR E  79
GLY E  81
THR E  87
ASP E 150
GLN E 153
 None
None
C  X   6 ( 2.6A)
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 1.17A 1nt2A-4by9E:
28.2		 1nt2A-4by9E:
44.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 11 LEU C 253
VAL C 257
GLY C 258
VAL C 307
ILE C 308
 None
 1.00A 1phgA-4by9C:
undetectable		 1phgA-4by9C:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU C 253
VAL C 257
GLY C 258
VAL C 307
ILE C 308
 None
 1.13A 2a1oB-4by9C:
undetectable		 2a1oB-4by9C:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		3 / 3 GLY E  81
GLU E 105
ASP E 150
 None
None
C  X   5 ( 3.2A)
 0.59A 2b25B-4by9E:
12.0		 2b25B-4by9E:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 LYS C 107
ARG C   7
VAL C   6
 None
 0.90A 2r2vC-4by9C:
undetectable
2r2vD-4by9C:
undetectable		 2r2vC-4by9C:
6.42
2r2vD-4by9C:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 1.00A 2vxaA-4by9C:
undetectable
2vxaC-4by9C:
undetectable
2vxaE-4by9C:
undetectable		 2vxaA-4by9C:
16.06
2vxaC-4by9C:
16.06
2vxaE-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 0.99A 2vxaA-4by9C:
undetectable
2vxaB-4by9C:
undetectable
2vxaK-4by9C:
undetectable		 2vxaA-4by9C:
16.06
2vxaB-4by9C:
16.06
2vxaK-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 1.01A 2vxaB-4by9C:
undetectable
2vxaC-4by9C:
undetectable
2vxaG-4by9C:
undetectable		 2vxaB-4by9C:
16.06
2vxaC-4by9C:
16.06
2vxaG-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 1.01A 2vxaD-4by9C:
undetectable
2vxaF-4by9C:
undetectable
2vxaI-4by9C:
undetectable		 2vxaD-4by9C:
16.06
2vxaF-4by9C:
16.06
2vxaI-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 1.00A 2vxaD-4by9C:
undetectable
2vxaE-4by9C:
undetectable
2vxaL-4by9C:
undetectable		 2vxaD-4by9C:
16.06
2vxaE-4by9C:
16.06
2vxaL-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 327
HIS C 305
GLN C 284
ARG C 322
 U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
G  B  51 ( 3.3A)
 1.01A 2vxaF-4by9C:
undetectable
2vxaG-4by9C:
undetectable
2vxaI-4by9C:
undetectable		 2vxaF-4by9C:
16.06
2vxaG-4by9C:
16.06
2vxaI-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 327
HIS C 305
GLN C 284
ARG C 322
 U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
G  B  51 ( 3.3A)
 0.99A 2vxaB-4by9C:
undetectable
2vxaG-4by9C:
undetectable
2vxaH-4by9C:
undetectable		 2vxaB-4by9C:
16.06
2vxaG-4by9C:
16.06
2vxaH-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 322
ARG C 327
HIS C 305
GLN C 284
 G  B  51 ( 3.3A)
U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
 1.00A 2vxaH-4by9C:
undetectable
2vxaI-4by9C:
undetectable
2vxaJ-4by9C:
undetectable		 2vxaH-4by9C:
16.06
2vxaI-4by9C:
16.06
2vxaJ-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 327
HIS C 305
GLN C 284
ARG C 322
 U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
G  B  51 ( 3.3A)
 1.00A 2vxaD-4by9C:
undetectable
2vxaJ-4by9C:
undetectable
2vxaL-4by9C:
undetectable		 2vxaD-4by9C:
16.06
2vxaJ-4by9C:
16.06
2vxaL-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 327
HIS C 305
GLN C 284
ARG C 322
 U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
G  B  51 ( 3.3A)
 1.00A 2vxaH-4by9C:
undetectable
2vxaJ-4by9C:
undetectable
2vxaK-4by9C:
undetectable		 2vxaH-4by9C:
16.06
2vxaJ-4by9C:
16.06
2vxaK-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ARG C 327
HIS C 305
GLN C 284
ARG C 322
 U  B  48 ( 2.6A)
G  B  51 ( 4.7A)
C  B  27 ( 2.2A)
G  B  51 ( 3.3A)
 1.01A 2vxaA-4by9C:
undetectable
2vxaK-4by9C:
undetectable
2vxaL-4by9C:
undetectable		 2vxaA-4by9C:
16.06
2vxaK-4by9C:
16.06
2vxaL-4by9C:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 4 ALA C 225
TYR C 153
ALA C 172
TYR C 170
 None
 1.26A 2wlkA-4by9C:
3.6
2wlkB-4by9C:
3.4		 2wlkA-4by9C:
20.41
2wlkB-4by9C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		4 / 6 GLY E  81
ILE E 104
GLU E 105
ASP E 150
 None
None
None
C  X   5 ( 3.2A)
 0.59A 3a7eA-4by9E:
12.9		 3a7eA-4by9E:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 11 LYS E  57
GLY E  81
THR E  87
ASP E 130
ALA E 131
ASP E 150
GLN E 153
 C  X   5 ( 2.7A)
None
C  X   6 ( 2.6A)
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 1.09A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		9 / 11 LYS E  57
TYR E  79
GLY E  81
THR E  87
GLU E 105
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 C  X   5 ( 2.7A)
None
None
C  X   6 ( 2.6A)
None
None
None
None
C  X   5 ( 3.2A)
 0.89A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 11 TYR E  79
PHE E 106
ASP E 130
ALA E 131
ILE E 159
 None
 1.33A 3id5B-4by9E:
30.4		 3id5B-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 11 LYS E  57
GLY E  81
ASP E 130
ALA E 131
ASP E 150
GLN E 153
 C  X   5 ( 2.7A)
None
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 1.08A 3id5F-4by9E:
30.4		 3id5F-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		9 / 11 LYS E  57
TYR E  79
GLY E  81
THR E  87
GLU E 105
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 C  X   5 ( 2.7A)
None
None
C  X   6 ( 2.6A)
None
None
None
None
C  X   5 ( 3.2A)
 0.89A 3id5F-4by9E:
30.4		 3id5F-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 11 TYR E  79
PHE E 106
ASP E 130
ALA E 131
ILE E 159
 None
 1.33A 3id5F-4by9E:
30.4		 3id5F-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 TYR E  79
GLY E  81
ALA E  83
THR E  87
ASP E 130
ALA E 131
GLN E 153
 None
None
C  X   5 ( 2.4A)
C  X   6 ( 2.6A)
None
None
G  A  24 ( 3.0A)
 0.77A 3id6C-4by9E:
31.4		 3id6C-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		9 / 12 TYR E  79
GLY E  81
ALA E  83
THR E  87
GLU E 105
PHE E 106
SER E 107
ASP E 130
ALA E 131
 None
None
C  X   5 ( 2.4A)
C  X   6 ( 2.6A)
None
None
G  A  22 ( 2.7A)
None
None
 0.75A 3id6C-4by9E:
31.4		 3id6C-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 TYR E  79
GLY E  81
THR E  87
ASP E 130
ALA E 131
ASP E 150
GLN E 153
 None
None
C  X   6 ( 2.6A)
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 0.88A 3id6C-4by9E:
31.4		 3id6C-4by9E:
51.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		9 / 12 TYR E  79
GLY E  81
THR E  87
GLU E 105
PHE E 106
SER E 107
ASP E 130
ALA E 131
ASP E 150
 None
None
C  X   6 ( 2.6A)
None
None
G  A  22 ( 2.7A)
None
None
C  X   5 ( 3.2A)
 0.64A 3id6C-4by9E:
31.4		 3id6C-4by9E:
51.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  85
VAL E 144
SER E  92
ARG E  49
ILE E 101
 C  X   6 ( 3.4A)
None
None
None
None
 1.23A 3k13C-4by9E:
undetectable		 3k13C-4by9E:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		4 / 4 GLY E  81
GLU E 105
ASP E 130
ASP E 150
 None
None
None
C  X   5 ( 3.2A)
 0.60A 3mb5A-4by9E:
14.5		 3mb5A-4by9E:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		8 / 12 GLY E  81
ALA E  83
GLU E 105
PHE E 106
SER E 107
ASP E 130
ALA E 131
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
G  A  22 ( 2.7A)
None
None
G  A  24 ( 3.0A)
 0.93A 3nmuA-4by9E:
undetectable
3nmuF-4by9E:
34.7		 3nmuA-4by9E:
22.51
3nmuF-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		9 / 12 LYS E  57
GLY E  81
GLU E 105
PHE E 106
SER E 107
ASP E 130
ALA E 131
ASP E 150
GLN E 153
 C  X   5 ( 2.7A)
None
None
None
G  A  22 ( 2.7A)
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 1.03A 3nmuA-4by9E:
undetectable
3nmuF-4by9E:
34.7		 3nmuA-4by9E:
22.51
3nmuF-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 11 GLY E  81
ALA E  83
ILE E 104
GLU E 105
PHE E 106
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
G  A  24 ( 3.0A)
 0.77A 3nmuB-4by9E:
undetectable
3nmuJ-4by9E:
34.8		 3nmuB-4by9E:
22.51
3nmuJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 11 GLY E  81
ALA E  83
ILE E 104
PHE E 106
ALA E 131
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
G  A  24 ( 3.0A)
 0.83A 3nmuB-4by9E:
undetectable
3nmuJ-4by9E:
34.8		 3nmuB-4by9E:
22.51
3nmuJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 11 GLY E  81
ILE E 104
GLU E 105
PHE E 106
ASP E 150
GLN E 153
 None
None
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 0.81A 3nmuB-4by9E:
undetectable
3nmuJ-4by9E:
34.8		 3nmuB-4by9E:
22.51
3nmuJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 11 GLY E  81
ILE E 104
PHE E 106
ALA E 131
ASP E 150
GLN E 153
 None
None
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 0.92A 3nmuB-4by9E:
undetectable
3nmuJ-4by9E:
34.8		 3nmuB-4by9E:
22.51
3nmuJ-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 GLY E  81
ALA E  83
ILE E 104
ASP E 130
ALA E 131
VAL E 151
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
None
G  A  24 ( 3.0A)
 0.96A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ALA E  83
ILE E 104
PHE E 106
ASP E 130
ALA E 131
 None
C  X   5 ( 2.4A)
None
None
None
None
 0.86A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		8 / 12 GLY E  81
THR E  87
ILE E 104
ASP E 130
ALA E 131
ASP E 150
VAL E 151
GLN E 153
 None
C  X   6 ( 2.6A)
None
None
None
C  X   5 ( 3.2A)
None
G  A  24 ( 3.0A)
 1.11A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 GLY E  81
THR E  87
ILE E 104
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 None
C  X   6 ( 2.6A)
None
None
None
None
C  X   5 ( 3.2A)
 0.99A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		8 / 12 LYS E  57
GLY E  81
ILE E 104
ASP E 130
ALA E 131
ASP E 150
VAL E 151
GLN E 153
 C  X   5 ( 2.7A)
None
None
None
None
C  X   5 ( 3.2A)
None
G  A  24 ( 3.0A)
 1.19A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 LYS E  57
GLY E  81
ILE E 104
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 C  X   5 ( 2.7A)
None
None
None
None
None
C  X   5 ( 3.2A)
 0.97A 3nvkI-4by9E:
34.5		 3nvkI-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ALA E  83
ASP E 130
ALA E 131
VAL E 151
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
G  A  24 ( 3.0A)
 0.93A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
ALA E  83
GLU E 105
ASP E 130
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
G  A  24 ( 3.0A)
 0.86A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
ALA E  83
GLU E 105
PHE E 106
ASP E 130
 None
C  X   5 ( 2.4A)
None
None
None
 0.73A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
ALA E  83
PHE E 106
ASP E 130
ALA E 131
 None
C  X   5 ( 2.4A)
None
None
None
 0.79A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ASP E 130
ALA E 131
ASP E 150
VAL E 151
GLN E 153
 None
None
None
C  X   5 ( 3.2A)
None
G  A  24 ( 3.0A)
 1.13A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
GLU E 105
ASP E 130
ASP E 150
GLN E 153
 None
None
None
C  X   5 ( 3.2A)
G  A  24 ( 3.0A)
 0.99A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
GLU E 105
PHE E 106
ASP E 130
ASP E 150
 None
None
None
None
C  X   5 ( 3.2A)
 0.78A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 12 GLY E  81
PHE E 106
ASP E 130
ALA E 131
ASP E 150
 None
None
None
None
C  X   5 ( 3.2A)
 0.81A 3nvkF-4by9E:
undetectable
3nvkJ-4by9E:
34.5		 3nvkF-4by9E:
22.96
3nvkJ-4by9E:
97.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 10 ILE E 127
ALA E 131
LEU E  78
LEU E  80
VAL E 151
 None
 1.23A 3o02A-4by9E:
undetectable
3o02B-4by9E:
undetectable		 3o02A-4by9E:
18.04
3o02B-4by9E:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 9 TYR E 102
ILE E 125
ILE E 124
TYR E  79
ILE E  82
 None
 1.43A 3p4wA-4by9E:
undetectable		 3p4wA-4by9E:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_1
(N-METHYLTRANSFERASE)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TYR C  23
TYR C  10
GLU C 104
 None
 0.94A 3pfgA-4by9C:
undetectable		 3pfgA-4by9C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		5 / 9 LEU C  51
LEU C  47
ILE C  40
GLU C  45
PHE C  59
 None
 1.42A 3tmzA-4by9C:
undetectable		 3tmzA-4by9C:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ALA E  83
ASP E 130
ALA E 131
VAL E 151
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
G  A  24 ( 3.0A)
 0.79A 4df3A-4by9E:
29.5		 4df3A-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
THR E  86
VAL E 110
ALA E 131
VAL E 151
GLN E 153
 None
A  X   7 ( 3.5A)
G  A  21 ( 4.3A)
None
None
G  A  24 ( 3.0A)
 0.70A 4df3A-4by9E:
29.5		 4df3A-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 LYS E  57
GLY E  81
ASP E 130
ALA E 131
ASP E 150
VAL E 151
GLN E 153
 C  X   5 ( 2.7A)
None
None
None
C  X   5 ( 3.2A)
None
G  A  24 ( 3.0A)
 1.11A 4df3A-4by9E:
29.5		 4df3A-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 LYS E  57
GLY E  81
VAL E 110
ALA E 131
VAL E 151
GLN E 153
 C  X   5 ( 2.7A)
None
G  A  21 ( 4.3A)
None
None
G  A  24 ( 3.0A)
 0.90A 4df3A-4by9E:
29.5		 4df3A-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ALA E  83
ASP E 130
ALA E 131
VAL E 151
GLN E 153
 None
C  X   5 ( 2.4A)
None
None
None
G  A  24 ( 3.0A)
 0.78A 4df3B-4by9E:
29.6		 4df3B-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
ALA E  83
VAL E 110
ALA E 131
VAL E 151
GLN E 153
 None
C  X   5 ( 2.4A)
G  A  21 ( 4.3A)
None
None
G  A  24 ( 3.0A)
 0.75A 4df3B-4by9E:
29.6		 4df3B-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 GLY E  81
THR E  86
VAL E 110
ALA E 131
VAL E 151
GLN E 153
 None
A  X   7 ( 3.5A)
G  A  21 ( 4.3A)
None
None
G  A  24 ( 3.0A)
 0.70A 4df3B-4by9E:
29.6		 4df3B-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		7 / 12 LYS E  57
GLY E  81
ASP E 130
ALA E 131
ASP E 150
VAL E 151
GLN E 153
 C  X   5 ( 2.7A)
None
None
None
C  X   5 ( 3.2A)
None
G  A  24 ( 3.0A)
 1.08A 4df3B-4by9E:
29.6		 4df3B-4by9E:
54.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		6 / 12 LYS E  57
GLY E  81
VAL E 110
ALA E 131
VAL E 151
GLN E 153
 C  X   5 ( 2.7A)
None
G  A  21 ( 4.3A)
None
None
G  A  24 ( 3.0A)
 0.87A 4df3B-4by9E:
29.6		 4df3B-4by9E:
54.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 PHE C  59
PHE C  61
ALA C  11
LEU C  44
 None
 1.03A 4ejgA-4by9C:
undetectable		 4ejgA-4by9C:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		4 / 7 VAL E  35
SER E  92
GLN E  33
LEU E 114
 None
 1.13A 4hxyB-4by9E:
5.4		 4hxyB-4by9E:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 4by9 NOP5/NOP56 RELATED
PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ALA C 204
ILE C 183
LEU C 160
PHE C 157
 None
 1.06A 4uymB-4by9C:
undetectable		 4uymB-4by9C:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 4by9 NOP5/NOP56 RELATED
PROTEIN
FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		3 / 3 SER E  92
GLU E  47
GLU C 226
 None
 0.80A 4ymgB-4by9E:
11.9		 4ymgB-4by9E:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 10 TYR E 102
ILE E 125
ILE E 124
TYR E  79
ILE E  82
 None
 1.39A 5mzrA-4by9E:
undetectable		 5mzrA-4by9E:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 9 TYR E 102
ILE E 125
ILE E 124
TYR E  79
ILE E  82
 None
 1.38A 5mzrD-4by9E:
undetectable		 5mzrD-4by9E:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 4by9 FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
(Pyrococcus
furiosus) 		5 / 11 GLY E  81
GLU E 105
SER E 107
ASP E 130
ALA E 131
 None
None
G  A  22 ( 2.7A)
None
None
 0.78A 5x6yC-4by9E:
6.3		 5x6yC-4by9E:
15.21